Results 131 to 140 of about 72,034 (334)

A Systematic Review of Synthetic and Anticancer and Antimicrobial Activity of Quinazoline/Quinazolin‐4‐one Analogues

ChemistryOpen, EarlyView.
Quinazoline represents an important class of heterocycles with diverse medicinal and pharmacological significance. This review systematically examines scholarly efforts toward understanding different synthetic pathways emphasizing the role of metal and non‐metal catalysts including some miscellaneous reagents employed in the synthesis of quinazoline ...
Neha Manhas, Gobind Kumar, Sanjeev Dhawan, Talent Makhanya, Parvesh Singh   +4 more
wiley   +1 more source

Trichophyton rubrum Azole Resistance Mediated by a New ABC Transporter, TruMDR3

Antimicrobial Agents and Chemotherapy, 2019
The mechanisms of terbinafine resistance in a set of clinical isolates of Trichophyton rubrum have been studied recently. Of these isolates, TIMM20092 also showed reduced sensitivity to azoles.
M. Monod, M. Feuermann, K. Salamin, M. Fratti, M. Makino, M. Alshahni, K. Makimura, Tsuyoshi Yamada   +7 more
semanticscholar   +1 more source

Recent trends in molecular diagnostics of yeast infections : from PCR to NGS [PDF]

, 2019
The incidence of opportunistic yeast infections in humans has been increasing over recent years. These infections are difficult to treat and diagnose, in part due to the large number and broad diversity of species that can underlie the infection.
Arastehfar, A, Boekhout, T, Buda De Cesare, G, Butler, G, Dolk, E, Gabaldón, Tony, Hafez, A, Hagen, F, Hovhannisyan, H, Hube, B, Iracane, E, Kostrzewa, M, Lackner, M, Lass-Flörl, C, Llorens, C, Mixão, V, Munro, C, Oliveira-Pacheco, J, OPATHY Consortium, the, Pekmezovic, M, Pérez-Hansen, A, Rodriguez Sánchez, Antonio, Sauer, FM, Sparbier, K, Stavrou, AA, Vaneechoutte, Mario, Vatanshenassan, M   +26 more
core   +2 more sources

Evaluation of the Antifungal Properties of Azomethine‐Pyrazole Derivatives from a Structural Perspective

ChemistryOpen, EarlyView.
A series of azomethine‐pyrazole derivatives bearing a para‐substituted azo‐phenyl ring is straightforwardly prepared. The new compounds display an elevated antifungal activity against various Candida species and Cryptococcus neoformans strains. DFT and molecular docking calculations are used to determine possible routes of action through interactions ...
María Isabel Murillo, Andrés Camilo Restrepo‐Acevedo, Cristian Rocha‐Roa, Susana Zacchino, Laura Svetaz, Simón Hernández‐Ortega, Rodrigo Abonia, Ronan Le Lagadec, Fernando Cuenú‐Cabezas   +8 more
wiley   +1 more source

Variability in competitive fitness among environmental and clinical azole-resistant Aspergillus fumigatus isolates

mBio
Azoles are the primary antifungal drugs used to treat infections caused by Aspergillus fumigatus. However, the emergence of azole resistance in A. fumigatus has become a global health concern despite the low proportion of resistant isolates in natural ...
Shu Chen, Guoxing Zhu, Huiping Lin, Jian Guo, Shuwen Deng, Wenjuan Wu, Gustavo H. Goldman, Ling Lu, Yuanwei Zhang   +8 more
doaj   +1 more source

Systematic review of topical treatments for fungal infections of the skin and nails of the feet [PDF]

, 1999
OBJECTIVE: To identify and synthesise the evidence for efficacy and cost effectiveness of topical treatments for superficial fungal infections of the skin and nails of the feet. DESIGN: Systematic review. INTERVENTIONS: Topical treatments for superficial
Bell-Syer, Sally E.M., Crawford, Fay, Hart, Rachel, Russell, Ian, Torgerson, David J., Young, Philip   +5 more
core   +2 more sources

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Effects of Agricultural Fungicide Use on Aspergillus fumigatus Abundance, Antifungal Susceptibility, and Population Structure

mBio, 2020
Antibiotic resistance is an increasing threat to human health. In the case of Aspergillus fumigatus, which is both an environmental saprobe and an opportunistic human fungal pathogen, resistance is suggested to arise from fungicide use in agriculture, as
Amelia E. Barber, Jennifer Riedel, Tongta Sae-Ong, Kang Kang, Werner Brabetz, Gianni Panagiotou, Holger B. Deising, Oliver Kurzai   +7 more
doaj   +1 more source

First azole‐resistant Aspergillus fumigatus isolates with the environmental TR46/Y121F/T289A mutation in Iran

Mycoses (Berlin), 2020
Azole resistance in Aspergillus fumigatus is an emerging problem and reported from all continents. As triazole antifungals are the mainstay of therapy in the management of invasive aspergillosis, azole‐resistant A fumigatus has become a major medical ...
F. Ahangarkani, Ynze Puts, M. Nabili, S. Khodavaisy, M. Moazeni, Z. Salehi, Melika Laal Kargar, H. Badali, J. Meis   +8 more
semanticscholar   +1 more source

Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator. [PDF]

, 2014
BackgroundPowdery mildew, caused by the obligate biotrophic fungus Erysiphe necator, is an economically important disease of grapevines worldwide. Large quantities of fungicides are used for its control, accelerating the incidence of fungicide-resistance.
Amrine, Katherine CH, Cantu, Dario, Gubler, W Douglas, Jones, Laura, McGuire, Brianna, Morales-Cruz, Abraham, Riaz, Summaira, Walker, M Andrew   +7 more
core   +2 more sources