Results 21 to 30 of about 12,985 (151)
Nuclear AXIN2 represses MYC gene expression [PDF]
Biochemical and Biophysical Research Communications, 2014 The β-catenin transcriptional coactivator is the key mediator of the canonical Wnt signaling pathway. In the absence of Wnt, β-catenin associates with a cytosolic and multi-protein destruction complex where it is phosphorylated and targeted for proteasomal degradation.
Sherri A, Rennoll +2 more
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BMC Medical Genetics, 2020 Background Pathogenic AXIN2 variants cause absence of permanent teeth (hypodontia), sparse hair and eye brows (ectodermal dysplasia), and gastrointestinal polyps and cancer. Inheritance is autosomal dominant with variable penetrance.
Sarah K. Macklin- Mantia +7 more
doaj +1 more source
Biomolecules, 2023 The scaffolding protein Axin is an important regulator of the Wnt signaling pathway, and its dysfunction is closely related to carcinogenesis. Axin could affect the assembly and dissociation of the β-catenin destruction complex.
Lianqi Chen +7 more
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Molecular and Genetic Basis of Non-Syndromic Tooth Agenesis
Česká Stomatologie a Praktické Zubní Lékařství, 2015 Background: Tooth agenesis represents the most common anomaly of dental development, which according to Online Mendelian Inheritance in Man (OMIM) database, affects approximately 20% of the population.
L. Kramerová +3 more
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on AXIN2 (axin 2), with data on DNA, on the protein encoded, and where the gene is implicated.
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BMC Cancer, 2020 Background In bone-invasive oral squamous cell carcinoma (OSCC), cancer-associated fibroblasts (CAFs) infiltrate into bony tissue ahead of OSCC cells.
Yin-Zhe An +3 more
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BMC Genomics, 2021 Objective Colon cancer (CC) is one of the most common cancers whose progression is regulated by a number of factors, including circular RNAs (circRNAs).
Haitao Gu +5 more
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Expression of β-catenin and AXIN2 in ameloblastomas
Współczesna Onkologia, 2013 To investigate the expression status and association of β-catenin and AXIN2 in ameloblastoma.30 ameloblastoma specimens and 10 normal oral mucosa tissues were enrolled in the study. The protein and RNA levels of β-catenin and AXIN2 were detected by immunohistochemistry staining, Western blot, and real-time PCR analysis.
Wei, Zhenhui +5 more
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Axin2+ endometrial stem cells: the source of endometrial regeneration and cancer
Molecular & Cellular Oncology, 2020 Menstruation is one of the basic but poorly understood life processes in primates during which females shed inner uterine lining every month only to be completely regenerated back within a week.
Shafiq M. Syed, Pradeep S. Tanwar
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Conductin/axin2 and Wnt signalling regulates centrosome cohesion [PDF]
The EMBO Reports, 2010 Activated Wnt/beta-catenin signalling is a characteristic of many cancers and drives cell-cycle progression. Here, we report a mechanism linking Wnt/beta-catenin signalling to centrosome separation. We show that conductin/axin2, a negative regulator of beta-catenin, localizes at the centrosomes by binding to the centriole-associated component C-Nap1 ...
Michel V, Hadjihannas +2 more
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