Results 31 to 40 of about 966,766 (378)

Modeling of interstitial branching of axonal networks [PDF]

, 2013
A single axon can generate branches connecting with plenty synaptic targets. Process of branching is very important for making connections in central nervous system.
Gafarov, F., Khusnutdinov, N., Suleymanov, Y.   +2 more
core   +2 more sources

Axon Guidance Molecules Promote Perineural Invasion and Metastasis of Orthotopic Pancreatic Tumors in Mice.

Gastroenterology, 2019
BACKGROUND & AIMS Little is known about mechanisms of perineural invasion (PNI) by pancreatic ductal adenocarcinomas (PDAs) or other tumors. Annexin A2 (ANXA2) regulates secretion of SEMA3D, an axon guidance molecule, which binds and activates the ...
Noelle R. Jurcak, A. Rucki, S. Muth, E. Thompson, Rajni B. Sharma, D. Ding, Qingfeng Zhu, J. Eshleman, R. Anders, E. Jaffee, K. Fujiwara, Lei Zheng   +11 more
semanticscholar   +1 more source

Transient axonal glycoprotein-1 (TAG-1) and laminin-α1 regulate dynamic growth cone behaviors and initial axon direction in vivo

Neural Development, 2008
Background How axon guidance signals regulate growth cone behavior and guidance decisions in the complex in vivo environment of the central nervous system is not well understood.
Yost H Joseph, Essner Jeffrey J, Sittaramane Vinoth K, Wolman Marc A, Chandrasekhar Anand, Halloran Mary C   +5 more
doaj   +1 more source

The Rac GTP exchange factor TIAM-1 acts with CDC-42 and the guidance receptor UNC-40/DCC in neuronal protrusion and axon guidance. [PDF]

PLoS Genetics, 2012
The mechanisms linking guidance receptors to cytoskeletal dynamics in the growth cone during axon extension remain mysterious. The Rho-family GTPases Rac and CDC-42 are key regulators of growth cone lamellipodia and filopodia formation, yet little is ...
Rafael S Demarco, Eric C Struckhoff, Erik A Lundquist   +2 more
doaj   +1 more source

With the Permission of Microtubules: An Updated Overview on Microtubule Function During Axon Pathfinding

Frontiers in Molecular Neuroscience, 2021
During the establishment of neural circuitry axons often need to cover long distances to reach remote targets. The stereotyped navigation of these axons defines the connectivity between brain regions and cellular subtypes.
Carlos Sánchez-Huertas, Eloísa Herrera
doaj   +1 more source

Cas Adaptor Proteins Coordinate Sensory Axon Fasciculation. [PDF]

, 2018
Development of complex neural circuits like the peripheral somatosensory system requires intricate mechanisms to ensure axons make proper connections. While much is known about ligand-receptor pairs required for dorsal root ganglion (DRG) axon guidance ...
Estep, Jason A, Riccomagno, Martin M, Rosette, Kylee A, Rutlin, Michael L, Vahedi-Hunter, Tyler A, Wright, Kevin M   +5 more
core   +2 more sources

A Direct Interaction of Axonin-1 with NgCAM-related Cell Adhesion Molecule (NrCAM) Results in Guidance, but not Growth of Commissural Axons [PDF]

, 2000
An interaction of growth cone axonin-1 with the floor-plate NgCAM-related cell adhesion molecule (NrCAM) was shown to play a crucial role in commissural axon guidance across the midline of the spinal cord. We now provide evidence that axonin-1 mediates a
Bovolenta, Buchstaller, Chang, Cohen, de la Rosa, Freigang, Godement, Grumet, Grumet, Grumet, Hamburger, Huber, Kayyem, Kayyem, Kennedy, Krushel, Kuhn, Kunz, Kunz, Lustig, Mason, Mauro, Morales, Moscoso, Rader, Rader, Rathjen, Rols, Serafini, Shiga, Shiga, Sonderegger, Stoeckli, Stoeckli, Stoeckli, Stoeckli, Stoeckli, Suter, Tessier-Lavigne, Thomas, Traunecker, Ulloa, Vaughn, Vielmetter, Volkmer, Wessel   +45 more
core   +5 more sources

Microfluidic control of axonal guidance [PDF]

Scientific Reports, 2014
The precision of axonal pathfinding and the accurate formation of functional neural circuitry are crucial for an organism during development as well as during adult central and peripheral nerve regeneration. While chemical cues are believed to be primarily responsible for axonal pathfinding, we hypothesize that forces due to localized fluid flow may ...
Bryan J. Black, Ankur Jain, Ling Gu, Argha Mondal, Argha Mondal, Samarendra K. Mohanty, Simon Ordonez   +6 more
openaire   +3 more sources

The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance [PDF]

, 2011
The multiprotein complexes that receive and transmit axon pathfinding cues during development are essential to circuit generation. Here, we identify and characterize the Drosophila sterile α-motif (SAM) domain-containing protein Caskin, which shares ...
Broihier, Heather T, DiAntonio, Aaron, Liu, Nan, Weng, Yi-Lan   +3 more
core   +2 more sources

Understanding axon guidance: are we nearly there yet?

Development, 2018
During nervous system development, neurons extend axons to reach their targets and form functional circuits. The faulty assembly or disintegration of such circuits results in disorders of the nervous system.
E. Stoeckli
semanticscholar   +1 more source