A Direct Interaction of Axonin-1 with NgCAM-related Cell Adhesion Molecule (NrCAM) Results in Guidance, but not Growth of Commissural Axons [PDF]
, 2000 An interaction of growth cone axonin-1 with the floor-plate NgCAM-related cell adhesion molecule (NrCAM) was shown to play a crucial role in commissural axon guidance across the midline of the spinal cord. We now provide evidence that axonin-1 mediates a
Bovolenta +45 more
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Independent signaling by Drosophila insulin receptor for axon guidance and growth
Frontiers in Physiology, 2014 The Drosophila insulin receptor (DInR) regulates a diverse array of biological processes including growth, axon guidance, and sugar homeostasis. Growth regulation by DInR is mediated by Chico, the Drosophila homolog of vertebrate insulin-receptor ...
Caroline Rita Li +2 more
doaj +1 more source
The H3K4me3/2 histone demethylase RBR-2 controls axon guidance by repressing the actin-remodeling gene wsp-1 [PDF]
, 2016 The dynamic regulation of histone modifications is important for modulating transcriptional programs during development. Aberrant H3K4 methylation is associated with neurological disorders, but how the levels and the recognition of this modification ...
Lussi, Yvonne C. +4 more
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Connecting the Retina to the Brain [PDF]
, 2014 The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Work in the laboratory of LE is funded by the BBSRC [BB/J00815X/1] and the R.S. Macdonald Charitable Trust. Research in the
Erskine, Lynda, Herrera, Eloisa
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The Ciliary Protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance
Cell Reports, 2019 Summary: The small GTPase Arl13b is enriched in primary cilia and regulates Sonic hedgehog (Shh) signaling. During neural development, Shh controls patterning and proliferation through a canonical, transcription-dependent pathway that requires the ...
Julien Ferent +8 more
doaj +1 more source
Axon guidance molecules in immunometabolic diseases
Inflammation and Regeneration, 2022 The global prevalence of metabolic diseases, such as obesity, diabetes, and atherosclerosis, is rapidly increasing and has now reached epidemic proportions.
Yoshimitsu Nakanishi +2 more
doaj +1 more source
Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis [PDF]
, 2010 The formation of the central nervous system depends on the coordinated development of neural and glial cell types that arise from a common precursor. Using an existing group of zebrafish mutants generated by viral insertion, we performed a “shelf-screen”
Abdelilah +144 more
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Requirement for Slit-1 and Robo-2 in zonal segregation of olfactory sensory neuron axons in the main olfactory bulb [PDF]
, 2007 The formation of precise stereotypic connections in sensory systems is critical for the ability to detect and process signals from the environment. In the olfactory system, olfactory sensory neurons (OSNs) project axons to spatially defined glomeruli ...
Andrews, W +4 more
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Cannabinoid receptor CB2 modulates axon guidance. [PDF]
PLoS ONE, 2013 Navigation of retinal projections towards their targets is regulated by guidance molecules and growth cone transduction mechanisms. Here, we present in vitro and in vivo evidences that the cannabinoid receptor 2 (CB2R) is expressed along the retino ...
Gabriel Duff +8 more
doaj +1 more source
Planar cell polarity genes Frizzled3a, Vangl2, and Scribble are required for spinal commissural axon guidance [PDF]
, 2016 Background A fundamental feature of early nervous system development is the guidance of axonal projections to their targets in order to assemble neural circuits that control behavior.
Purdy, Ashley M. +2 more
core +2 more sources