Results 61 to 70 of about 803,478 (378)
Science Translational Medicine, 2019 Environmental enrichment induces activity-dependent histone acetylation via a druggable mechanism to promote recovery after spinal cord injury. An epigenetic mechanism for regenerating axons Functional recovery after spinal cord injury (SCI) is limited ...
T. Hutson +23 more
semanticscholar +1 more source
PLG Bridge Implantation in Chronic SCI Promotes Axonal Elongation and Myelination. [PDF]
, 2019 Spinal cord injury (SCI) is a devastating condition that may cause permanent functional loss below the level of injury, including paralysis and loss of bladder, bowel, and sexual function.
Anderson, Aileen J +8 more
core +1 more source
Promoting axon regeneration by inhibiting RNA N6-methyladenosine demethylase ALKBH5
eLife, 2023 A key limiting factor of successful axon regeneration is the intrinsic regenerative ability in both the peripheral nervous system (PNS) and central nervous system (CNS).
Dong Wang +7 more
doaj +1 more source
Genetic dissection of axon regeneration [PDF]
Current Opinion in Neurobiology, 2011 Axon regeneration has long been studied in vertebrate model organisms and neuronal cultures. Recent development of axon regeneration paradigms in genetic model organisms, such as Caenorhabditis elegans, Drosophila and zebrafish, has opened an exciting field for in vivo functional dissection of regeneration pathways.
Zhiping Wang, Yishi Jin, Yishi Jin
openaire +3 more sources
A sulfated carbohydrate epitope inhibits axon regeneration after injury [PDF]
, 2012 Chondroitin sulfate proteoglycans (CSPGs) represent a major barrier to regenerating axons in the central nervous system (CNS), but the structural diversity of their polysaccharides has hampered efforts to dissect the structure-activity relationships ...
Brown, Joshua M. +14 more
core +2 more sources
Required growth facilitators propel axon regeneration across complete spinal cord injury
Nature, 2018 Transected axons fail to regrow across anatomically complete spinal cord injuries (SCI) in adults. Diverse molecules can partially facilitate or attenuate axon growth during development or after injury1–3, but efficient reversal of this regrowth failure ...
Mark A. Anderson +17 more
semanticscholar +1 more source
Cell Reports, 2020 Summary: In addition to altered gene expression, pathological cytoskeletal dynamics in the axon are another key intrinsic barrier for axon regeneration in the central nervous system (CNS). Here, we show that knocking out myosin IIA and IIB (myosin IIA/B)
Xue-Wei Wang +12 more
doaj
Overexpression of Sox11 Promotes Corticospinal Tract Regeneration after Spinal Injury While Interfering with Functional Recovery [PDF]
, 2015 Embryonic neurons, peripheral neurons, and CNS neurons in zebrafish respond to axon injury by initiating pro-regenerative transcriptional programs that enable axons to extend, locate appropriate targets, and ultimately contribute to behavioral recovery ...
Blackmore, Murray G. +4 more
core +2 more sources
Increased ER–mitochondria tethering promotes axon regeneration
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Small organelles such as endoplasmic reticulum (ER) and mitochondria play key roles in cellular functions and survival. Furthermore, physical tethering between ER–mitochondria allows communication between these 2 organelles, and proteins ...
Soyeon Lee +4 more
semanticscholar +1 more source
Microtubule deacetylation sets the stage for successful axon regeneration [PDF]
, 2012 EMBO J 31: 3063–3078 Successful axon regeneration relies on a sophisticated balance between stable and dynamic microtubules. While it has been established that moderate microtubule stabilization improves regenerative performance, little is known how ...
Chen, Li, Rolls, Melissa M
core +1 more source