Results 1 to 10 of about 56,531 (323)

Combinations of posaconazole and tacrolimus are effective against infections with azole-resistant Aspergillus fumigatus [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundSolid organ transplant recipients on immunosuppressants such as tacrolimus are at increased risk of developing pulmonary aspergillosis, a severe to deadly complication with limited treatment options, especially against azole-resistant strains ...
Eliane Vanhoffelen, Tine Van Win, Eva Van Braeckel, Eva Van Braeckel, Agustin Reséndiz-Sharpe, Bruno P. A. Cammue, Bruno P. A. Cammue, Katrien Lagrou, Katrien Lagrou, Karin Thevissen, Greetje Vande Velde   +10 more
doaj   +2 more sources

High incidence of azole resistance among Candida albicans and C. glabrata isolates in Northeastern Iran [PDF]

Current Medical Mycology, 2021
Background and Purpose: Resistance to antifungal drugs is increasing among Candida isolates from patients with vulvovaginal candidiasis (VVC). Lack of correct diagnosis of Candida causing VVC and the experimental use of antifungal drugs are the main ...
Hossein Zarrinfar, Zahra Kord, Abdolmajid Fata   +2 more
doaj   +1 more source

Coordinated Regulation of Membrane Homeostasis and Drug Accumulation by Novel Kinase STK-17 in Response to Antifungal Azole Treatment

Microbiology Spectrum, 2022
The emergence of antifungal resistance, especially to the most widely used azole class of ergosterol biosynthesis inhibitors, makes fungal infections difficult to treat in clinics and agriculture. When exposed to azoles, fungi can make adaptive responses
Chengcheng Hu, Mi Zhou, Xianhe Cao, Wei Xue, Zhenying Zhang, Shaojie Li, Xianyun Sun   +6 more
doaj   +1 more source

Case Report: Hypercalcemia as a manifestation of acute adrenal crisis precipitated by fluconazole use, and a review of the literature

Frontiers in Endocrinology, 2023
Acute adrenal crisis classically presents with vomiting, altered sensorium, and hypotension. We describe a unique case manifesting with severe hypercalcemia. Addisonian crisis was unusually precipitated by fluconazole use.
Kuan Swen Choo, Jielin Yew, Eberta Jun Hui Tan, Troy Hai Kiat Puar   +3 more
doaj   +1 more source

Antifungal Activity of Minocycline and Azoles Against Fluconazole-Resistant Candida Species

Frontiers in Microbiology, 2021
Candida species are the most common fungal pathogens to infect humans, and can cause life-threatening illnesses in individuals with compromised immune systems.
Jingwen Tan, Shaojie Jiang, Lihua Tan, Haiyan Shi, Lianjuan Yang, Yi Sun, Xiuli Wang   +6 more
doaj   +1 more source

Oceanapiside, a Marine Natural Product, Targets the Sphingolipid Pathway of Fluconazole-Resistant Candida glabrata

Marine Drugs, 2021
Oceanapiside (OPS), a marine natural product with a novel bifunctional sphingolipid structure, is fungicidal against fluconazole-resistant Candida glabrata at 10 μg/mL (15.4 μM).
Doralyn S. Dalisay, Evan W. Rogers, Tadeusz F. Molinski   +2 more
doaj   +1 more source

Uncovering New Mutations Conferring Azole Resistance in the Aspergillus fumigatus cyp51A Gene

Frontiers in Microbiology, 2020
The opportunistic pathogen Aspergillus fumigatus has developed worldwide resistance to azoles largely through mutations in cytochromeP450 enzyme Cyp51.
Peiying Chen, Musang Liu, Musang Liu, Qiuqiong Zeng, Zheng Zhang, Weida Liu, Weida Liu, Hong Sang, Ling Lu   +8 more
doaj   +1 more source

High-Throughput Chemical Screen Identifies a 2,5-Disubstituted Pyridine as an Inhibitor of Candida albicans Erg11

mSphere, 2022
Fungal infections contribute to over 1.5 million deaths annually, with Candida albicans representing one of the most concerning human fungal pathogens. While normally commensal in nature, compromise of host immunity can result in C.
Antonia C. Du Bois, Alice Xue, Chester Pham, Nicole M. Revie, Kirsten J. Meyer, Yoko Yashiroda, Charles Boone, Justin R. Nodwell, Peter Stogios, Alexei Savchenko, Nicole Robbins, Kali R. Iyer, Leah E. Cowen   +12 more
doaj   +1 more source

Trichophyton: Changing nomenclature and practical implications

Indian Journal of Dermatology, 2023
Trichophyton interdigitale had been regarded as anthropophilic, mainly causing non-inflammatory tinea unguium and tinea pedis. T. mentagrophytes, thought to be zoophilic, were regarded as responsible for more inflammatory dermatophytosis.
Manas Chatterjee, Debatri Datta
doaj   +1 more source

Impact of TR₃₄/L98H, TR₄₆/Y121F/T289A and TR₅₃ Alterations in Azole-Resistant Aspergillus fumigatus on Sterol Composition and Modifications after In Vitro Exposure to Itraconazole and Voriconazole

Microorganisms, 2022
Background: Sterols are the main components of fungal membranes. Inhibiting their biosynthesis is the mode of action of azole antifungal drugs that are widely used to treat fungal disease including aspergillosis.
Rose-Anne Lavergne, Marjorie Albassier, Jean-Benoît Hardouin, Carlos Alvarez-Moreno, Fabrice Pagniez, Florent Morio, Patrice Le Pape, Isabelle Ourliac-Garnier   +7 more
doaj   +1 more source