Results 91 to 100 of about 769,118 (313)
Communications Biology, 2023 Neural progenitor cell (NPC) transplantation is a promising therapeutic strategy for replacing lost neurons following spinal cord injury (SCI). However, how graft cellular composition influences regeneration and synaptogenesis of host axon populations ...
Miriam Aceves +20 more
doaj +1 more source
Axon regeneration induced by environmental enrichment- epigenetic mechanisms
Neural Regeneration Research, 2019 Environmental enrichment is known to be beneficial for cognitive improvement. In many animal models of neurological disorders and brain injury, EE has also demonstrated neuroprotective benefits in neurodegenerative diseases and in improving recovery ...
B. Tang
semanticscholar +1 more source
Microfluidic Spinning of PEDOT:PSS Microfibers for Nerve Guidance Conduits
Advanced Materials Technologies, EarlyView.This publication explores the fabrication of microfluidically spun PEDOT:PSS microfibers for conductive nerve guidance conduits (NGCs). It details the spinning process, fiber characterization, and biocompatibility assessment. The study highlights the fibers' mechanical and electrical properties, non‐cytotoxicity, and potential for nerve regeneration or
Matthias Geiger +8 more
wiley +1 more source
Integrated brain on a chip and automated organ‐on‐chips systems
Interdisciplinary Medicine, Volume 1, Issue 1, January 2023., 2023 Organ‐on‐chips (OOCs) related to brain functions have been used in drug development and disease simulation in vitro. However, modeling of complex biological systems remains a major challenge. In this paper, the compositions of the OOCs are optimized, and an automatic integrated system model is designed. It is expected to boost life science research and
Zhe Li +3 more
wiley +1 more source
Tppp3 is a novel molecule for retinal ganglion cell identification and optic nerve regeneration
Acta Neuropathologica CommunicationsMammalian central nervous system (CNS) axons cannot spontaneously regenerate after injury, creating an unmet need to identify molecular regulators to promote axon regeneration and reduce the lasting impact of CNS injuries.
Mishal Rao +11 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2020 Irreversible blindness from glaucoma and optic neuropathies is attributed to retinal ganglion cells (RGCs) losing the ability to regenerate axons. While several transcription factors and proteins have demonstrated enhancement of axon regeneration after ...
Heather K. Mak +12 more
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Nature Communications, 2023 Extracellular matrix (ECM) deposition after central nervous system (CNS) injury leads to inhibitory scarring in humans and other mammals, whereas it facilitates axon regeneration in the zebrafish.
Julia Kolb +26 more
doaj +1 more source
Insights on Advances in 3D Bioprinting for Peripheral Nerve Regeneration
Advanced Therapeutics, EarlyView.Peripheral nerve injury is a common condition due to trauma that significantly impacts the life of the affected individual. This review explores the anatomy, classification, and pathophysiology of peripheral nerve injuries. It also discusses various types of nerve conduits and presents a detailed review of 3D bioprinted nerve conduits used in both in ...
Nasera Rizwana +5 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2020 Traumatic spinal cord injury (SCI) results in persistent functional deficits due to the lack of axon regeneration within the mammalian CNS. After SCI, chondroitin sulfate proteoglycans (CSPGs) inhibit axon regrowth via putative interactions with the LAR ...
William Rodemer +9 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2019 While it is proposed that interaction between Schwann cells and axons is key for successful nerve regeneration, the behavior of Schwann cells migrating into a nerve gap following a transection injury and how migrating Schwann cells interact with ...
Bing Chen +3 more
semanticscholar +1 more source