Axon diameter index estimation independent of fiber orientation distribution using high-gradient diffusion MRI [PDF]
NeuroImage, 2020 Axon diameter mapping using high-gradient diffusion MRI has generated great interest as a noninvasive tool for studying trends in axonal size in the human brain.
Qiuyun Fan +9 more
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Bundle-Specific Axon Diameter Index as a New Contrast to Differentiate White Matter Tracts [PDF]
Frontiers in Neuroscience, 2021 In the central nervous system of primates, several pathways are characterized by different spectra of axon diameters. In vivo methods, based on diffusion-weighted magnetic resonance imaging, can provide axon diameter index estimates non-invasively ...
Muhamed Barakovic +22 more
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The impact of realistic axonal shape on axon diameter estimation using diffusion MRI [PDF]
NeuroImage, 2020 To study axonal microstructure with diffusion MRI, axons are typically modeled as straight impermeable cylinders, whereby the transverse diffusion MRI signal can be made sensitive to the cylinder’s inner diameter. However, the shape of a real axon varies
Hong-Hsi Lee +3 more
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The Regulation of Axon Diameter: From Axonal Circumferential Contractility to Activity-Dependent Axon Swelling [PDF]
Frontiers in Molecular Neuroscience, 2018 In the adult nervous system axon caliber varies widely amongst different tracts. When considering a given axon, its diameter can further fluctuate in space and time, according to processes including the distribution of organelles and activity-dependent ...
Ana Rita Costa +4 more
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Corpus callosum axon diameter relates to cognitive impairment in multiple sclerosis [PDF]
Annals of Clinical and Translational Neurology, 2019 Objective To evaluate alterations in apparent axon diameter and axon density obtained by high‐gradient diffusion MRI in the corpus callosum of MS patients and the relationship of these advanced diffusion MRI metrics to neurologic disability and cognitive
Susie Y. Huang +14 more
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Importin 13-dependent axon diameter growth regulates conduction speeds along myelinated CNS axons [PDF]
Nature CommunicationsAxon diameter influences the conduction properties of myelinated axons, both directly, and indirectly through effects on myelin. However, we have limited understanding of mechanisms controlling axon diameter growth in the central nervous system ...
Jenea M. Bin +9 more
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Deficit of corpus callosum axons, reduced axon diameter and decreased area are markers of abnormal development of interhemispheric connections in autistic subjects [PDF]
Acta Neuropathologica Communications, 2018 Introduction In autism spectrum disorder, lack of coherence and of complex information processing, and narrowly focused interests and repetitive behaviors are considered a sign of long-range underconnectivity and short-range overconnectivity. The goal of
Jarek Wegiel +7 more
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Myelin sheath lengths in the central nervous system scale to axon diameter via oligodendroglial Piezo1. [PDF]
PLoS BiologyMyelin sheath lengths vary by an order of magnitude in the central nervous system (CNS) and tune the timing of neuronal signaling. Thus, variation in myelin sheath length has been proposed to coordinate the timing of neuronal signaling to ultimately ...
Amanda R Young +8 more
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The Actin-Binding Protein α-Adducin Is Required for Maintaining Axon Diameter [PDF]
Cell Reports, 2016 The actin-binding protein adducin was recently identified as a component of the neuronal subcortical cytoskeleton. Here, we analyzed mice lacking adducin to uncover the function of this protein in actin rings.
Sérgio Carvalho Leite +7 more
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Towards higher sensitivity and stability of axon diameter estimation with diffusion-weighted MRI [PDF]
NMR in Biomedicine, 2016 Nyoman Kurniawan +2 more
exaly +2 more sources