Results 91 to 100 of about 58,246 (290)

Repurposing Azoles to Resolve Serotogenic Toxicity Associated with Linezolid to Combat Multidrug-Resistant Tuberculosis [PDF]

, 2023
Rukaiyya T. Girase, Iqrar Ahmad, Jong‐Min Oh, Hoon Kim, Bijo Mathew, Vagolu Siva Krishna, Tone Tønjum, Nisheeth C. Desai, Dharmarajan Sriram, Jyothi Kumari, Harun Patel   +10 more
openalex   +1 more source

A new method to measure EC50 reveals cultivar‐specific fungicide resistance and very high diversity within experimental field populations of Zymoseptoria tritici

Pest Management Science, EarlyView.
We isolated Zymoseptoria tritici strains from a diverse wheat field and quantified fungicide resistance using a novel plate assay. We found high diversity in fungicide sensitivity and host–fungicide–pathogen interactions. Abstract BACKGROUND Zymoseptoria tritici causes Septoria tritici blotch (STB), the most damaging wheat disease in Europe. In Europe,
Firas Talas, Jessica Stapley, Bruce A McDonald   +2 more
wiley   +1 more source

Azole Resistance in Aspergillus fumigatus: A Consequence of Antifungal Use in Agriculture?

Frontiers in Microbiology, 2017
Agricultural industry uses pesticides to optimize food production for the growing human population. A major issue for crops is fungal phytopathogens, which are treated mainly with azole fungicides.
Sarah Berger, Yassine El Chazli, Ambrin F. Babu, Alix T. Coste   +3 more
doaj   +1 more source

Fungicide Resistance Genetics of Apple Scab fungus Venturia inaequalis [PDF]

, 2015
Apple scab, caused by the ascomycete fungus Venturia inaequalis, is considered the most devastating disease on domestic apple crops. Apples are the most important cultivated crop in temperate regions and the United States produced about 4.6 million tons ...
Reddel, Alexis LT
core   +1 more source

Sensitivity to demethylation‐inhibiting fungicides and induced expression of CYP51 associated with tebuconazole resistance in Alternaria species on mandarin in Brazil

Pest Management Science, EarlyView.
Tebuconazole‐resistant isolates overexpress CYP51 and, when tested at field rates, did not reduce ABS severity, whereas difenoconazole and mefentrifluconazole remained effective. Abstract BACKGROUND Alternaria brown spot (ABS), caused by Alternaria spp., is an important disease affecting mandarin production in several citrus‐growing regions worldwide ...
Thiago de Aguiar Carraro, Yong Luo, Boris X. Camiletti, Themis J. Michailides, Victor Gabri, Geraldo José Silva‐Junior, Lilian Amorim, Louise Larissa May De Mio   +7 more
wiley   +1 more source

Selectivity improvement of an azole inhibitor of CYP707A by replacing the monosubstituted azole with a disubstituted azole

Bioorganic & Medicinal Chemistry Letters, 2010
The plant growth-retardant uniconazole (UNI), a triazole inhibitor of gibberellin biosynthetic enzyme (CYP701A), inhibits multiple P450 enzymes including ABA 8'-hydroxylase (CYP707A), a key enzyme in ABA catabolism. Azole P450 inhibitors bind to a P450 active site by both coordinating to the heme-iron atom via sp2 nitrogen and interacting with ...
Yasushi, Todoroki, Kumi, Naiki, Hikaru, Aoyama, Minaho, Shirakura, Kotomi, Ueno, Masaharu, Mizutani, Nobuhiro, Hirai   +6 more
openaire   +2 more sources

In vitro evaluation of azole fungicide sensitivity in Fusarium langsethiae, F. tricinctum, F. poae and F. sporotrichioides populations from Irish oats

Pest Management Science, EarlyView.
Microtitre plate assays of 286 Irish oat isolates show species‐specific azole sensitivity. In Fusarium langsethiae, mefentrifluconazole and tebuconazole sensitivities correlate, defining four phenotypes and supporting resistance monitoring and integrated control.
Diana E. Bucur, Steven Kildea
wiley   +1 more source

Combined antifungal resistance and biofilm tolerance: the global threat of Candida auris [PDF]

, 2019
The enigmatic yeast Candida auris has emerged over the last decade and rapidly penetrated our consciousness. The global threat from this multidrug-resistant yeast has generated a call to arms from within the medical mycology community.
Kean, Ryan, Ramage, Gordon
core   +2 more sources

Azole-ResistantAspergillus fumigatus, Iran

Emerging Infectious Diseases, 2013
To the Editor: Aspergillus fumigatus causes a variety of diseases in humans. The drugs recommended for treatment of Aspergillus diseases are the mold-active azole antifungal drugs (1). However, a wide range of mutations in A. fumigatus confer azole resistance, which commonly involves modifications in the cyp51A gene (2), the target for azole antifungal
Seyedmousavi, S., Hashemi, S.J., Zibafar, E., Zoll, J., Hedayati, M.T., Mouton, J.W., Melchers, W.J.G., Verweij, P.E.   +7 more
openaire   +5 more sources

Challenges facing the management of pesticide resistance in weeds, diseases and insect pests in European agriculture and the future of effective IPM implementation

Pest Management Science, EarlyView.
Opinion on pesticide resistance and management in the European Union (EU) and United Kingdom (UK) is presented cognisant of changes in regulation that impact on mode of action availability and cropping system choice. Abstract In recent times, pesticide resistance has been managed reasonably effectively, either proactively or reactively, by monitoring ...
Julian Smith, Bianca Assis Barbosa Martins, Roland Beffa, Linda M Field, Andreas Goertz, Gael Le Goupil, Andreas Mehl, Juergen Langewald, Samuel Martinelli, Caio Vitagliano Santi Rossi, John A Wiles   +10 more
wiley   +1 more source