Results 11 to 20 of about 102,974 (302)
Cbln1 regulates axon growth and guidance in multiple neural regions.
PLoS Biology, 2022 The accurate construction of neural circuits requires the precise control of axon growth and guidance, which is regulated by multiple growth and guidance cues during early nervous system development.
Peng Han +9 more
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Theory for Durotactic Axon Guidance [PDF]
Physical Review Letters, 2021 During the development of the nervous system, neurons extend bundles of axons that grow and meet other neurons to form the neuronal network. Robust guidance mechanisms are needed for these bundles to migrate and reach their functional target. Directional information depends on external cues such as chemical or mechanical gradients.
Oliveri, Hadrien +2 more
openaire +3 more sources
The midline protein regulates axon guidance by blocking the reiteration of neuroblast rows within the Drosophila ventral nerve cord. [PDF]
PLoS Genetics, 2013 Guiding axon growth cones towards their targets is a fundamental process that occurs in a developing nervous system. Several major signaling systems are involved in axon-guidance, and disruption of these systems causes axon-guidance defects. However, the
Mary Ann Manavalan +2 more
doaj +1 more source
PLoS ONE, 2013 Heparan sulfate proteoglycans (HSPGs) are proteins with long covalently attached sugar side chains of the heparan sulfate (HS) type. Depending on the cellular context HS chains carry multiple structural modifications such as sulfate residues or ...
Stephan Gysi +4 more
doaj +1 more source
Modeling of interstitial branching of axonal networks [PDF]
, 2013 A single axon can generate branches connecting with plenty synaptic targets. Process of branching is very important for making connections in central nervous system.
Gafarov, F. +2 more
core +2 more sources
G3: Genes, Genomes, Genetics, 2018 During development, neuronal cells extend an axon toward their target destination in response to a cue to form a properly functioning nervous system.
Jamie K. Alan +4 more
doaj +1 more source
Drosophila semaphorin2b is Required for the Axon Guidance of a Subset of Embryonic Neurons [PDF]
, 2014 Background: The process of axon guidance is important in establishing functional neural circuits. The differential expression of cell-autonomous axon guidance factors is crucial for allowing axons of different neurons to take unique trajectories in ...
Emerson, Mark M +2 more
core +1 more source
Neural Development, 2008 Background How axon guidance signals regulate growth cone behavior and guidance decisions in the complex in vivo environment of the central nervous system is not well understood.
Yost H Joseph +5 more
doaj +1 more source
The Rac GTP exchange factor TIAM-1 acts with CDC-42 and the guidance receptor UNC-40/DCC in neuronal protrusion and axon guidance. [PDF]
PLoS Genetics, 2012 The mechanisms linking guidance receptors to cytoskeletal dynamics in the growth cone during axon extension remain mysterious. The Rho-family GTPases Rac and CDC-42 are key regulators of growth cone lamellipodia and filopodia formation, yet little is ...
Rafael S Demarco +2 more
doaj +1 more source
Cas Adaptor Proteins Coordinate Sensory Axon Fasciculation. [PDF]
, 2018 Development of complex neural circuits like the peripheral somatosensory system requires intricate mechanisms to ensure axons make proper connections. While much is known about ligand-receptor pairs required for dorsal root ganglion (DRG) axon guidance ...
Estep, Jason A +5 more
core +2 more sources