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Biophysical Measurements on Axonemal Dyneins
2009In recent decades, the development of technologies such as optical trap nanometry and advanced fluorescence microscopy have provided tools for studying the dynamics of single protein molecules in vitro and in vivo with nanometer precision over timescales from milliseconds to seconds.
Hiroaki, Kojima +3 more
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Axonemal dyneins winch the cilium
Nature Structural & Molecular Biology, 2010In this issue, Ishikawa and colleagues provide direct evidence to support the 'winch' hypothesis for the dynein motor mechanism, in which the AAA domain motor unit is displaced parallel to the doublet microtubule long axis rather than undergoing a rotary motion.
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1999
Abstract Axonemal dynein forms a double row of projections, the outer and inner arms, that are attached to the A tubule of each axonemal doublet and extend toward the B tubule of the adjacent doublet.10 The outer dynein arms are distributed along the length of the A tubule, with a constant spacing of 24 nm.
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Abstract Axonemal dynein forms a double row of projections, the outer and inner arms, that are attached to the A tubule of each axonemal doublet and extend toward the B tubule of the adjacent doublet.10 The outer dynein arms are distributed along the length of the A tubule, with a constant spacing of 24 nm.
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The Axonemes of Cilia and Flagella
1991An axoneme is the specialised bundle of microtubules found within the membrane of a eukaryotic flagellum or cilium, organelles which are distinguished from one another really only on the basis of details of their modes of beating. Axonemes and basal bodies which are closely related in structure, are found throughout the animal kingdom, in algae ...
Linda A. Amos, W. Bradshaw Amos
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Regulatory role of nucleotides in axonemal function
Cell Motility, 1995AbstractAxonemal sliding involves both sliding velocity and the extent of sliding, that is how many doublets slide. It is clear that axonemes cannot beat if all doublets were to slide simultaneously, thus sliding extent is important. Using the turbidimetric assay of sliding disintegration of Tetrahymena axonemes, we examined the sliding extent and the ...
S, Kinoshita +2 more
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DynAPs and cytoplasmic assembly of axonemal dyneins
Journal of Cell ScienceABSTRACT Motile cilia are microtubule-based organelles that generate fluid flow through coordinated beating, a process powered by axonemal dynein motors. Dyneins are pre-assembled in the cytoplasm by a suite of proteins called dynein axonemal assembly factors (DNAAFs).
John B. Wallingford +3 more
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The role of axonemal components in ciliary motility
Comparative Biochemistry and Physiology Part A: Physiology, 19891. The axoneme is the detergent-insoluble cytoskeleton of the cilium. 2. All axonemes generate movement by the same fundamental mechanism: microtubule sliding utilizing ATP hydrolysis during a mechanochemical cycling of dynein arms on the axonemal doublets. 3.
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Axonemal dyneins: assembly, organization, and regulation
Current Opinion in Cell Biology, 1996Progress in the sequence determination of dynein subunits is providing new insights into the locations of functional domains in these microtubule motors. Combined structural and biochemical analyses of flagellar mutations are also yielding information on the three-dimensional organization of the dynein arms and on the different components that target ...
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Regulation of sperm motility at the axonemal level
Reproduction, Fertility and Development, 1995With very few exceptions, the basic structure of the 9+2 axoneme has been well preserved over a very long period of evolution from protozoa to mammais. This stability indicates that the basic structural components of the axoneme visible by electron microscopy, as well as most of the other unidentified components, have withstood the passage of time.
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Structural biology of cytoplasmic and axonemal dyneins
Journal of Structural Biology, 2012Dyneins are microtubule-based, ATP-driven motor proteins with six tandemly linked AAA+ domains, a long N-terminal tail and a coiled-coil stalk. Cytoplasmic dyneins function as individual homodimers and are responsible for minus-end-oriented transport along microtubules. Axonemal dyneins of flagella/cilia are anchored in arrays to peripheral microtubule
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