Sensitivity towards DMI fungicides and haplotypic diversity of their CYP51 target in the Mycosphaerella graminicola population of Flanders [PDF]
, 2014 Septoria leaf blotch, caused by the fungus Mycosphaerella graminicola, is the most important wheat disease in Northwestern Europe, and is currently controlled by fungicide applications.
Curvers, Katrien +4 more
core +1 more source
Fungal Resistance to Echinocandins and the MDR Phenomenon in Candida glabrata
Journal of Fungi, 2018 Candida glabrata has thoroughly adapted to successfully colonize human mucosal membranes and survive in vivo pressures. prior to and during antifungal treatment. Out of all the medically relevant Candida species, C.
Kelley R. Healey, David S. Perlin
doaj +1 more source
Augmenting Azoles with Drug Synergy to Expand the Antifungal Toolbox
Pharmaceuticals, 2022 Fungal infections impact the lives of at least 12 million people every year, killing over 1.5 million. Wide-spread use of fungicides and prophylactic antifungal therapy have driven resistance in many serious fungal pathogens, and there is an urgent need ...
Aidan Kane, Dee A. Carter
doaj +1 more source
Absent in vitro interaction between chloroquine and antifungals against Aspergillus fumigatus [PDF]
, 2017 This work was supported by Medical Mycology Section, Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Seyedmousavi, Seyedmojtaba +3 more
core +1 more source
Crystals, 2011 The crystal and molecular structure of the title compound, viz., (2Z)-2-[3-(4-methoxybenzoyl)-4,4-dimethyl-1,2,-oxazolidin-2-ylidene]-1-(4-methoxyphenyl)ethanone (4), is reported.
Robert A. Gossage +4 more
doaj +1 more source
Carbonic Anhydrase II Activators in Osteopetrosis Treatment: A Review
Current Issues in Molecular Biology, 2023 Osteopetrosis is a rare hereditary illness generated by failure in osteoclasts resulting in elevated bone densities. Patients with osteopetrosis possess several complications, like dental caries, earlier teeth loss, delayed eruption, malformed crowns and
Zikra Alkhayal +3 more
doaj +1 more source
Antifungal Resistance and Synergistic Therapy in Candida Spp. Isolated From Bottlenose Dolphins Under Human Care: Implications for One Health Management. [PDF]
Vet Med SciCandida spp. isolated from bottlenose dolphins under human care showed multirug resistance to common azoles. In vitro synergy testing revealed that certain antifungal combinations improved efficacy against resistant strains. Environmental monitoring using FISH detected Candida spp.
Biancani B +6 more
europepmc +2 more sources
Bioorganic & Medicinal Chemistry Letters, 2010 The plant growth-retardant uniconazole (UNI), a triazole inhibitor of gibberellin biosynthetic enzyme (CYP701A), inhibits multiple P450 enzymes including ABA 8'-hydroxylase (CYP707A), a key enzyme in ABA catabolism. Azole P450 inhibitors bind to a P450 active site by both coordinating to the heme-iron atom via sp2 nitrogen and interacting with ...
Minaho Shirakura +6 more
openaire +3 more sources
Azole potentiation in Candida species
PLOS Pathogens, 2023 Fungal infections are rising, with over 1.5 billion cases and more than 1 million deaths recorded each year. Among these, Candida infections are frequent in at-risk populations and the rapid development of drug resistance and tolerance contributes to their clinical persistence.
Stenkiewicz-Witeska, Jan, Ene, Iuliana
openaire +5 more sources
Evaluation of combination therapy for Burkholderia cenocepacia lung infection in different in vitro and in vivo models [PDF]
, 2017 Burkholderia cenocepacia is an opportunistic pathogen responsible for life-threatening infections in cystic fibrosis patients. B. cenocepacia is extremely resistant towards antibiotics and therapy is complicated by its ability to form biofilms.
Brackman, Gilles +10 more
core +12 more sources