Results 61 to 70 of about 1,059 (150)

Mussels Increase Xenobiotic (Azaspiracid) Toxicity Using a Unique Bioconversion Mechanism

, 2016
Azaspiracid Poisoning (AZP) is a human toxic syndrome which is associated with the consumption of bivalve shellfish. Unlike other shellfish, mussels contain a large array of azaspiracid analogs, many of which are suspected bioconversion products.
Frank N. A. M. van Pelt (2215744), Zuzana Škrabáková (2215738), Daniel O’Driscoll (2215747), Kevin J. James (2215741), John O’Halloran (2215750)   +4 more
core   +1 more source

Photodynamic therapy for cancer: mechanisms, photosensitizers, nanocarriers, and clinical studies

MedComm, Volume 5, Issue 7, July 2024.
We highlight the development and molecular mechanisms underlying the activation of photosensitizers, the challenges of PDT in tumor management, and the advantages of nanocarriers‐based PDT against cancer. Abstract Photodynamic therapy (PDT) is a temporally and spatially precisely controllable, noninvasive, and potentially highly efficient method of ...
Wanchen Zhao, Liqing Wang, Meihong Zhang, Zhiqi Liu, Chuanbin Wu, Xin Pan, Zhengwei Huang, Chao Lu, Guilan Quan   +8 more
wiley   +1 more source

Biological Effects of the Azaspiracid-Producing Dinoflagellate Azadinium dexteroporum in Mytilus galloprovincialis from the Mediterranean Sea

Marine Drugs, 2019
Azaspiracids (AZAs) are marine biotoxins including a variety of analogues. Recently, novel AZAs produced by the Mediterranean dinoflagellate Azadinium dexteroporum were discovered (AZA-54, AZA-55, 3-epi-AZA-7, AZA-56, AZA-57 and AZA-58) and their ...
Maria Elisa Giuliani, Stefano Accoroni, Marica Mezzelani, Francesca Lugarini, Simone Bacchiocchi, Melania Siracusa, Tamara Tavoloni, Arianna Piersanti, Cecilia Totti, Francesco Regoli, Rachele Rossi, Adriana Zingone, Stefania Gorbi   +12 more
doaj   +1 more source

Distribution and abundance of azaspiracid-producing dinophyte species and their toxins in North Atlantic and North Sea waters in summer 2018.

PLoS ONE, 2020
Representatives of the marine dinophyte family Amphidomataceae produce lipophilic phycotoxins called azaspiracids (AZA) which may cause azaspiracid shellfish poisoning (AZP) in humans after consumption of contaminated seafood.
Stephan Wietkamp, Bernd Krock, Dave Clarke, Daniela Voß, Rafael Salas, Jane Kilcoyne, Urban Tillmann   +6 more
doaj   +1 more source

Scientific opinion on marine biotoxins in shellfish in the Republic of Croatia

Food Risk Assess Europe, Volume 2, Issue 2, April 2024.
Summary Marine biotoxins are thermostable, mostly non‐protein molecules with different chemical components. According to solubility, they are divided into water‐soluble (hydrophilic) and fat‐soluble (lipophilic). The regulations of the EU and the Republic of Croatia regarding the maximum limits (ML) in live shellfish cover several groups: azaspiracids (
Brigita Hengl, Jasenka Petrić, Andrea Gross – Bošković, Ivana Ujević, Eddy Listeš, Tanja Bogdanović, Natalija Džafić, Kristina Kvrgić   +7 more
wiley   +1 more source

Total Synthesis and Structural Elucidation of Azaspiracid-1. Construction of Key Building Blocks for Originally Proposed Structure

, 2016
Syntheses of the three key building blocks (65, 98, and 100) required for the total synthesis of the proposed structure of azaspiracid-1 (1a) are described. Key steps include a TMSOTf-induced ring-closing cascade to form the ABC rings of tetracycle 65, a
David Sarlah (1617298), Noriaki Uesaka (2650006), Nicole Diedrichs (2650009), Michael O. Frederick (2112859), Goran Petrovic (2648464), Eriketi Loizidou (2649997), Petri M. Pihko (1702507), Ning Zou (2650000), Wenyuan Qian (1522009), Manuela Rodriquez (1266213), Federico Bernal (2501692), Theocharis V. Koftis (2648461), K. C. Nicolaou (1332141), Jürgen Hinrichs (2650003)   +13 more
core   +2 more sources

New insights into the causes of human illness due to consumption of azaspiracid contaminated shellfish [PDF]

, 2015
Azaspiracid (AZA) poisoning was unknown until 1995 when shellfish harvested in Ireland caused illness manifesting by vomiting and diarrhoea. Further in vivo/vitro studies showed neurotoxicity linked with AZA exposure.
Graham, S.F., Botana, L.M., Alonso, E., Campbell, K.; id_orcid, Graham, S. F., Campbell, K., Silke, J., Botana, L. M., Elliott, C. T., Botana López, Luis Miguel, Chevallier, O. P., Duffy, C., Chevallier, O.P., Chevallier, Olivier P., Elliot, Christopher T., Elliott, C.T.   +15 more
core   +1 more source

Total synthesis and structural elucidation of azaspiracid-1 : construction of key building blocks for originally proposed structure

, 2006
Syntheses of the three key building blocks (65, 98, and 100) required for the total synthesis of the proposed structure of azaspiracid-1 (1a) are described. Key steps include a TMSOTf-induced ring-closing cascade to form the ABC rings of tetracycle 65, a
Qian, W., Pihko, P., Bernal, F., Loizidou, E., Uesaka, N., Rodriquez, M., Nicolaou, K., Diedrichs, N., Hinrichs, J., Zou, N., Sarlah, D., Frederick, M., Koftis, T., Petrovic, G.   +13 more
core   +2 more sources

Azaspiracid Shellfish Poisoning: A Review on the Chemistry, Ecology, and Toxicology with an Emphasis on Human Health Impacts

Marine Drugs, 2008
Azaspiracids (AZA) are polyether marine toxins that accumulate in various shellfish species and have been associated with severe gastrointestinal human intoxications since 1995.
Gregory J. Doucette, Philipp Hess, Nils Rehmann, Michael J. Twiner   +3 more
doaj  

Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin

, 2009
Azaspiracid-2 was isolated from a marine sponge Echinoclathria sp. collected off Amami-Oshima as the predominant cytotoxic constituent. A combination of HPLC using ODS, GS320, and Phenylhexyl stationary phases permitted the purification without using ...
Ueoka, R., Yoshida, M., Maeda, S., van Soest, R.W.M., Matsunaga, S., Takagi, M., Ito, A., Izumikawa, M., Shin-ya, K.   +8 more
core   +1 more source