Results 31 to 40 of about 899,641 (334)
Neural Development, 2008 Background How axon guidance signals regulate growth cone behavior and guidance decisions in the complex in vivo environment of the central nervous system is not well understood.
Yost H Joseph +5 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2021 During the establishment of neural circuitry axons often need to cover long distances to reach remote targets. The stereotyped navigation of these axons defines the connectivity between brain regions and cellular subtypes.
Carlos Sánchez-Huertas, Eloísa Herrera
doaj +1 more source
The Rac GTP exchange factor TIAM-1 acts with CDC-42 and the guidance receptor UNC-40/DCC in neuronal protrusion and axon guidance. [PDF]
PLoS Genetics, 2012 The mechanisms linking guidance receptors to cytoskeletal dynamics in the growth cone during axon extension remain mysterious. The Rho-family GTPases Rac and CDC-42 are key regulators of growth cone lamellipodia and filopodia formation, yet little is ...
Rafael S Demarco +2 more
doaj +1 more source
Microfluidic control of axonal guidance [PDF]
Scientific Reports, 2014 The precision of axonal pathfinding and the accurate formation of functional neural circuitry are crucial for an organism during development as well as during adult central and peripheral nerve regeneration. While chemical cues are believed to be primarily responsible for axonal pathfinding, we hypothesize that forces due to localized fluid flow may ...
Bryan J. Black +6 more
openaire +3 more sources
Understanding axon guidance: are we nearly there yet?
Development, 2018 During nervous system development, neurons extend axons to reach their targets and form functional circuits. The faulty assembly or disintegration of such circuits results in disorders of the nervous system.
E. Stoeckli
semanticscholar +1 more source
A mathematical model explains saturating axon guidance responses to molecular gradients
eLife, 2016 Correct wiring is crucial for the proper functioning of the nervous system. Molecular gradients provide critical signals to guide growth cones, which are the motile tips of developing axons, to their targets.
Huyen Nguyen +4 more
semanticscholar +1 more source
Axon Guidance Molecules Guiding Neuroinflammation
Experimental Neurobiology, 2019 Axon guidance molecules (AGMs), such as Netrins, Semaphorins, and Ephrins, have long been known to regulate axonal growth in the developing nervous system. Interestingly, the chemotactic properties of AGMs are also important in the postnatal period, such
Won Suk Lee, Won-Ha Lee, Y. Bae, K. Suk
semanticscholar +1 more source
Independent signaling by Drosophila insulin receptor for axon guidance and growth
Frontiers in Physiology, 2014 The Drosophila insulin receptor (DInR) regulates a diverse array of biological processes including growth, axon guidance, and sugar homeostasis. Growth regulation by DInR is mediated by Chico, the Drosophila homolog of vertebrate insulin-receptor ...
Caroline Rita Li +2 more
doaj +1 more source
International Journal of Molecular Sciences, 2019 One of the fundamental steps during development of the nervous system is the formation of proper connections between neurons and their target cells—a process called neural wiring, failure of which causes neurological disorders ranging from autism to Down’
Sadig Niftullayev, N. Lamarche‐Vane
semanticscholar +1 more source
Guidance of retinal axons in mammals
Seminars in Cell & Developmental Biology, 2019 In order to navigate through the surrounding environment many mammals, including humans, primarily rely on vision. The eye, composed of the choroid, sclera, retinal pigmented epithelium, cornea, lens, iris and retina, is the structure that receives the light and converts it into electrical impulses.
Herrera, Eloisa +2 more
openaire +5 more sources