Results 31 to 40 of about 72,034 (334)

Azole Use in Agriculture, Horticulture, and Wood Preservation – Is It Indispensable?

open access: yesFrontiers in Cellular and Infection Microbiology, 2021
Plant pathogens cause significant damage to plant products, compromising both quantities and quality. Even though many elements of agricultural practices are an integral part of reducing disease attacks, modern agriculture is still highly reliant on ...
L. N. Jørgensen, T. Heick
semanticscholar   +1 more source

Novel ERG11 and TAC1b Mutations Associated with Azole Resistance in Candida auris

open access: yesAntimicrobial Agents and Chemotherapy, 2021
Candida auris is a novel Candida species that has spread in all continents, causing nosocomial outbreaks of invasive candidiasis. C. auris has the ability to develop resistance to all antifungal drug classes. Notably, many C. auris isolates are resistant
Jizhou Li   +5 more
semanticscholar   +1 more source

Duration of cytopenias with concomitant venetoclax and azole antifungals in acute myeloid leukemia

open access: yesCancer, 2021
Venetoclax (VEN) combined with the hypomethylating agent (HMA) azacitidine improves survival in patients aged ≥75 years with newly diagnosed acute myeloid leukemia (AML).
C. Rausch   +23 more
semanticscholar   +1 more source

[Final accepted version, unedited] Understanding the Environmental Drivers of Clinical Azole Resistance in Aspergillus Spp.

open access: yesDrug Target Insights, 2022
Aspergilli are ubiquitous fungal pathogens associated with several life-threatening infections, especially in immunocompromised patients. Azoles are the first line of treatment for most Aspergillus related infections.
Pooja Sen   +4 more
doaj   +1 more source

Impact of TR34/L98H, TR46/Y121F/T289A and TR53 Alterations in Azole-Resistant Aspergillus fumigatus on Sterol Composition and Modifications after In Vitro Exposure to Itraconazole and Voriconazole

open access: yesMicroorganisms, 2022
Background: Sterols are the main components of fungal membranes. Inhibiting their biosynthesis is the mode of action of azole antifungal drugs that are widely used to treat fungal disease including aspergillosis.
Rose-Anne Lavergne   +7 more
doaj   +1 more source

Extensive Genetic Diversity and Widespread Azole Resistance in Greenhouse Populations of Aspergillus fumigatus in Yunnan, China

open access: yesMsphere, 2021
The origin and prevalence of azole-resistant Aspergillus fumigatus have been attracting increasing attention from biologists, clinicians, and public health agencies. Current evidence suggests agricultural fungicide use as a major cause.
Duanyong Zhou   +10 more
semanticscholar   +1 more source

Hospital Environment as a Source of Azole-Resistant Aspergillus fumigatus Strains with TR34/L98H and G448S Cyp51A Mutations

open access: yesJournal of Fungi, 2021
Azole-resistant Aspergillus fumigatus is an emerging worldwide problem with increasing reports of therapy failure cases produced by resistant isolates. A case of azole-resistant A.
Irene Gonzalez-Jimenez   +4 more
doaj   +1 more source

A robust Th-azole framework for highly efficient purification of C2H4 from a C2H4/C2H2/C2H6 mixture

open access: yesNature Communications, 2020
Separation of C2H4 from C2H4/C2H2/C2H6 mixture with high working capacity is still a challenging task. Herein, we deliberately design a Th-metal-organic framework (MOF) for highly efficient separation of C2H4 from a binary C2H6/C2H4 and ternary C2H4/C2H2/
Z. Xu   +7 more
semanticscholar   +1 more source

The C2H2 Transcription Factor SltA Contributes to Azole Resistance by Coregulating the Expression of the Drug Target Erg11A and the Drug Efflux Pump Mdr1 in Aspergillus fumigatus

open access: yesAntimicrobial Agents and Chemotherapy, 2021
The emergence of azole-resistant fungal pathogens has posed a great threat to public health worldwide. Although the molecular mechanism of azole resistance has been extensively investigated, the potential regulators of azole resistance remain largely ...
Wenlong Du   +5 more
semanticscholar   +1 more source

Recognition of Azole-Resistant Aspergillosis by Physicians Specializing in Infectious Diseases, United States

open access: yesEmerging Infectious Diseases, 2018
Infections caused by pan–azole-resistant Aspergillus fumigatus strains have emerged in Europe and recently in the United States. Physicians specializing in infectious diseases reported observing pan–azole-resistant infections and low rates of ...
Tiffany A. Walker   +8 more
doaj   +1 more source

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