Results 211 to 220 of about 28,691 (244)

Lumbosacral Plexopathy: A Single‐Center Review of Etiology, Clinical Presentation, Electrodiagnostic Findings, and Long‐Term Outcomes

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Lumbosacral plexopathy (LSP) results from a spectrum of etiologies and can cause substantial functional impairment. Limited data exist on the relative distribution of etiologies and outcomes across broad tertiary‐care cohorts spanning multiple causes of LSP.
Bradley Ong, Jad El Ahdab, Nicolas Thompson, Yuebing Li, Nirmal Andrapalliyal   +4 more
wiley   +1 more source

Imaging patterns and genetic associations of brain atrophy across distinct symptom stages in Parkinson's disease

Neuroprotection, EarlyView.
Early disease stages showed limited cortical atrophy and enrichment of synaptic and calcium signaling pathways, whereas advanced stages demonstrated widespread cortical degeneration associated with immune activation and extracellular matrix remodeling.
Yi Ji, Liujia Lu, Kaidong Chen, Ruixuan Zhang, Yao Lu, Yachen Shi, Xiangming Fang   +6 more
wiley   +1 more source

In vivo modulation of network activity drives the nanoscale reorganisation of axo-axonic synapses at the axon initial segment

Compans B, Mastrolia V, Lenherr C, Burrone J.   +3 more
europepmc   +1 more source

Concussive Head Trauma Deranges Axon Initial Segment Function in Axotomized and Intact Layer 5 Pyramidal Neurons. [PDF]

J Neurotrauma
Harris AC, Sun J, Jacobs KM.
europepmc   +1 more source

Feedback-Driven Assembly of the Axon Initial Segment [PDF]

Neuron, 2019
The axon initial segment (AIS) is a unique neuronal compartment that plays a crucial role in the generation of action potential and neuronal polarity. The assembly of the AIS requires membrane, scaffolding, and cytoskeletal proteins, including Ankyrin-G and TRIM46. How these components cooperate in AIS formation is currently poorly understood. Here, we
Lukas Kapitein, Casper Hoogenraad, Can Yang   +2 more
exaly   +6 more sources

Activity-Dependent Plasticity of Axo-axonic Synapses at the Axon Initial Segment [PDF]

Neuron, 2020
The activity-dependent rules that govern the wiring of GABAergic interneurons are not well understood. Chandelier cells (ChCs) are a type of GABAergic interneuron that control pyramidal cell output through axo-axonic synapses that target the axon initial segment.
Guilherme Neves, Juan Burrone, Winnie Wefelmeyer   +2 more
exaly   +3 more sources

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Axonal injury alters the extracellular glial environment of the axon initial segment and allows substantial mitochondrial influx into axon initial segment

Journal of Comparative Neurology, 2021
Abstract The axon initial segment (AIS) is structurally and functionally distinct from other regions of the axon, yet alterations in the milieu of the AIS after brain injury have not been well characterized. In this study, we have examined extracellular and intracellular changes in the AIS after hypoglossal nerve ...
Hiromi Tamada, Sumiko Kiryu‐Seo, Sohgo Sawada, Hiroshi Kiyama   +3 more
openaire   +2 more sources

The Physiology of the Axon Initial Segment

Annual Review of Neuroscience, 2012
The action potential generally begins in the axon initial segment (AIS), a principle confirmed by 60 years of research; however, the most recent advances have shown that a very rich biology underlies this simple observation. The AIS has a remarkably complex molecular composition, with a wide variety of ion channels and attendant mechanisms for channel ...
Kevin J, Bender, Laurence O, Trussell
openaire   +2 more sources

The latest on the axon initial segment

2018 7th International Conference on Computers Communications and Control (ICCCC), 2018
This paper will review the latest results about the axon initial segment (AIS) revealing physiology details while focusing on the structural organization of the AIS. This highly specialized region of the axon is characterized, among others, by high concentrations of (particular) voltage-gated ion channels, and by highly specialized cytoskeletal ...
Roxana-Mariana Beiu, Virgil-Florin Duma, Valeriu Beiu   +2 more
openaire   +1 more source

The functional organization and assembly of the axon initial segment

Current Opinion in Neurobiology, 2008
Action potential initiation, modulation, and duration in neurons depend on a variety of Na+ and K+ channels that are highly enriched at the axon initial segment (AIS). The AIS also has high densities of cell adhesion molecules (CAMs), modulatory proteins, and a unique extracellular matrix (ECM).
Yasuhiro, Ogawa, Matthew N, Rasband
openaire   +2 more sources