Results 151 to 160 of about 1,942 (177)

Functional Diversity of Axonemal Dyneins

2012
exaly   +2 more sources

Axonemal dyneins: assembly, organization, and regulation

Current Opinion in Cell Biology, 1996
Progress in the sequence determination of dynein subunits is providing new insights into the locations of functional domains in these microtubule motors. Combined structural and biochemical analyses of flagellar mutations are also yielding information on the three-dimensional organization of the dynein arms and on the different components that target ...
openaire   +2 more sources

Distribution of cytoplasmic and axonemal dyneins in rat tissues

Journal of Cell Science, 1992
ABSTRACT Microtubule-associated protein IC (MAP 1C) is now defined as brain cytoplasmic dynein. Recent studies have suggested that cytoplasmic dynein is a motor protein responsible for the intracellular microtubule-based motility in neuronal and non-neuronal cells.
T, Yoshida, H, Takanari, K, Izutsu
openaire   +2 more sources

Dynein, axonemal

1999
Abstract Axonemal dynein forms a double row of projections, the outer and inner arms, that are attached to the A tubule of each axonemal doublet and extend toward the B tubule of the adjacent doublet.10 The outer dynein arms are distributed along the length of the A tubule, with a constant spacing of 24 nm.
openaire   +1 more source

Dynein heavy chain isoforms and axonemal motility

Trends in Cell Biology, 1993
The translocation of dynein along microtubules is the basis for a wide variety of essential cellular movements. Dynein was first discovered in the ciliary axoneme, where it causes the directed sliding between outer doublet microtubules that underlies ciliary bending.
D J, Asai, C J, Brokaw
openaire   +2 more sources

Regulation of flagellar dynein by the axonemal central apparatus

Cell Motility, 2002
AbstractNumerous studies indicate that the central apparatus, radial spokes, and dynein regulatory complex form a signaling pathway that regulates dynein activity in eukaryotic flagella. This regulation involves the action of several kinases and phosphatases anchored to the axoneme.
openaire   +2 more sources

Axonemal dynein - a natural molecular motor

Nanotechnology, 1999
Biological motor molecules possess many of the characteristics required to power nanomachines. They can generate force and torque, transport specific cargoes over appropriate substrates, and the character and rate of their action can be controlled.
Helen C Taylor, Michael E J Holwill
openaire   +1 more source

22S axonemal dynein is preassembled and functional prior to being transported to and attached on the axonemes

Cell Motility, 1994
AbstractIn an earlier study we reported the isolation of a cytoplasmic dynein from the cytosol of Paramecium multimicronucleatum. In this study we report the isolation and characterization of two cytosolic axonemal dyneins (22S and 12S) as well as a 19S cytoplasmic dynein from the cytosol of whole or deciliated cells using preformed bovine brain ...
A K, Fok, H, Wang, A, Katayama, M S, Aihara, R D, Allen   +4 more
openaire   +2 more sources

Heterogeneity of dynein structure implies coordinated suppression of dynein motor activity in the axoneme

Journal of Structural Biology, 2012
Axonemal dyneins provide the driving force for flagellar/ciliary bending. Nucleotide-induced conformational changes of flagellar dynein have been found both in vitro and in situ by electron microscopy, and in situ studies demonstrated the coexistence of at least two conformations in axonemes in the presence of nucleotides (the apo and the nucleotide ...
Maheshwari A, Ishikawa T
openaire   +3 more sources

Analysis of the Role of Nucleotides in Axonemal Dynein Function

2009
Axonemal dynein in flagella and cilia is a motor molecule that produces microtubule sliding, powered by the energy of ATP hydrolysis. Our goal is to understand how dynein motile activity is controlled to produce the characteristic oscillatory movement of flagella.
openaire   +2 more sources