Results 101 to 110 of about 18,930 (288)

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

open access: yesAdvanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang   +19 more
wiley   +1 more source

Iodine Azide, Bromine Azide and Mercuric Azide

open access: yesJournal of Synthetic Organic Chemistry, Japan, 1970
Hiromichi OHTA, Masayuki YOSHIDA
openaire   +3 more sources

A unified model of impact sensitivity of metal azides [PDF]

open access: yes, 2019
A comprehensive theoretical study of 18 metal azides is reported. Herein, the first theoretical model of impact sensitivity is developed which can safely distinguish sensitive and insensitive (alkali) metal azides.
Bondarchuk, S. V.
core   +1 more source

EFFECTS OF MECHANICAL FAULT IN THE ENERGETICALLY ACTIVE WHISKERS

open access: yesВестник Кемеровского государственного университета, 2014
The paper considers the results on flexural deformation detected by the authors in whiskers of lead azides and potassium nitrate when exposed to light, electric field and temperature.
F. I. Ivanov, E. V. Isakova
doaj  

Direct C-H amination of arenes with alkyl azides under rhodium catalysis

open access: yes, 2013
New horizons in the utility of azides: The rhodium-catalyzed intermolecular direct C-H amination of arenes with alkyl azides provides a convenient route to N-alkyl anilines (see scheme; DG=directing group).
Kwangmin Shin   +5 more
core   +1 more source

Sequential Patterning of Photoresponsive Hydrogels Directs Crypt Fission and Reveals the Role of Epithelial Curvature on Fission Symmetry

open access: yesAdvanced Science, EarlyView.
Deterministic crypt fission is achieved in intestinal organoids using photopatternable hydrogels with spatiotemporal control. Daughter‐crypt symmetry is shown to depend on parent‐crypt geometry and epithelial curvature, while myosin‐dependent mechanosensing links tissue shape to regenerative outcomes.
Delaney L. McNally   +8 more
wiley   +1 more source

Synthesis of Amides and Nitriles from Vinyl Azides and p‑Quinone Methides

open access: yes, 2017
A divergent synthesis of amides and nitriles from vinyl azides and p-quinone methides (p-QMs) was developed. The p-QMs could be activated by BF3-Et2O and then nucleophilically attacked by vinyl azides, leading to divergent rearrangement toward amides and
Chen Lin (95910)   +4 more
core   +1 more source

Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure

open access: yesAdvanced Science, EarlyView.
Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye   +6 more
wiley   +1 more source

Nitrogen-Centered Radicals Derived from Azidonucleosides

open access: yesMolecules
Azido-modified nucleosides have been extensively explored as substrates for click chemistry and the metabolic labeling of DNA and RNA. These compounds are also of interest as precursors for further synthetic elaboration and as therapeutic agents.
Yahaira Reyes   +2 more
doaj   +1 more source

Iron–Phosphine Complex-Catalyzed Intramolecular C(sp3)–H Amination of Azides

open access: yes, 2020
Fe­(II)–phosphine complex [Fe­(dpbz)]­Cl2 was demonstrated to be effective for the intramolecular C­(sp3)–H amination of organic azides. This catalyst exhibited a high catalytic capacity for the transformations from α-azido amides to imidazolinones ...
Wei Yu (43094)   +3 more
core   +1 more source

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