Results 131 to 140 of about 227,350 (349)

Electronic Structure of the Azide Group in 3¢-Azido-3¢-deoxythymidine (AZT) Compared to Small Azide Compounds

open access: yesMolecules, 2009
Theoretical calculations for some structural and electronic properties of the azide moiety in the nucleoside reverse transcriptase (RT) inhibitor 3¢-azido-3¢-deoxythymidine (AZT) are reported.
Feng Wang, Fang-Fang Chen
doaj   +1 more source

Adjusting Cell‐Surface Interactions Through a Covalent Immobilization of Biomolecules

open access: yesAdvanced Materials Interfaces, EarlyView.
This review presents an overview of current and emerging immobilization techniques coupled with an in‐depth investigation of the underlying mechanisms governing the activity and stability of covalently immobilized biomolecules. The aim of this study is to serve as a guide for the development of long‐lasting biomedical coatings with versatile biological
Sara Shakibania   +2 more
wiley   +1 more source

Controlling Frost Propagation on Polymeric Surfaces Using SI‐ATRP Chemical Micropatterning

open access: yesAdvanced Materials Interfaces, EarlyView.
Local wettability differences on the polymeric substrates grafted with hydrophilic stripes are linked to local variations in the presence and state of molecular water layer (MWL). The localized MWL results in fast‐propagating freezing events on the hydrophilic stripes followed by slower freezing propagation across the more hydrophobic substrate, thus ...
Miisa J. Tavaststjerna   +2 more
wiley   +1 more source

Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology

open access: yesMolecules, 2013
Click chemistry is a powerful chemical reaction with excellent bioorthogonality features: biocompatible, rapid and highly specific in biological environments.
Xiu Zhang, Yan Zhang
doaj   +1 more source

Mechanical deformation of monocytic THP-1 cells : occurrence of two seqential phases with differential sensitivity to metabolic inhibitors [PDF]

open access: yesExperimental Biology Online - EBO 2 (1997) 5, 2007
Blood leukocytes can exhibit extensive morphological changes during their passage through small capillary vessels. The human monocytic THP-1 cell line was used to explore the metabolic dependence of these shape changes. Cells were aspirated into micropipettes for determination of the rate of protrusion formation.
arxiv  

Extracellular Vesicle Crosslinkers Constructing Hydrogels with Stress‐Relaxation and Bioactive Protein Modification

open access: yesAdvanced Materials Interfaces, EarlyView.
Extracellular vesicles (EVs) are functionalized and used as crosslinkers to construct hydrogels, compatible with common crosslinking chemistries in biomaterial scaffolds. EV crosslinkers provided stress relaxation properties, promoting cell growth. They also enabled efficient protein delivery while maintaining biological activity, as VEGF‐loaded EV ...
Lufeng Shi   +14 more
wiley   +1 more source

Brønsted acid-promoted azide–olefin [3 + 2] cycloadditions for the preparation of contiguous aminopolyols: The importance of disiloxane ring size to a diastereoselective, bidirectional approach to zwittermicin A

open access: yesBeilstein Journal of Organic Chemistry, 2010
We report the first study of substrate-controlled diastereoselection in a double [3 + 2] dipolar cycloaddition of benzyl azide with α,β-unsaturated imides.
Hubert Muchalski   +2 more
doaj   +1 more source

5-Azido-4-dimethylamino-1-methyl-1,2,4-triazolium Hexafluoridophosphate and Derivatives

open access: yesCrystals, 2016
5-Azido-4-(dimethylamino)-1-methyl-1,2,4-triazolium hexafluoridophosphate was synthesized from the corresponding 5-bromo compound with NaN3. Reaction with bicyclo[2.2.1]hept-2-ene yielded a tricyclic aziridine, addition of an N-heterocyclic carbene ...
Gerhard Laus   +2 more
doaj   +1 more source

Recent progress in the synthesis of six-membered aminocyclitols (2008-2017) [PDF]

open access: yes, 2018
Aminocyclitols are of interest as glucosidase inhibitors, as probes for the study of pseudoglycosyltransferases, and as potential therapeutics for the treatment of Gaucher’s disease.
Donaldson, William
core   +1 more source

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