Results 111 to 120 of about 18,329 (303)

Electrolyte–Framework Matching in High‐Voltage TEMPO‐COF Cathodes for Lithium Batteries

Advanced Science, EarlyView.
TEMPO‐functionalized covalent organic frameworks are investigated as high‐voltage cathodes for lithium batteries. Screening five electrolyte anions identifies lithium difluoro(oxalato)borate (LiDFOB) as the optimal electrolyte, balancing capacity, rate capability, and cycling stability, while buckypaper electrodes achieve high mass loading (40 mg cm−2)
Marilyn Esclance DMello, Nagaraj Patil, Fanni Fekecs, Sergio Pinilla, Rebeca Marcilla, Manuel Souto   +5 more
wiley   +1 more source

Nitrogen-Centered Radicals Derived from Azidonucleosides

Molecules
Azido-modified nucleosides have been extensively explored as substrates for click chemistry and the metabolic labeling of DNA and RNA. These compounds are also of interest as precursors for further synthetic elaboration and as therapeutic agents.
Yahaira Reyes, Amitava Adhikary, Stanislaw F. Wnuk   +2 more
doaj   +1 more source

Continuous multistep synthesis of 2-(azidomethyl)oxazoles

Beilstein Journal of Organic Chemistry, 2018
An efficient three-step protocol was developed to produce 2-(azidomethyl)oxazoles from vinyl azides in a continuous-flow process. The general synthetic strategy involves a thermolysis of vinyl azides to generate azirines, which react with bromoacetyl ...
Thaís A. Rossa, Nícolas S. Suveges, Marcus M. Sá, David Cantillo, C. Oliver Kappe   +4 more
doaj   +1 more source

Enantioselective Synthesis Using Azides: Mechanism And Methods

, 2020
University of Minnesota Ph.D. dissertation. May 2020. Major: Chemistry. Advisor: Joseph Topczewski. 1 computer file (PDF); x, 176 pages.With the increasing demand of complex sp3-hybridized molecules and the importance of sustainability and ...
Ott, Amy
core  

Efficient Amidation from Carboxylic Acids and Azides via Selenocarboxylates:  Application to the Coupling of Amino Acids and Peptides with Azides

, 2016
A facile one-pot procedure for the coupling of carboxylic acid and azide via selenocarboxylate and selenatriazoline has been developed and successfully applied to the coupling of amino acids and peptides with azides.
Longqin Hu (2507563), Xinghua Wu (640505)   +1 more
core   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Scalable and practical synthesis of clickable Cu-chelating azides

, 2017
A convenient synthetic access to chelating azides enabled the preparation of efficient clickable fluorescent derivatives. The comparison of their reactivity to regular azides showcased the superiority of such derivatives for labeling applications.
F. Taran, S. Bregant, C. Chollet, A. Sallustrau, D. Audisio   +4 more
core   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

A Sustainable Synthetic Approach to Tacrine and Cholinesterase Inhibitors in Deep Eutectic Solvents under Aerobic Conditions

Molecules
An enhanced, sustainable, and efficient method for synthesizing tacrine, achieving a 98% yield, has been developed by replacing volatile organic compounds with more eco-friendly solvents such as deep eutectic solvent (DESs). The optimized protocol scales
Luciana Cicco, Filippo Maria Perna, Vito Capriati, Paola Vitale   +3 more
doaj   +1 more source

Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS) in Glioblastoma

Advanced Science, EarlyView.
ABSTRACT Glioblastoma (GBM) remains one of the most challenging brain malignancies due to the restrictive nature of the blood–brain barrier (BBB), which severely limits effective drug and gene delivery. To overcome this, we introduce Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS), a modular platform that enables safe ...
Gulsah Erel‐Akbaba, Jinyoung Park, Achal Duhoon, Cao Thuy Giang Nguyen, Nitu Bhaskar, Sumanta Kumar Karan, Hasan Akbaba, Parbeen Singh, Thi Bao Tram Tran, Yuhui Zhu, Zhiming Li, I'jaaz Muhammad, Xiaojun Zhang, Hoang Quan Truong, A. Daniel Davidar, Elizabeth Schmitzer, Vikas N. Vattipally, Angelica F. Lopez, Patrick Kramer, Victor M. Quiroz, Ben Bykov, Claire Hao, Amir Manbachi, Nicholas Theodore, Joshua C. Doloff, Thanh D. Nguyen   +25 more
wiley   +1 more source