Results 41 to 50 of about 899,641 (334)
Axon guidance pathways and the control of gene expression
Developmental Dynamics, 2018 Axons need to be properly guided to their targets to form synaptic connections, and this requires interactions between highly conserved extracellular and transmembrane ligands and their cell surface receptors.
Samantha A Russell, G. Bashaw
semanticscholar +1 more source
The Caenorhabditis elegans Eph receptor activates NCK and N-WASP, and inhibits Ena/VASP to regulate growth cone dynamics during axon guidance. [PDF]
PLoS Genetics, 2012 The Eph receptor tyrosine kinases (RTKs) are regulators of cell migration and axon guidance. However, our understanding of the molecular mechanisms by which Eph RTKs regulate these processes is still incomplete.
Ahmed M Mohamed +4 more
doaj +1 more source
A pair of E3 ubiquitin ligases compete to regulate filopodial dynamics and axon guidance
bioRxiv, 2019 Appropriate axon guidance is necessary to form accurate neuronal connections. Guidance cues stimulate reorganization of the cytoskeleton within the distal growth cone at the tip of the extending axon.
N. Boyer +4 more
semanticscholar +1 more source
Autophagy, 2018 Mammalian ULK1 (unc-51 like kinase 1) and ULK2, Caenorhabditis elegans UNC-51, and Drosophila melanogaster Atg1 are serine/threonine kinases that regulate flux through the autophagy pathway in response to various types of cellular stress. C.
Bo Wang +12 more
semanticscholar +1 more source
Translating Axon Guidance Cues [PDF]
Cell, 2002 Recent studies suggest that local translation of mRNA within axons plays a key role in two aspects of growth cone navigation. One line of evidence implies a local synthesis of proteins that mediate growth cone collapse and turning in response to guidance cues; another indicates that growth cones possess the machinery that would allow the local ...
openaire +2 more sources
Dystroglycan is a scaffold for extracellular axon guidance decisions
eLife, 2019 Axon guidance requires interactions between extracellular signaling molecules and transmembrane receptors, but how appropriate context-dependent decisions are coordinated outside the cell remains unclear.
L Bailey Lindenmaier +4 more
doaj +1 more source
Neural Regeneration Research, 2019 The peripheral nervous system has an astonishing ability to regenerate following a compression or crush injury; however, the potential for full repair following a transection injury is much less.
X. Dun, D. Parkinson
semanticscholar +1 more source
Guidance Molecules in Axon Regeneration [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 The regenerative capacity of injured adult mammalian central nervous system (CNS) tissue is very limited. Disease or injury that causes destruction or damage to neuronal networks typically results in permanent neurological deficits. Injury to the spinal cord, for example, interrupts vital ascending and descending fiber tracts of spinally projecting ...
Roman J. Giger +2 more
openaire +3 more sources
Cannabinoid receptor CB2 modulates axon guidance. [PDF]
PLoS ONE, 2013 Navigation of retinal projections towards their targets is regulated by guidance molecules and growth cone transduction mechanisms. Here, we present in vitro and in vivo evidences that the cannabinoid receptor 2 (CB2R) is expressed along the retino ...
Gabriel Duff +8 more
doaj +1 more source
Dystroglycan is a scaffold for extracellular axon guidance decisions
bioRxiv, 2018 Axon guidance requires interactions between extracellular signaling molecules and transmembrane receptors, but how appropriate context-dependent decisions are coordinated outside the cell remains unclear.
L Bailey Lindenmaier +4 more
semanticscholar +1 more source