Results 131 to 140 of about 58,246 (290)
Predicting the Stability of Base‐mediated C─H Carboxylation Adducts Using Data Science Tools
Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.A computational approach integrating quantum chemistry and machine learning enables the prediction of CO2–adduct stability. Model interpretability and experimental validation highlight its utility for designing base‐mediated C–H carboxylation reactions.
Maike Eckhoff +6 more
wiley +2 more sources
Model Informed Precision Dosing of Tacrolimus in Children Following Heart Transplant
The Journal of Clinical Pharmacology, Volume 66, Issue 2, February 2026.Abstract Tacrolimus is a first‐line immunosuppressant used after solid organ transplantation that suffers from extensive intra‐ and inter‐patient variability and a narrow therapeutic window. Its critical role in a fragile population, coupled with the difficulties identifying and maintaining an appropriate dose within a given patient, make it an ideal ...
Jadon S. Wagstaff +3 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.Fluorescent probes derived from all three clinically used polyene antifungals (amphotericin B, nystatin, and natamycin) enabled direct visualization of distribution in yeast cells of various Candida species. While retaining the ergosterol‐dependent mode of action of their parent drugs, the probes revealed distinct, structure‐specific localization ...
Melissa Shbeta +6 more
wiley +2 more sources
Vaginal azoles versus oral fluconazole in treatment of recurrent vulvovaginal candidiasis [PDF]
Background: Vulvovaginal candidiasis (VVC) is a fungal infection of the vagina and vulva. It is usually caused by Candida albicans, however, occasionally other candida species are responsible. The optimal treatment of VVC has not yet been defined.
تلو, مهشید +3 more
core
Caspofungin activity against clinical isolates of azole cross-resistant Candida glabrata overexpressing efflux pump genes [PDF]
, 2017 Objectives: Several studies have documented the potent in vitro activity of caspofungin against Candida spp. This is of special concern for Candida glabrata infections that are often resistant to many azole antifungal agents and, consequently, difficult ...
Fadda, Giovanni +6 more
core
P028 To Study the Susceptibility of Caspofungin in Azole Resistant Candidemia of High-Risk Neonates of Nicu by E-STRIP (MIC) Method andTime to Think for Preventive Measures [PDF]
, 2022 Anugula. Amritha, Manjula Vagarali
openalex +1 more source
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 2, February 2026.ABSTRACT Background Gender‐affirming testosterone therapy is one part of the standard of care for more than 1 million transgender adults in the United States. Testosterone therapy may influence the activities of drug‐metabolizing enzymes and transporters, but knowledge about its effect on the pharmacokinetics of other medications is limited.
Michiko Hunter +9 more
wiley +1 more source
mBioAzoles are the primary antifungal drugs used to treat infections caused by Aspergillus fumigatus. However, the emergence of azole resistance in A. fumigatus has become a global health concern despite the low proportion of resistant isolates in natural ...
Shu Chen +8 more
doaj +1 more source
Pentazole and Ammonium Pentazolate: Crystalline Hydro-Nitrogens at High Pressure
, 2017 Two new crystalline compounds, pentazole (N_{5}H) and ammonium pentazolate (NH_{4})(N_{5}), both featuring cyclo-{\rm N_{5}^{-}} are discovered using first principles evolutionary search of the nitrogen-rich portion of the hydro-nitrogen binary phase ...
Oleynik, Ivan I., Steele, Brad A.
core +4 more sources
Diazocarbonyl and Related Compounds in the Synthesis of Azoles [PDF]
, 2021 Anton Budeev +3 more
openalex +1 more source