Results 21 to 30 of about 899,641 (334)
Cbln1 regulates axon growth and guidance in multiple neural regions.
PLoS Biology, 2022 The accurate construction of neural circuits requires the precise control of axon growth and guidance, which is regulated by multiple growth and guidance cues during early nervous system development.
Peng Han +9 more
doaj +1 more source
SYD-1C, UNC-40 (DCC) and SAX-3 (Robo) function interdependently to promote axon guidance by regulating the MIG-2 GTPase. [PDF]
PLoS Genetics, 2015 During development, axons must integrate directional information encoded by multiple guidance cues and their receptors. Axon guidance receptors, such as UNC-40 (DCC) and SAX-3 (Robo), can function individually or combinatorially with other guidance ...
Yan Xu +3 more
doaj +1 more source
Scientific Reports, 2020 Intra-retinal axon guidance involves a coordinated expression of transcription factors, axon guidance genes, and secretory molecules within the retina.
Soundararajan Lalitha +9 more
semanticscholar +1 more source
Expression of Genes Involved in Axon Guidance: How Much Have We Learned?
International Journal of Molecular Sciences, 2020 Neuronal axons are guided to their target during the development of the brain. Axon guidance allows the formation of intricate neural circuits that control the function of the brain, and thus the behavior.
Sung Wook Kim, Kyong-Tai Kim
semanticscholar +1 more source
The midline protein regulates axon guidance by blocking the reiteration of neuroblast rows within the Drosophila ventral nerve cord. [PDF]
PLoS Genetics, 2013 Guiding axon growth cones towards their targets is a fundamental process that occurs in a developing nervous system. Several major signaling systems are involved in axon-guidance, and disruption of these systems causes axon-guidance defects. However, the
Mary Ann Manavalan +2 more
doaj +1 more source
SnapShot: Axon Guidance II [PDF]
Cell, 2013 BMP SE Repulsion BMP-RIB, BMP-RII - -COFILIN, LIMK1, PI3K, SMAD1, SMAD6DRAXIN SE Repulsion DCC - - -EPHRINA GPI Repulsion EPHA ADAM10 -a2-CHIMAERIN, EPHEXIN-1, NCK1/2, RAC1, RHOA, SPAR, VAV2/3EPHRINB TM Repulsion EPHB MMP2/9 -NCK1, PAK, p120GAP, RHOA, ROCK, VAV2/3EPHATM Repulsion EPHRINA ADAM10 P75 FYNAttraction EPHRINA - RET -EPHB TM Repulsion EPHRINB
R. Jeroen Pasterkamp, Alex L. Kolodkin
openaire +2 more sources
BMC Neuroscience, 2007 Background During the development of the Drosophila central nervous system the process of midline crossing is orchestrated by a number of guidance receptors and ligands.
Tomancak Pavel +3 more
doaj +1 more source
G3: Genes, Genomes, Genetics, 2018 During development, neuronal cells extend an axon toward their target destination in response to a cue to form a properly functioning nervous system.
Jamie K. Alan +4 more
doaj +1 more source
The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression
Nucleic Acids Research, 2019 N 6-Methyladenosine (m6A) is a dynamic mRNA modification which regulates protein expression in various posttranscriptional levels. Functional studies of m6A in nervous system have focused on its writers and erasers so far, whether and how m6A readers ...
Mengru Zhuang +9 more
semanticscholar +1 more source
Gastroenterology, 2019 BACKGROUND & AIMS Little is known about mechanisms of perineural invasion (PNI) by pancreatic ductal adenocarcinomas (PDAs) or other tumors. Annexin A2 (ANXA2) regulates secretion of SEMA3D, an axon guidance molecule, which binds and activates the ...
Noelle R. Jurcak +11 more
semanticscholar +1 more source