Results 21 to 30 of about 50,535 (307)
Inhibiting poly(ADP-ribosylation) improves axon regeneration
eLife, 2016 The ability of a neuron to regenerate its axon after injury depends in part on its intrinsic regenerative potential. Here, we identify novel intrinsic regulators of axon regeneration: poly(ADP-ribose) glycohodrolases (PARGs) and poly(ADP-ribose ...
Alexandra B Byrne +5 more
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Normal Spastin Gene Dosage Is Specifically Required for Axon Regeneration
Cell Reports, 2012 Axon regeneration allows neurons to repair circuits after trauma; however, most of the molecular players in this process remain to be identified. Given that microtubule rearrangements have been observed in injured neurons, we tested whether microtubule ...
Michelle C. Stone +8 more
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Frontiers in Bioengineering and Biotechnology, 2020 Strategies to accelerate the rate of axon regeneration would improve functional recovery following peripheral nerve injury, in particular for cases involving segmental nerve defects.
Kritika S. Katiyar +23 more
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Lin28 Signaling Supports Mammalian PNS and CNS Axon Regeneration
Cell Reports, 2018 Summary: RNA-binding proteins Lin28a/b regulate cellular growth and tissue regeneration. Here, we investigated the role of Lin28 in the control of axon regeneration in postmitotic neurons.
Xue-Wei Wang +9 more
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Bioactive Materials, 2023 Chitosan and its degradation product, oligosaccharides, have been shown to facilitate peripheral nerve regeneration. However, the underlying mechanisms are not well understood.
Yahong Zhao +8 more
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Wolfram syndrome 1b mutation suppresses Mauthner-cell axon regeneration via ER stress signal pathway
Acta Neuropathologica Communications, 2022 Wolfram Syndrome (WS) is a fatal human inherited disease with symptoms of diabetes, vision decreasing, and neurodegeneration caused by mutations in the endoplasmic reticulum (ER)-resident protein WFS1.
Zongyi Wang +4 more
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Integrin Activation: Implications for Axon Regeneration [PDF]
Cells, 2018 Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by ‘inside–out’ and ‘outside–in’ signalling.
Menghon Cheah, Melissa Andrews
openaire +6 more sources
Frontiers in Molecular Neuroscience, 2017 Axon regeneration, fundamental to nerve repair, and functional recovery, relies on rapid changes in gene expression attributable to microRNA (miRNA) regulation.
Rongchen Huang +5 more
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rab-27 acts in an intestinal pathway to inhibit axon regeneration in C. elegans.
PLoS Genetics, 2021 Injured axons must regenerate to restore nervous system function, and regeneration is regulated in part by external factors from non-neuronal tissues.
Alexander T Lin-Moore +2 more
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iScience, 2023 Summary: Spinal motor neurons, the distinctive neurons of the central nervous system, extend into the peripheral nervous system and have outstanding ability of axon regeneration after injury.
Ye Zhu +11 more
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