Results 11 to 20 of about 966,766 (378)
Axon guidance molecules in immunometabolic diseases [PDF]
Inflammation and Regeneration, 2022 The global prevalence of metabolic diseases, such as obesity, diabetes, and atherosclerosis, is rapidly increasing and has now reached epidemic proportions.
Yoshimitsu Nakanishi +2 more
doaj +2 more sources
Motor axon guidance in Drosophila.
Seminars in Cell & Developmental Biology, 2017 The Drosophila motor system starts to assemble during embryonic development. It is composed of 30 muscles per abdominal hemisegment and 36 motor neurons assembling into nerve branches to exit the CNS, navigate within the muscle field and finally establish specific connections with their target muscles. Several families of guidance molecules that play a
Aref Arzan Zarin, J. Labrador
semanticscholar +6 more sources
Optogenetic axon guidance in embryonic zebrafish [PDF]
STAR Protocols, 2021 Summary: Axons form the long-range connections of biological neuronal networks, which are built through the developmental process of axon guidance. Here, we describe a protocol to precisely and non-invasively control axonal growth trajectories in live ...
James M. Harris +2 more
doaj +2 more sources
Glycosylation in Axonal Guidance [PDF]
International Journal of Molecular Sciences, 2021 How millions of axons navigate accurately toward synaptic targets during development is a long-standing question. Over decades, multiple studies have enriched our understanding of axonal pathfinding with discoveries of guidance molecules and morphogens, their receptors, and downstream signalling mechanisms.
Sampada P. Mutalik, Stephanie L. Gupton
openaire +3 more sources
Theory for Durotactic Axon Guidance [PDF]
Physical Review Letters, 2021 During the development of the nervous system, neurons extend bundles of axons that grow and meet other neurons to form the neuronal network. Robust guidance mechanisms are needed for these bundles to migrate and reach their functional target. Directional information depends on external cues such as chemical or mechanical gradients.
Hadrien Oliveri +3 more
openaire +4 more sources
Frontiers in Neuroanatomy, 2021 Axon guidance proteins play key roles in the formation of neural circuits during development. We previously identified an axon guidance cue, named draxin, that has no homology with other axon guidance proteins.
Giasuddin Ahmed, Yohei Shinmyo
doaj +1 more source
Endoglycan plays a role in axon guidance by modulating cell adhesion
eLife, 2021 Axon navigation depends on the interactions between guidance molecules along the trajectory and specific receptors on the growth cone. However, our in vitro and in vivo studies on the role of Endoglycan demonstrate that in addition to specific guidance ...
Thomas Baeriswyl +11 more
doaj +1 more source
A network of HSPG core proteins and HS modifying enzymes regulates netrin-dependent guidance of D-type motor neurons in Caenorhabditis elegans. [PDF]
PLoS ONE, 2013 Heparan sulfate proteoglycans (HSPGs) are proteins with long covalently attached sugar side chains of the heparan sulfate (HS) type. Depending on the cellular context HS chains carry multiple structural modifications such as sulfate residues or ...
Stephan Gysi +4 more
doaj +1 more source
Beyond Axon Guidance: Roles of Slit-Robo Signaling in Neocortical Formation
Frontiers in Cell and Developmental Biology, 2020 The formation of the neocortex relies on intracellular and extracellular signaling molecules that are involved in the sequential steps of corticogenesis, ranging from the proliferation and differentiation of neural progenitor cells to the migration and ...
Yuko Gonda, T. Namba, Carina Hanashima
semanticscholar +1 more source