Results 91 to 100 of about 8,323 (256)

Organocatalyzed asymmetric [2+2] cycloaddition of saccharin-derived endocyclic ketimines and allenoates for the synthesis of fused azetidines

Tetrahedron Chem
We report a novel enantioselective [2 + 2] cycloaddition of allenoate and endocyclic ketimine derived from saccharin, catalyzed by a chiral tertiary amine.
Xinyu Liu, Yunfeng Zhang, Luning Zhou, Dehai Li, De Wang   +4 more
doaj   +1 more source

Lipid Nanoparticles in Drug Delivery: Overcoming Challenges and Unlocking New Frontiers

Small Structures, Volume 7, Issue 3, March 2026.
Lipid nanoparticles (LNPs) have revolutionized nucleic acid delivery, yet challenges in formulation, stability, and targeted efficacy persist. This review explores how advances in microfluidic manufacturing, precision targeting, and endosomal escape are reshaping LNP design.
Jordan Kambanis, Lauren A. Lowe, Jingyi Yao, Zhenxu Yang, Shaoxue Zeng, Ken‐Tye Yong, Ling Zhu, Yi Shen   +7 more
wiley   +1 more source

Studies on Azetidine Derivatives. I. Synthesis of 3-Substituted Azetidine Derivatives

Chemical and Pharmaceutical Bulletin, 1974
In order to find pharmacologically active azetidine derivatives, convenient procedures for the synthesis of 3-substituted azetidines have been investigated. 3-Azetidinyl mesylates (IV), prepared by treatment of azetidin-3-ols (I) with sulfenes, were shown to be useful intermediates for the synthesis of 3-substituted azetidines, 3-amino-, 3-cyano-, 3 ...
TETSUYA OKUTANI, TATSUHIKO KANEKO, KATSUTADA MASUDA   +2 more
openaire   +2 more sources

A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova, Thomas M. Geiger, Lorenzo Cianni, Dominika E. Pieńkowska, Jan Gerhartz, Lina Read, Aleša Bricelj, Alexander Herrmann, Maurice Leon Nelles, Yuen Lam Dora Ng, Marcus D. Hartmann, Jan Krönke, Izidor Sosič, Radosław P. Nowak, Michael Gütschow, Christian Steinebach   +15 more
wiley   +1 more source

Recent advances in the late-stage modification of complex bioactive molecules with oxetanes and azetidines

Tetrahedron Chem
Oxetanes and azetidines have emerged as increasingly prominent motifs in medicinal chemistry, offering compact, polar frameworks that finely modulate the physicochemical properties of drug candidates.
Yuqing Wang, Dayu Tian, Hai-Jun Zhang
doaj   +1 more source

New 3,3-disubstituted oxetanes and azetidines: Synthesis, evaluation and new opportunities for drug discovery [PDF]

, 2020
3,3-Disubstituted oxetanes and azetidines are valuable motifs with attractive physichochemical properties and are potential replacement groups for gem-dimethyl, carbonyls and larger heterocycles. The development of robust methods to access such scaffolds
Dubois, Maryne Andrée Jacqueline
core   +1 more source

Synthesis of Substituted Cyclic Amines From Protected Amino Acids Using Oxidative Decarboxylation and Alkylation

Asian Journal of Organic Chemistry, Volume 15, Issue 2, February 2026.
Simple access to alkylated 3D scaffold via oxidative radical decarboxylation, trapping of iminium, and successive reaction with organometallic reagent in the presence of BF3 . ABSTRACT Cyclic amines are vital scaffolds in bioactive molecules and drug discovery, often functionalized via electrochemical Shono‐type oxidation to access N‐acyliminium ...
Dario Corbisiero, Arthur F. Rossignol, Francesco Calogero, Andrea Gualandi, Emanuele Pinosa, Luca Sensoli, Paolo Ronchi, Pier Giorgio Cozzi   +7 more
wiley   +1 more source

Recent advances in fluorescent materials innovation and film‐based sensing application

Responsive Materials, Volume 4, Issue 1, February 2026.
This review systematically summarizes recent advances in high‐performance film‐based fluorescent sensors (FFSs), specifically covering the innovative strategies for engineering porous sensing films, and the sensitive and rapid detection for diverse target analytes. Current challenges for the further development of the sensors are discussed, guiding the
Xinyu Gou, Junxia Peng, Yu Fang
wiley   +1 more source

Synthesis of optically active 1,2,3-trisubstituted azetidines employing an organocatalytic approach with L-proline [PDF]

, 2013
A concise organocatalytic approach towards optically active 1,2,3-trisubstituted azetidines, including a study of the scope and limitations of the synthetic sequence, is reported.
Amongero, Marcela, Kaufman, Teodoro Saul
core   +2 more sources

The Nitrofuran-Warhead-Equipped Spirocyclic Azetidines Show Excellent Activity against Mycobacterium tuberculosis

Molecules
A series of 21 new 7′H-spiro[azetidine-3,5′-furo [3,4-d]pyrimidine]s substituted at the pyrimidine ring second position were synthesized. The compounds showed high antibacterial in vitro activity against M. tuberculosis.
Kristina Komarova, Lyubov Vinogradova, Alexey Lukin, Maxim Zhuravlev, Dmitry Deniskin, Mikhail Chudinov, Maxim Gureev, Marine Dogonadze, Natalia Zabolotnykh, Tatiana Vinogradova, Anastasia Lavrova, Petr Yablonskiy   +11 more
doaj   +1 more source