The Drosophila immunoglobulin gene turtle encodes guidance molecules involved in axon pathfinding [PDF]
, 2009 Background: Neuronal growth cones follow specific pathways over long distances in order to reach their appropriate targets. Research over the past 15 years has yielded a large body of information concerning the molecules that regulate this process.
Al-Anzi, Bader, Wyman, Robert J.
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The Caenorhabditis elegans Eph receptor activates NCK and N-WASP, and inhibits Ena/VASP to regulate growth cone dynamics during axon guidance. [PDF]
PLoS Genetics, 2012 The Eph receptor tyrosine kinases (RTKs) are regulators of cell migration and axon guidance. However, our understanding of the molecular mechanisms by which Eph RTKs regulate these processes is still incomplete.
Ahmed M Mohamed +4 more
doaj +1 more source
Src family kinases are required for limb trajectory selection by spinal motor axons [PDF]
, 2009 Signal relay by guidance receptors at the axonal growth cone is a process essential for the assembly of a functional nervous system. We investigated the in vivo function of Src family kinases (SFKs) as growth cone guidance signaling intermediates in the
Kania, Artur +2 more
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Decreased expression of axon-guidance receptors in the anterior cingulate cortex in autism
Molecular Autism, 2011 Background Axon-guidance proteins play a crucial role in brain development. As the dysfunction of axon-guidance signaling is thought to underlie the microstructural abnormalities of the brain in people with autism, we examined the postmortem brains of ...
Suda Shiro +15 more
doaj +1 more source
The cell surface receptor Tartan is a potential in vivo substrate for the receptor tyrosine phosphatase Ptp52F [PDF]
, 2009 Receptor-linked protein-tyrosine phosphatases (RPTPs) are essential regulators of axon guidance and synaptogenesis in Drosophila, but the signaling pathways in which they function are poorly defined.
Bugga, Lakshmi +2 more
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Regulation of CNS and motor axon guidance in Drosophila by the receptor tyrosine phosphatase DPTP52F [PDF]
, 2001 Receptor-linked protein tyrosine phosphatases (RPTPs) regulate axon guidance and synaptogenesis in Drosophila embryos and larvae. We describe DPTP52F, the sixth RPTP to be discovered in Drosophila.
Knirr, Matthias +3 more
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin
eLife, 2019 Developing neurons of the peripheral nervous system reach their targets via cues that support directional growth, a process known as axon guidance.
Denise M Poltavski +5 more
doaj +1 more source
Regulation of axon repulsion by MAX-1 SUMOylation and AP-3. [PDF]
, 2018 During neural development, growing axons express specific surface receptors in response to various environmental guidance cues. These axon guidance receptors are regulated through intracellular trafficking and degradation to enable navigating axons to ...
Chen, Shih-Yu +6 more
core
Differences in protein mobility between pioneer versus follower growth cones [PDF]
, 2007 Navigating growth cones need to integrate, process and respond to guidance signals, requiring dynamic information transfer within and between different compartments.
Bak +25 more
core +3 more sources