Results 11 to 20 of about 104,244 (349)
microRNAs in axon guidance [PDF]
Frontiers in Cellular Neuroscience, 2014 Brain wiring is a highly intricate process in which trillions of neuronal connections are established. Its initial phase is particularly crucial in establishing the general framework of neuronal circuits.
Archana N Iyer +2 more
doaj +3 more sources
Glycosylation in Axonal Guidance [PDF]
International Journal of Molecular Sciences, 2021 How millions of axons navigate accurately toward synaptic targets during development is a long-standing question. Over decades, multiple studies have enriched our understanding of axonal pathfinding with discoveries of guidance molecules and morphogens, their receptors, and downstream signalling mechanisms.
Sampada P. Mutalik, Stephanie L. Gupton
openaire +2 more sources
Theory for Durotactic Axon Guidance [PDF]
Physical Review Letters, 2021 During the development of the nervous system, neurons extend bundles of axons that grow and meet other neurons to form the neuronal network. Robust guidance mechanisms are needed for these bundles to migrate and reach their functional target. Directional information depends on external cues such as chemical or mechanical gradients.
Oliveri, Hadrien +2 more
openaire +3 more sources
Endoglycan plays a role in axon guidance by modulating cell adhesion
eLife, 2021 Axon navigation depends on the interactions between guidance molecules along the trajectory and specific receptors on the growth cone. However, our in vitro and in vivo studies on the role of Endoglycan demonstrate that in addition to specific guidance ...
Thomas Baeriswyl +11 more
doaj +1 more source
A network of HSPG core proteins and HS modifying enzymes regulates netrin-dependent guidance of D-type motor neurons in Caenorhabditis elegans. [PDF]
PLoS ONE, 2013 Heparan sulfate proteoglycans (HSPGs) are proteins with long covalently attached sugar side chains of the heparan sulfate (HS) type. Depending on the cellular context HS chains carry multiple structural modifications such as sulfate residues or ...
Stephan Gysi +4 more
doaj +1 more source
Cbln1 regulates axon growth and guidance in multiple neural regions.
PLoS Biology, 2022 The accurate construction of neural circuits requires the precise control of axon growth and guidance, which is regulated by multiple growth and guidance cues during early nervous system development.
Peng Han +9 more
doaj +1 more source
SYD-1C, UNC-40 (DCC) and SAX-3 (Robo) function interdependently to promote axon guidance by regulating the MIG-2 GTPase. [PDF]
PLoS Genetics, 2015 During development, axons must integrate directional information encoded by multiple guidance cues and their receptors. Axon guidance receptors, such as UNC-40 (DCC) and SAX-3 (Robo), can function individually or combinatorially with other guidance ...
Yan Xu +3 more
doaj +1 more source
The midline protein regulates axon guidance by blocking the reiteration of neuroblast rows within the Drosophila ventral nerve cord. [PDF]
PLoS Genetics, 2013 Guiding axon growth cones towards their targets is a fundamental process that occurs in a developing nervous system. Several major signaling systems are involved in axon-guidance, and disruption of these systems causes axon-guidance defects. However, the
Mary Ann Manavalan +2 more
doaj +1 more source
BMC Neuroscience, 2007 Background During the development of the Drosophila central nervous system the process of midline crossing is orchestrated by a number of guidance receptors and ligands.
Tomancak Pavel +3 more
doaj +1 more source
Modeling of interstitial branching of axonal networks [PDF]
, 2013 A single axon can generate branches connecting with plenty synaptic targets. Process of branching is very important for making connections in central nervous system.
Gafarov, F. +2 more
core +2 more sources