Signaling from Axon Guidance Receptors [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Determining how axon guidance receptors transmit signals to allow precise pathfinding decisions is fundamental to our understanding of nervous system development and may suggest new strategies to promote axon regeneration after injury or disease.
Bashaw, G., Klein, R.
openaire +3 more sources
The Role of Apoptotic Signaling in Axon Guidance
Journal of Developmental Biology, 2018 Navigating growth cones are exposed to multiple signals simultaneously and have to integrate competing cues into a coherent navigational response. Integration of guidance cues is traditionally thought to occur at the level of cytoskeletal dynamics ...
Riley Kellermeyer +3 more
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The Drosophila immunoglobulin gene turtle encodes guidance molecules involved in axon pathfinding [PDF]
, 2009 Background: Neuronal growth cones follow specific pathways over long distances in order to reach their appropriate targets. Research over the past 15 years has yielded a large body of information concerning the molecules that regulate this process.
Al-Anzi, Bader, Wyman, Robert J.
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Dystroglycan is a scaffold for extracellular axon guidance decisions
eLife, 2019 Axon guidance requires interactions between extracellular signaling molecules and transmembrane receptors, but how appropriate context-dependent decisions are coordinated outside the cell remains unclear.
L Bailey Lindenmaier +4 more
doaj +1 more source
Planar cell polarity genes Frizzled3a, Vangl2, and Scribble are required for spinal commissural axon guidance [PDF]
, 2016 Background A fundamental feature of early nervous system development is the guidance of axonal projections to their targets in order to assemble neural circuits that control behavior.
Purdy, Ashley M. +2 more
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The Caenorhabditis elegans Eph receptor activates NCK and N-WASP, and inhibits Ena/VASP to regulate growth cone dynamics during axon guidance. [PDF]
PLoS Genetics, 2012 The Eph receptor tyrosine kinases (RTKs) are regulators of cell migration and axon guidance. However, our understanding of the molecular mechanisms by which Eph RTKs regulate these processes is still incomplete.
Ahmed M Mohamed +4 more
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Loss-of-function analysis of EphA receptors in retinotectal mapping [PDF]
, 2004 Peer reviewedPublisher ...
DeChiara, Thomas M. +7 more
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Decreased expression of axon-guidance receptors in the anterior cingulate cortex in autism
Molecular Autism, 2011 Background Axon-guidance proteins play a crucial role in brain development. As the dysfunction of axon-guidance signaling is thought to underlie the microstructural abnormalities of the brain in people with autism, we examined the postmortem brains of ...
Suda Shiro +15 more
doaj +1 more source
Regulation of CNS and motor axon guidance in Drosophila by the receptor tyrosine phosphatase DPTP52F [PDF]
, 2001 Receptor-linked protein tyrosine phosphatases (RPTPs) regulate axon guidance and synaptogenesis in Drosophila embryos and larvae. We describe DPTP52F, the sixth RPTP to be discovered in Drosophila.
Knirr, Matthias +3 more
core
Predicting Axonal Response to Molecular Gradients with a Computational Model of Filopodial Dynamics [PDF]
, 2004 Axons are often guided to their targets in the developing nervous system by attractive or repulsive molecular concentration gradients. We propose a computational model for gradient sensing and directed movement of the growth cone mediated by filopodia ...
Caton A. +3 more
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