Where does axon guidance lead us? [version 1; referees: 2 approved] [PDF]
F1000Research, 2017 During neural circuit formation, axons need to navigate to their target cells in a complex, constantly changing environment. Although we most likely have identified most axon guidance cues and their receptors, we still cannot explain the molecular ...
Esther Stoeckli
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Axon Guidance Molecules and Pain [PDF]
Cells, 2022 Chronic pain is a debilitating condition that influences the social, economic, and psychological aspects of patients’ lives. Hence, the need for better treatment is drawing extensive interest from the research community.
Elisa Damo, Manuela Simonetti
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Exosomes: new targets for understanding axon guidance in the developing central nervous system [PDF]
Frontiers in Cell and Developmental BiologyAxon guidance is a key event in neural circuit development that drives the correct targeting of axons to their targets through long distances and unique patterns.
Mingyu Liu +4 more
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The role of axon guidance molecules in the pathogenesis of epilepsy [PDF]
Neural Regeneration ResearchCurrent treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms
Zheng Liu, Chunhua Pan, Hao Huang
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The first quarter of the C-terminal domain of Abelson regulates the WAVE regulatory complex and Enabled in axon guidance [PDF]
Neural Development, 2020 Background Abelson tyrosine kinase (Abl) plays a key role in axon guidance in linking guidance receptors to actin dynamics. The long C-terminal domain (CTD) of Drosophila Abl is important for this role, and previous work identified the ‘first quarter ...
Han Sian Joshua Cheong +3 more
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TAG-1 Multifunctionality Coordinates Neuronal Migration, Axon Guidance, and Fasciculation [PDF]
Cell Reports, 2020 Summary: Neuronal migration, axon fasciculation, and axon guidance need to be closely coordinated for neural circuit assembly. Spinal motor neurons (MNs) face unique challenges during development because their cell bodies reside within the central ...
Tracey A.C.S. Suter +5 more
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Transcriptional Control of Axon Guidance at Midline Structures [PDF]
Frontiers in Cell and Developmental Biology, 2022 The development of the nervous system is a time-ordered and multi-stepped process that includes neurogenesis and neuronal specification, axonal navigation, and circuits assembly.
Eloísa Herrera, Augusto Escalante
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Commissural axon guidance in the developing spinal cord: from Cajal to the present day [PDF]
Neural Development, 2019 During neuronal development, the formation of neural circuits requires developing axons to traverse a diverse cellular and molecular environment to establish synaptic contacts with the appropriate postsynaptic partners.
J. D. Comer +3 more
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A tug of war between DCC and ROBO1 signaling during commissural axon guidance. [PDF]
Cell Rep, 2023 Dailey-Krempel B +4 more
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Frontiers in Neuroanatomy, 2021 Axon guidance proteins play key roles in the formation of neural circuits during development. We previously identified an axon guidance cue, named draxin, that has no homology with other axon guidance proteins.
Giasuddin Ahmed, Yohei Shinmyo
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