Results 11 to 20 of about 899,641 (334)
Optogenetic axon guidance in embryonic zebrafish [PDF]
STAR Protocols, 2021 Summary: Axons form the long-range connections of biological neuronal networks, which are built through the developmental process of axon guidance. Here, we describe a protocol to precisely and non-invasively control axonal growth trajectories in live ...
James M. Harris +2 more
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Commissural axon guidance in the developing spinal cord: from Cajal to the present day
Neural Development, 2019 During neuronal development, the formation of neural circuits requires developing axons to traverse a diverse cellular and molecular environment to establish synaptic contacts with the appropriate postsynaptic partners.
J. D. Comer +3 more
doaj +2 more sources
Transcriptional Control of Axon Guidance at Midline Structures [PDF]
Frontiers in Cell and Developmental Biology, 2022 The development of the nervous system is a time-ordered and multi-stepped process that includes neurogenesis and neuronal specification, axonal navigation, and circuits assembly.
Eloísa Herrera, Augusto Escalante
doaj +2 more sources
Glycosylation in Axonal Guidance [PDF]
International Journal of Molecular Sciences, 2021 How millions of axons navigate accurately toward synaptic targets during development is a long-standing question. Over decades, multiple studies have enriched our understanding of axonal pathfinding with discoveries of guidance molecules and morphogens, their receptors, and downstream signalling mechanisms.
Sampada P. Mutalik, Stephanie L. Gupton
openaire +3 more sources
Theory for Durotactic Axon Guidance [PDF]
Physical Review Letters, 2021 During the development of the nervous system, neurons extend bundles of axons that grow and meet other neurons to form the neuronal network. Robust guidance mechanisms are needed for these bundles to migrate and reach their functional target. Directional information depends on external cues such as chemical or mechanical gradients.
Hadrien Oliveri +3 more
openaire +4 more sources
Frontiers in Neuroanatomy, 2021 Axon guidance proteins play key roles in the formation of neural circuits during development. We previously identified an axon guidance cue, named draxin, that has no homology with other axon guidance proteins.
Giasuddin Ahmed, Yohei Shinmyo
doaj +1 more source
COVID‐19 and the risk of Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1953-1961, December 2022., 2022 Abstract Background The coronavirus disease 2019 (COVID‐19) pandemic has had an unprecedented impact on the healthcare system, economy, and society. Studies have reported that COVID‐19 may cause various neurologic symptoms, including cognitive impairment.
Hanyu Zhang, Zengyuan Zhou
wiley +1 more source
Endoglycan plays a role in axon guidance by modulating cell adhesion
eLife, 2021 Axon navigation depends on the interactions between guidance molecules along the trajectory and specific receptors on the growth cone. However, our in vitro and in vivo studies on the role of Endoglycan demonstrate that in addition to specific guidance ...
Thomas Baeriswyl +11 more
doaj +1 more source
A network of HSPG core proteins and HS modifying enzymes regulates netrin-dependent guidance of D-type motor neurons in Caenorhabditis elegans. [PDF]
PLoS ONE, 2013 Heparan sulfate proteoglycans (HSPGs) are proteins with long covalently attached sugar side chains of the heparan sulfate (HS) type. Depending on the cellular context HS chains carry multiple structural modifications such as sulfate residues or ...
Stephan Gysi +4 more
doaj +1 more source
Beyond Axon Guidance: Roles of Slit-Robo Signaling in Neocortical Formation
Frontiers in Cell and Developmental Biology, 2020 The formation of the neocortex relies on intracellular and extracellular signaling molecules that are involved in the sequential steps of corticogenesis, ranging from the proliferation and differentiation of neural progenitor cells to the migration and ...
Yuko Gonda, T. Namba, Carina Hanashima
semanticscholar +1 more source