Guidance Molecules in Axon Regeneration [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 The regenerative capacity of injured adult mammalian central nervous system (CNS) tissue is very limited. Disease or injury that causes destruction or damage to neuronal networks typically results in permanent neurological deficits. Injury to the spinal cord, for example, interrupts vital ascending and descending fiber tracts of spinally projecting ...
Roman J, Giger +2 more
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A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. [PDF]
, 2012 EphB receptor tyrosine kinases control multiple steps in nervous system development. However, it remains unclear whether EphBs regulate these different developmental processes directly or indirectly.
Ataman, Bulent +12 more
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The Role of Apoptotic Signaling in Axon Guidance
Journal of Developmental Biology, 2018 Navigating growth cones are exposed to multiple signals simultaneously and have to integrate competing cues into a coherent navigational response. Integration of guidance cues is traditionally thought to occur at the level of cytoskeletal dynamics ...
Riley Kellermeyer +3 more
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The Drosophila immunoglobulin gene turtle encodes guidance molecules involved in axon pathfinding [PDF]
, 2009 Background: Neuronal growth cones follow specific pathways over long distances in order to reach their appropriate targets. Research over the past 15 years has yielded a large body of information concerning the molecules that regulate this process.
Al-Anzi, Bader, Wyman, Robert J.
core +4 more sources
Dystroglycan is a scaffold for extracellular axon guidance decisions
eLife, 2019 Axon guidance requires interactions between extracellular signaling molecules and transmembrane receptors, but how appropriate context-dependent decisions are coordinated outside the cell remains unclear.
L Bailey Lindenmaier +4 more
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The cell surface receptor Tartan is a potential in vivo substrate for the receptor tyrosine phosphatase Ptp52F [PDF]
, 2009 Receptor-linked protein-tyrosine phosphatases (RPTPs) are essential regulators of axon guidance and synaptogenesis in Drosophila, but the signaling pathways in which they function are poorly defined.
Bugga, Lakshmi +2 more
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The Caenorhabditis elegans Eph receptor activates NCK and N-WASP, and inhibits Ena/VASP to regulate growth cone dynamics during axon guidance. [PDF]
PLoS Genetics, 2012 The Eph receptor tyrosine kinases (RTKs) are regulators of cell migration and axon guidance. However, our understanding of the molecular mechanisms by which Eph RTKs regulate these processes is still incomplete.
Ahmed M Mohamed +4 more
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Src family kinases are required for limb trajectory selection by spinal motor axons [PDF]
, 2009 Signal relay by guidance receptors at the axonal growth cone is a process essential for the assembly of a functional nervous system. We investigated the in vivo function of Src family kinases (SFKs) as growth cone guidance signaling intermediates in the
Kania, Artur +2 more
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Decreased expression of axon-guidance receptors in the anterior cingulate cortex in autism
Molecular Autism, 2011 Background Axon-guidance proteins play a crucial role in brain development. As the dysfunction of axon-guidance signaling is thought to underlie the microstructural abnormalities of the brain in people with autism, we examined the postmortem brains of ...
Suda Shiro +15 more
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Mathematical guidance for axons
Trends in Neurosciences, 1998 Axon guidance by gradients plays an important role in wiring up the developing nervous system. Growth cones seem to sense a concentration difference across their spatial extent, and convert this into a signal to move up or down a gradient. In this article, a simple mathematical framework is developed to understand when and where gradient detection can ...
openaire +3 more sources