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Current Biology, 1992
New studies provide further evidence that the neuronal cytoskeleton is the product of a dynamic interplay between axonal transport processes and locally regulated assembly mechanisms. These data confirm that the axonal cytoskeleton in mammalian systems is largely stationary and is maintained by a smaller pool of moving subunits or polymers. Slow axonal
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New studies provide further evidence that the neuronal cytoskeleton is the product of a dynamic interplay between axonal transport processes and locally regulated assembly mechanisms. These data confirm that the axonal cytoskeleton in mammalian systems is largely stationary and is maintained by a smaller pool of moving subunits or polymers. Slow axonal
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Axonal transport in neuropathy
Muscle & Nerve, 1983AbstractRecent studies on the distribution of labeled endogenous proteins in the experimental neuropathies induced by streoptozotocin diabetes, galactose feeding, zinc pyridinethione, 2,5‐hexanedione, acrylamide, and p‐bromophenylacetylurea (BPAU) have demonstrated an impaired build up of retrogradely transported material derived from the more distal ...
J, Jakobsen, S, Brimijoin, P, Sidenius
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Axonal transport—II. Convection
Bulletin of Mathematical Biology, 1976The phenomenon of axonal transport has been well documented (Ochs, 971; Lasek, 1970; and Grafstein, 1967). In a previous paper, we showed how diffusion alone could not account for this process. In this report we show that convection or convection with diffusion can account for the observed build-up of material.
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Bulletin of Mathematical Biology, 1976
The phenomenon of axonal transport of material has been well documented (Ochs, 1971; Lasek, 1970; and Grafstein, 1967). This report seeks to establish the role of diffusion—if any—in such a transport process. We report that diffusion cannot account for the observed build-up of material as reported in the literature.
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The phenomenon of axonal transport of material has been well documented (Ochs, 1971; Lasek, 1970; and Grafstein, 1967). This report seeks to establish the role of diffusion—if any—in such a transport process. We report that diffusion cannot account for the observed build-up of material as reported in the literature.
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Axonal transport of lipid in goldfish optic axons
Neurochemical Research, 1978After injection of labeled glycerol, choline, or serine into the eye of goldfish, labeled lipids were axonally transported along the optic nerve to the optic tectum. Although the different precursors were presumably incorporated into somewhat different lipid populations, all three were approximately equally effective in labeling the lipids transported ...
J R, Currie +3 more
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2021
Abstract Axonal transport is fundamental for neuronal survival and maintenance of neuronal connectivity and synaptic function. Anterograde transport delivers membrane-bound organelles synthesized and packaged in the cell body to the axon and synaptic compartments, and also allows traffic and turnover of cytoskeletal and metabolic ...
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Abstract Axonal transport is fundamental for neuronal survival and maintenance of neuronal connectivity and synaptic function. Anterograde transport delivers membrane-bound organelles synthesized and packaged in the cell body to the axon and synaptic compartments, and also allows traffic and turnover of cytoskeletal and metabolic ...
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A paradigm for axonal transport
Neurochemical Research, 1983Axonal transport has been extensively studied for a period of 20-30 years, but there is still no general consensus concerning the mechanism by which this transport process operates. An important development in this regard is the recent studies in the physical biochemistry group in the Department of Biochemistry at Monash University where it has been ...
W D, Comper, B N, Preston, L, Austin
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1983
Intracellular movement of organelles is one of the fundamental characteristics of living cells. It is indispensable for the efficient distribution of materials and thus for the proper cellular function of eucaryotic cells, which are highly organized entities in which many functions are compartmentalized and carried out by specific substructures.
Martin E. Schwab, Hans Thoenen
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Intracellular movement of organelles is one of the fundamental characteristics of living cells. It is indispensable for the efficient distribution of materials and thus for the proper cellular function of eucaryotic cells, which are highly organized entities in which many functions are compartmentalized and carried out by specific substructures.
Martin E. Schwab, Hans Thoenen
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Axonal transport in neurological disease
Annals of Neurology, 1988AbstractThe axonal transport systems have a wide variety of primary roles and secondary responses in neurological disease processes. Recent advances in understanding these roles have built on the increasingly detailed insights into the cell biology of the axon and its supporting cells.
J W, Griffin, D F, Watson
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Axonal transport and the cytoskeleton
Current Opinion in Neurobiology, 1993Great advances in the field of axonal transport have been made in the past year, including the identification of new molecular motors associated with microtubules and actin. In addition, studies on the mechanisms of bidirectional fast axonal transport have clarified new aspects of this process, such as the isolation of a kinesin-binding protein ...
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