Results 71 to 80 of about 769,118 (313)

Genome-wide chromatin accessibility analyses provide a map for enhancing optic nerve regeneration

Scientific Reports, 2021
Retinal Ganglion Cells (RGCs) lose their ability to grow axons during development. Adult RGCs thus fail to regenerate their axons after injury, leading to vision loss.
Wolfgang Pita-Thomas, Tassia Mangetti Gonçalves, Ajeet Kumar, Guoyan Zhao, Valeria Cavalli   +4 more
doaj   +1 more source

Transduction of an immortalized olfactory ensheathing glia cell line with the green fluorescent protein (GFP) gene: evaluation of its neuroregenerative capacity as a proof of concept [PDF]

Neurosci Lett. 2016. 612:25-31
Olfactory ensheathing glia (OEG) cells are known to foster axonal regeneration of central nervous system (CNS) neurons. Several lines of reversibly immortalized human OEG (ihOEG) have been previously established that enabled to develop models for their validation in vitro and in vivo.
arxiv   +1 more source

Telomerase Reverse Transcriptase and p53 Regulate Mammalian Peripheral Nervous System and CNS Axon Regeneration Downstream of c-Myc

Journal of Neuroscience, 2019
Although several genes have been identified to promote axon regeneration in the CNS, our understanding of the molecular mechanisms by which mammalian axon regeneration is regulated is still limited and fragmented.
Jinjin Ma, X. Ju, Renjie Xu, Renjie Xu, Weihua Wang, Zong-Ping Luo, Chang-Mei Liu, Lei Yang, Bin Li, Jianquan Chen, B. Meng, Huilin Yang, F. Zhou, Saijilafu   +13 more
semanticscholar   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Fibroblast exosomal TFAP2C induced by chitosan oligosaccharides promotes peripheral axon regeneration via the miR-132-5p/CAMKK1 axis

Bioactive Materials, 2023
Chitosan and its degradation product, oligosaccharides, have been shown to facilitate peripheral nerve regeneration. However, the underlying mechanisms are not well understood.
Yahong Zhao, Jina Liu, Sha Liu, Panpan Yang, Yunyun Liang, Jinyu Ma, Susu Mao, Cheng Sun, Yumin Yang   +8 more
doaj  

Promotion of axon regeneration and protection on injured retinal ganglion cells by rCXCL2

Inflammation and Regeneration, 2023
Background In addition to rescuing injured retinal ganglion cells (RGCs) by stimulating the intrinsic growth ability of damaged RGCs in various retinal/optic neuropathies, increasing evidence has shown that the external microenvironmental factors also ...
Zi-Yuan Zhang, Zhao-Yang Zuo, Yang Liang, Si-Ming Zhang, Chun-Xia Zhang, Jing Chi, Bin Fan, Guang-Yu Li   +7 more
doaj   +1 more source

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

SnRNA-seq reveals the heterogeneity of spinal ventral horn and mechanism of motor neuron axon regeneration

iScience, 2023
Summary: Spinal motor neurons, the distinctive neurons of the central nervous system, extend into the peripheral nervous system and have outstanding ability of axon regeneration after injury.
Ye Zhu, Chengcheng Luan, Leilei Gong, Yun Gu, Xinghui Wang, Hualin Sun, Zhifeng Chen, Qiang Zhou, Chang Liu, Qi Shan, Xiaosong Gu, Songlin Zhou   +11 more
doaj  

Hydrogen peroxide promotes injury-induced peripheral sensory axon regeneration in the zebrafish skin.

PLoS Biology, 2011
Functional recovery from cutaneous injury requires not only the healing and regeneration of skin cells but also reinnervation of the skin by somatosensory peripheral axon endings.
Sandra Rieger, Alvaro Sagasti
doaj   +1 more source

A Fractional Viscoelastic Model Of The Axon In Brain White Matter [PDF]

arXiv, 2023
Traumatic axonal injury occurs when loads experienced on the tissue-scale are transferred to the individual axons. Mechanical characterization of axon deformation especially under dynamic loads however is extremely difficult owing to their viscoelastic properties.
arxiv