Results 1 to 10 of about 12,985 (151)

Two novel AXIN2 variants in isolated tooth agenesis and the AXIN2-associated tooth agenesis pattern [PDF]

BMC Oral Health
Background Variants in the AXIN2 gene are associated with colorectal cancer, oligodontia-colorectal cancer syndrome, and isolated tooth agenesis. To date, only 19 AXIN2 variants have been linked to tooth agenesis. This study aimed to identify novel AXIN2
Chenxin Geng, Bichen Lin, Yang Liu, Kai Sun, Miao Yu, Haochen Liu, Hailan Feng, Dong Han   +7 more
doaj   +4 more sources

Elevated expression of Axin2 in intestinal metaplasia and gastric cancers [PDF]

Journal of Pathology and Translational Medicine, 2023
Background The Wnt signaling pathway regulates crucial cellular processes, including stem cell development and tissue repair. Dysregulation of this pathway, particularly β-catenin stabilization, is linked to colorectal carcinoma and other tumors.
Dong Hui Lee, In Ho Jeong, Bogun Jang
doaj   +3 more sources

Detection of a rare AXIN2 variant in an Iranian family with hypodontia and oligodontia [PDF]

Journal of Dental Research, Dental Clinics, Dental Prospects, 2022
Background. Hypodontia, or the absence of one or more teeth during tooth formation, is a highly prevalent dental anomaly. Nevertheless, the main causes are still unknown.
Shiva Safari, Asghar Ebadifar, Hossien Najmabadi, Koorosh Kamali, Seyedeh Sedigheh Abedini, Mohammad Mousavi   +5 more
doaj   +3 more sources

Tooth agenesis as a potential clinical indicator of colorectal cancer susceptibility: a systematic review [PDF]

Frontiers in Oral Health
BackgroundTooth agenesis, including hypodontia and oligodontia, is one of the most common developmental dental anomalies. Emerging evidence suggests a potential association between tooth agenesis and colorectal cancer (CRC), particularly in the context ...
Ahmad Shoeb Hashmi, Ahmad Shoeb Hashmi, Raji Ranganathan, Kunal Vats, Diana Baburaj, Pedro Sampaio, Dhvani Chauhan, Onaiza Kulsum, Rahul Tiwari   +8 more
doaj   +2 more sources

AXIN2-related oligodontia-colorectal cancer syndrome with cleft palate as a possible new feature

Molecular Genetics & Genomic Medicine, 2023
Background Pathogenic variants in AXIN2 have been associated with tooth agenesis, colon polyps, and colon cancer. Given the rare nature of this phenotype, we set out to collect additional genotypic and phenotypic information.
Rolf H Sijmons, Pilvi Ilves, Katrin Õunap   +2 more
exaly   +2 more sources

AXIN2 variants, tooth agenesis, and cancer risk: a systematic review [PDF]

BMC Oral Health
Background Variants in the Axis Inhibition Protein 2 (AXIN2) have been associated with tooth agenesis, a congenital condition characterized by missing teeth, and an increased risk of various cancers.
Nutthakarn Ratanasereeprasert, Narin Intarak, Chayanit Chaweewannakorn, Mushriq Abid, Anand Marya, Sung-dae Cho, Thantrira Porntaveetus   +6 more
doaj   +2 more sources

Long non-coding RNA AFAP1-AS1 promotes alternative splicing of AXIN2 by facilitating SRSFs phase separation to induce drug resistance in lung adenocarcinoma [PDF]

Molecular Cancer
Lung cancer currently holds the highest global incidence and mortality rates among malignant tumors, with lung adenocarcinoma being the most prevalent and deadly subtype.
Jiawei Ouyang, Yijie Zhang, Xiangchan Hou, Fang Xiong, Lei Shi, Yu Zhong, Liting Yang, Can Guo, Zhaoyang Zeng, Qijia Yan, Pan Chen, Wei Xiong   +11 more
doaj   +2 more sources

Wnt/β -catenin signalling shapes macrophage behaviour during injury and repair in the mouse submandibular gland [PDF]

Scientific Reports
Xerostomia, the subjective sensation of dry mouth, is a debilitating consequence of head and neck radiotherapy and autoimmune disorders such as Sjögren’s syndrome.
Araz Ahmed, Suveer Sachdeva, Simon Whawell, Isabelle Miletich   +3 more
doaj   +2 more sources

The role of Axin2+ cells in periodontal tissue development and regeneration

口腔疾病防治, 2022
As a highly conserved signal pathway in evolution, the WNT signaling pathway plays an essential role in periodontium growth, development and injury repair.
SHI Binmian, XIE Xudong, WANG Jun
doaj   +1 more source

Correlation of rare mutation in AXIN2 with human neural tube defects

陆军军医大学学报, 2023
Objective To investigate the correlation between genetic variations in the AXIN2 gene and the development of neural tube defects (NTDs). Methods Bioinformatics analysis was performed on AXIN2 gene variations identified through whole-genome sequencing of ...
XU Xuebing, LI Jianting, BAO Yihua
doaj   +1 more source