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Axon Guidance Molecules and Pain [PDF]
Cells, 2022 Chronic pain is a debilitating condition that influences the social, economic, and psychological aspects of patients’ lives. Hence, the need for better treatment is drawing extensive interest from the research community.
Elisa Damo, Manuela Simonetti
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Exosomes: new targets for understanding axon guidance in the developing central nervous system [PDF]
Frontiers in Cell and Developmental BiologyAxon guidance is a key event in neural circuit development that drives the correct targeting of axons to their targets through long distances and unique patterns.
Mingyu Liu +4 more
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The role of axon guidance molecules in the pathogenesis of epilepsy [PDF]
Neural Regeneration ResearchCurrent treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms
Zheng Liu, Chunhua Pan, Hao Huang
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Axon guidance molecules in immunometabolic diseases [PDF]
Inflammation and Regeneration, 2022 The global prevalence of metabolic diseases, such as obesity, diabetes, and atherosclerosis, is rapidly increasing and has now reached epidemic proportions.
Yoshimitsu Nakanishi +2 more
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Optogenetic axon guidance in embryonic zebrafish [PDF]
STAR Protocols, 2021 Summary: Axons form the long-range connections of biological neuronal networks, which are built through the developmental process of axon guidance. Here, we describe a protocol to precisely and non-invasively control axonal growth trajectories in live ...
James M. Harris +2 more
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Frontiers in Neuroanatomy, 2021 Axon guidance proteins play key roles in the formation of neural circuits during development. We previously identified an axon guidance cue, named draxin, that has no homology with other axon guidance proteins.
Giasuddin Ahmed, Yohei Shinmyo
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Endoglycan plays a role in axon guidance by modulating cell adhesion
eLife, 2021 Axon navigation depends on the interactions between guidance molecules along the trajectory and specific receptors on the growth cone. However, our in vitro and in vivo studies on the role of Endoglycan demonstrate that in addition to specific guidance ...
Thomas Baeriswyl +11 more
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A network of HSPG core proteins and HS modifying enzymes regulates netrin-dependent guidance of D-type motor neurons in Caenorhabditis elegans. [PDF]
PLoS ONE, 2013 Heparan sulfate proteoglycans (HSPGs) are proteins with long covalently attached sugar side chains of the heparan sulfate (HS) type. Depending on the cellular context HS chains carry multiple structural modifications such as sulfate residues or ...
Stephan Gysi +4 more
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Cbln1 regulates axon growth and guidance in multiple neural regions.
PLoS Biology, 2022 The accurate construction of neural circuits requires the precise control of axon growth and guidance, which is regulated by multiple growth and guidance cues during early nervous system development.
Peng Han +9 more
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SYD-1C, UNC-40 (DCC) and SAX-3 (Robo) function interdependently to promote axon guidance by regulating the MIG-2 GTPase. [PDF]
PLoS Genetics, 2015 During development, axons must integrate directional information encoded by multiple guidance cues and their receptors. Axon guidance receptors, such as UNC-40 (DCC) and SAX-3 (Robo), can function individually or combinatorially with other guidance ...
Yan Xu +3 more
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