Results 21 to 30 of about 72,034 (334)
Frontiers in Endocrinology, 2023 Acute adrenal crisis classically presents with vomiting, altered sensorium, and hypotension. We describe a unique case manifesting with severe hypercalcemia. Addisonian crisis was unusually precipitated by fluconazole use.
Kuan Swen Choo +3 more
doaj +1 more source
Mycoses (Berlin), 2022 Azole resistance complicates treatment of patients with invasive aspergillosis with an increased mortality. Azole resistance in Aspergillus fumigatus is a growing problem and associated with human and environmental azole use.
M. Risum +14 more
semanticscholar +1 more source
Characterizing and contrasting structural proton transport mechanisms in azole hydrogen bond networks using ab initio molecular dynamics [PDF]
J. Phys. Chem. Lett. 2021, 12, 36, 8749-8756, 2021 Imidazole and 1,2,3-triazole are promising hydrogen-bonded heterocycles that conduct protons via a structural mechanism and whose derivatives are present in systems ranging from biological proton channels to proton exchange membrane fuel cells. Here, we leverage multiple time-stepping to perform ab initio molecular dynamics of imidazole and 1,2,3 ...
arxiv +1 more source
Mechanisms of azole antifungal resistance in clinical isolates of Candida tropicalis
PLoS ONE, 2022 This study was designed to understand the molecular mechanisms of azole resistance in Candida tropicalis using genetic and bioinformatics approaches. Thirty-two azole-resistant and 10 azole-susceptible (S) clinical isolates of C.
S. Paul +6 more
semanticscholar +1 more source
mSphere, 2022 Fungal infections contribute to over 1.5 million deaths annually, with Candida albicans representing one of the most concerning human fungal pathogens. While normally commensal in nature, compromise of host immunity can result in C.
Antonia C. Du Bois +12 more
doaj +1 more source
Deciphering the Mrr1/Mdr1 Pathway in Azole Resistance of Candida auris
Antimicrobial Agents and Chemotherapy, 2022 Candida auris is an emerging yeast pathogen with a remarkable ability to develop antifungal resistance, in particular to fluconazole and other azoles. Azole resistance in C.
Jizhou Li +4 more
semanticscholar +1 more source
Marine Drugs, 2021 Oceanapiside (OPS), a marine natural product with a novel bifunctional sphingolipid structure, is fungicidal against fluconazole-resistant Candida glabrata at 10 μg/mL (15.4 μM).
Doralyn S. Dalisay +2 more
doaj +1 more source
Frustration on a centred pyrochlore lattice in metal-organic frameworks [PDF]
Phys. Rev. Research 5, L022018 (2023), 2022 Geometric frustration inhibits magnetic systems from ordering, opening a window to unconventional phases of matter. The paradigmatic frustrated lattice in three dimensions to host a spin liquid is the pyrochlore, although there remain few experimental compounds thought to realize such a state.
arxiv +1 more source
Antimicrobial Agents and Chemotherapy, 2022 Fungal infections are a major health concern because of limited antifungal drugs and development of drug resistance. Candida can develop azole drug resistance by overexpression of drug efflux pumps or mutating ERG11, the target of azoles.
Kortany M. Baker +9 more
semanticscholar +1 more source
Trichophyton: Changing nomenclature and practical implications
Indian Journal of Dermatology, 2023 Trichophyton interdigitale had been regarded as anthropophilic, mainly causing non-inflammatory tinea unguium and tinea pedis. T. mentagrophytes, thought to be zoophilic, were regarded as responsible for more inflammatory dermatophytosis.
Manas Chatterjee, Debatri Datta
doaj +1 more source