Results 21 to 30 of about 803,478 (378)
Frontiers in Molecular Neuroscience, 2022 Injured sensory neurons activate a transcriptional program necessary for robust axon regeneration and eventual target reinnervation. Understanding the transcriptional regulators that govern this axon regenerative response may guide therapeutic strategies
Oshri Avraham +9 more
doaj +1 more source
Axon Regeneration: A Subcellular Extension in Multiple Dimensions.
Cold Spring Harbor Perspectives in Biology, 2021 Axons are a unique cellular structure that allows for the communication between neurons. Axon damage compromises neuronal communications and often leads to functional deficits.
Carla C. Winter, Zhigang He, A. Jacobi
semanticscholar +1 more source
Cells, 2021 CNS neurons are generally incapable of regenerating their axons after injury due to several intrinsic and extrinsic factors, including the presence of axon growth inhibitory molecules. One such potent inhibitor of CNS axon regeneration is Reticulon (RTN)
Sharif Alhajlah +2 more
doaj +1 more source
A novel neutrophil subset promotes CNS neuron survival and axon regeneration
Nature Immunology, 2020 Transected axons typically fail to regenerate in the central nervous system (CNS), resulting in chronic neurological disability in individuals with traumatic brain or spinal cord injury, glaucoma and ischemia–reperfusion injury of the eye.
A. Sas +7 more
semanticscholar +1 more source
PDK1 is a negative regulator of axon regeneration
Molecular Brain, 2021 Axon regeneration in the central nervous system is inefficient. However, the neurons in the peripheral nervous system display robust regeneration after injury, indicating that axonal regeneration is differentially controlled under various conditions.
Hyemin Kim, Jinyoung Lee, Yongcheol Cho
doaj +1 more source
Migrating Schwann cells direct axon regeneration within the peripheral nerve bridge
Glia, 2020 Schwann cells within the peripheral nervous system possess a remarkable regenerative potential. Current research shows that peripheral nerve‐associated Schwann cells possess the capacity to promote repair of multiple tissues including peripheral nerve ...
Qing Min, D. Parkinson, X. Dun
semanticscholar +1 more source
GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative Diseases
Frontiers in Cell and Developmental Biology, 2020 Growth-associated protein-43 (GAP-43) and brain acid-soluble protein 1 (BASP1) regulate actin dynamics and presynaptic vesicle cycling at axon terminals, thereby facilitating axonal growth, regeneration, and plasticity.
Daayun Chung, Andrew K. Shum, G. Caraveo
semanticscholar +1 more source
Mitochondrial Behavior in Axon Degeneration and Regeneration
Frontiers in Aging Neuroscience, 2021 Mitochondria are organelles responsible for bioenergetic metabolism, calcium homeostasis, and signal transmission essential for neurons due to their high energy consumption. Accumulating evidence has demonstrated that mitochondria play a key role in axon
Biyao Wang +5 more
semanticscholar +1 more source
eLife, 2016 Axons fail to regenerate after central nervous system (CNS) injury. Modulation of the PTEN/mTORC1 pathway in retinal ganglion cells (RGCs) promotes axon regeneration after optic nerve injury.
Xinzheng Guo, William D Snider, Bo Chen
doaj +1 more source
Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH
Autophagy, 2020 Macroautophagy/autophagy is essential for maintaining cellular homeostasis through the degradation of organelles and proteins. It also has a prominent role in modulating aging.
S. Ko +3 more
semanticscholar +1 more source