Results 221 to 230 of about 2,309,945 (284)

Apache is a neuronal player in autophagy required for retrograde axonal transport of autophagosomes. [PDF]

Cell Mol Life Sci
Parisi B, Esposito A, Castroflorio E, Bramini M, Pepe S, Marte A, Guarnieri FC, Valtorta F, Baldelli P, Benfenati F, Fassio A, Giovedì S.   +11 more
europepmc   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

The node of Ranvier influences the <i>in vivo</i> axonal transport of mitochondria and signaling endosomes. [PDF]

iScience
Tosolini AP, Abatecola F, Negro S, Sleigh JN, Schiavo G.   +4 more
europepmc   +1 more source

A Novel Constitutional TUBB Variant Associated With Familial Malformations of Cortical Development

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Most pathogenic tubulin variants arise de novo in sporadic patients, causing severe brain malformations and significant neurodevelopmental impairment. The resulting reproductive disadvantage typically prevents these mutations from being transmitted to offspring.
Elena Cellini, Davide Mei, Mara Cavallin, Simona Fiori, Luciana Tramacere, Maria Elena Melica, Giulia Antonelli, Simona Virdò, Elena Parrini, Renzo Guerrini   +9 more
wiley   +1 more source

Genetic Variants of Na+,K+‐ATPase Associated With Neurological Disorders: A Systematic Review

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Neurological disorders encompass a wide range of severe symptoms and manifestations, many of which are associated with genetic variants that affect ionic homeostasis. Na+,K+‐ATPase, a transmembrane enzyme responsible for maintaining electrochemical gradients in cells, plays a crucial role in neuronal excitability and brain function.
Giovana Kummer da Rosa, Leandro Rodrigo Ribeiro, Jéssica Lorena Bariviera, Mauro Schneider Oliveira   +3 more
wiley   +1 more source

Presynaptic perspective: Axonal transport defects in neurodevelopmental disorders. [PDF]

J Cell Biol
Xiong GJ, Sheng ZH.
europepmc   +1 more source

Neural Tracing Protein-Functionalized Nanoparticles Capable of Fast Retrograde Axonal Transport in Live Neurons. [PDF]

Small
Wang W, Hassan MM, Kapoor-Kaushik N, Livni L, Musrie B, Tang J, Mahmud Z, Lai S, Wich PR, Ananthanarayanan V, Moalem-Taylor G, Mao G.   +11 more
europepmc   +1 more source

Cellular and axonal transport phenotypes due to the C9ORF72 HRE in iPSC motor and sensory neurons. [PDF]

Stem Cell Reports
Scaber J, Thomas-Wright I, Clark AJ, Xu Y, Vahsen BF, Carcolé M, Dafinca R, Farrimond L, Isaacs AM, Bennett DL, Talbot K.   +10 more
europepmc   +1 more source

Innervation and cargo-specific axonal transport impairments in FUS-ALS mice with gain and loss of function

Simkin RL, Tosolini AP, Mikheenko A, Ule AM, Jin W, Kalmar B, Ahmed M, Lang Q, Lirot F, McLaughlin MF, Price G, Villarroel-Campos D, Greensmith L, Sleigh JN, Cunningham TJ, Schiavo G, Fisher EMC, Fratta P, Birsa N.   +18 more
europepmc   +1 more source

Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in aged mice

Villarroel-Campos D, Rhymes ER, Tosolini AP, Malik B, Vagnoni A, Schiavo G, Sleigh JN.   +6 more
europepmc   +1 more source