Revealing nascent proteomics in signaling pathways and cell differentiation. [PDF]
, 2018 Regulation of gene expression at the level of protein synthesis is a crucial element in driving how the genetic landscape is expressed. However, we are still limited in technologies that can quantitatively capture the immediate proteomic changes that ...
Burlingame, Alma L +8 more
core +1 more source
Structural Determinants of Alkyne Reactivity in Copper-Catalyzed Azide-Alkyne Cycloadditions
Molecules, 2016 This work represents our initial effort in identifying azide/alkyne pairs for optimal reactivity in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions.
Xiaoguang Zhang, Peiye Liu, Lei Zhu
doaj +1 more source
Synthesis of 1,2,3-triazole functionalized hyperbranched poly(ethyleneimine) and its use as multifunctional anionic macroinitiator for diglycidyl ether of bisphenol A curing [PDF]
, 2016 Hyperbranched poly(ethyleneimine) (PEI) has been modified by the addition of propargyl acrylate following a Michael addition reaction. On this polymer (PEI-yne) a copper (I)-catalyzed azide alkyne cycloaddition (CuAAC) has been performed to obtain a ...
Acebo Gorostiza, Cristina +4 more
core +2 more sources
Microwave-assisted three-component domino reaction: Synthesis of indolodiazepinotriazoles
Beilstein Journal of Organic Chemistry, 2013 A microwave-assisted three-component protocol involving N-1 alkylation of 2-alkynylindoles with epichlorohydrin, ring opening of the epoxide with sodium azide, and an intramolecular Huisgen azide–internal alkyne 1,3-dipolar cycloaddition domino sequence ...
Rajesh K. Arigela +3 more
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A strained alkyne-containing bipyridine reagent ; synthesis, reactivity and fluorescence properties [PDF]
, 2019 We report the synthesis of a bipyridyl reagent containing a strained alkyne, which significantly restricts its flexibility. Upon strain-promoted alkyne-azide cycloaddition (SPAAC) with an azide, which does not require a Cu catalyst, the structure becomes
Chmel, Nikola Paul +5 more
core +1 more source
Safirinium Fluorescent “Click” Molecular Probes: Synthesis, CuAAC Reactions, and Microscopic Imaging
MoleculesFluorescent labeling utilizing Cu(I)-catalyzed azide–alkyne cycloaddition reactions (CuAAC) is among the leading applications of the “click” chemistry strategy.
Patryk Kasza +10 more
doaj +1 more source
CXCR4-targeted and MMP-responsive iron oxide nanoparticles for enhanced magnetic resonance imaging [PDF]
, 2014 MRI offers high spatial resolution with excellent tissue penetration but it has limited sensitivity and the commonly administered contrast agents lack specificity.
Aboagye, EO +7 more
core +1 more source
Clickable azide-functionalized bromoarylaldehydes – synthesis and photophysical characterization
Beilstein Journal of Organic Chemistry, 2020 Herein, we present a facile synthesis of three azide-functionalized fluorophores and their covalent attachment as triazoles in Huisgen-type cycloadditions with model alkynes.
Dominik Göbel +3 more
doaj +1 more source
Surface Modification of Melt Extruded Poly(ε-caprolactone) Nanofibers: Toward a New Scalable Biomaterial Scaffold. [PDF]
, 2014 A photochemical modification of melt-extruded polymeric nanofibers is described. A bioorthogonal functional group is used to decorate fibers made exclusively from commodity polymers, covalently attach fluorophores and peptides, and direct cell growth ...
Baer, Eric +5 more
core +2 more sources
SynOpen, 2018 A range of bis-heterocyclic derivatives based on novel morpholinone and triazole heterocycles was prepared from iodo-morpholinone. The key step in our strategy is a one-pot procedure based upon copper-catalysed alkyne-azide cycloaddition (CuAAC) from ...
A. Mayooufi +2 more
doaj +1 more source