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Axonemal dyneins winch the cilium
Nature Structural & Molecular Biology, 2010In this issue, Ishikawa and colleagues provide direct evidence to support the 'winch' hypothesis for the dynein motor mechanism, in which the AAA domain motor unit is displaced parallel to the doublet microtubule long axis rather than undergoing a rotary motion.
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Dynein heavy chain isoforms and axonemal motility
Trends in Cell Biology, 1993The translocation of dynein along microtubules is the basis for a wide variety of essential cellular movements. Dynein was first discovered in the ciliary axoneme, where it causes the directed sliding between outer doublet microtubules that underlies ciliary bending.
D J, Asai, C J, Brokaw
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1999
Abstract Axonemal dynein forms a double row of projections, the outer and inner arms, that are attached to the A tubule of each axonemal doublet and extend toward the B tubule of the adjacent doublet.10 The outer dynein arms are distributed along the length of the A tubule, with a constant spacing of 24 nm.
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Abstract Axonemal dynein forms a double row of projections, the outer and inner arms, that are attached to the A tubule of each axonemal doublet and extend toward the B tubule of the adjacent doublet.10 The outer dynein arms are distributed along the length of the A tubule, with a constant spacing of 24 nm.
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Axonemal dynein - a natural molecular motor
Nanotechnology, 1999Biological motor molecules possess many of the characteristics required to power nanomachines. They can generate force and torque, transport specific cargoes over appropriate substrates, and the character and rate of their action can be controlled.
Helen C Taylor, Michael E J Holwill
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Inherently disordered regions of axonemal dynein assembly factors
Cytoskeleton, 2023AbstractThe dynein‐driven beating of cilia is required to move individual cells and to generate fluid flow across surfaces and within cavities. These motor enzymes are highly complex and can contain upwards of 20 different protein components with a total mass approaching 2 MDa.
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Axonemal dynein expression in human fetal tracheal epithelium
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2002Ciliogenesis in human fetal airway epithelium occurs from 11 to 24 gestational weeks. Using genetic and antigenic markers specific for human axonemal dynein heavy chain 9, we characterized temporal aspects of axonemal dynein expression associated with large airway epithelial ciliogenesis during human fetal development.
Johnny L, Carson +6 more
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Purification of Axonemal Dyneins and Dynein-Associated Components from Chlamydomonas
2009Axonemal dyneins are responsible for generating the force required to power ciliary and flagellar motility. These highly complex enzymes form the inner and outer arms associated with the outer doublet microtubules. They are built around one or more ~520kD heavy chains that exhibit motor activity and also include additional components that are required ...
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Does axonemal dynein push, pull, or oscillate?
Cell Motility, 2003AbstractDynein is the molecular motor that provides motive force in cilia and flagella. Dynein is anchored to the A‐subtubule of the outer doublets by a club‐shaped extension called the stem, which supports the large globular head of the molecule. Dynein forms an attachment or cross‐bridge to the B‐subtubule of the adjacent outer doublet through a ...
Charles B, Lindemann, Alan J, Hunt
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Biochemical purification of axonemal and cytoplasmic dyneins
2018Kazuo Inaba
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