Results 31 to 40 of about 58,246 (290)

Synthesis of Novel Thiazole Derivatives Bearing β-Amino Acid and Aromatic Moieties as Promising Scaffolds for the Development of New Antibacterial and Antifungal Candidates Targeting Multidrug-Resistant Pathogens

Molecules, 2021
Rapidly growing antimicrobial resistance among clinically important bacterial and fungal pathogens accounts for high morbidity and mortality worldwide.
Dovilė Malūkaitė, Birutė Grybaitė, Rita Vaickelionienė, Giedrius Vaickelionis, Birutė Sapijanskaitė-Banevič, Povilas Kavaliauskas, Vytautas Mickevičius   +6 more
doaj   +1 more source

Differentially Regulated Transcription Factors and ABC Transporters in a Mitochondrial Dynamics Mutant Can Alter Azole Susceptibility of Aspergillus fumigatus

Frontiers in Microbiology, 2020
Azole resistance of the fungal pathogen Aspergillus fumigatus is an emerging problem. To identify novel mechanisms that could mediate azole resistance in A.
Laura Sturm, Bernadette Geißel, Ronny Martin, Ronny Martin, Johannes Wagener, Johannes Wagener, Johannes Wagener   +6 more
doaj   +1 more source

CYP51 Mutations in the Fusarium solani Species Complex: First Clue to Understand the Low Susceptibility to Azoles of the Genus Fusarium

Journal of Fungi, 2022
Members of Fusarium solani species complex (FSSC) are cosmopolitan filamentous fungi responsible for invasive fungal infections in immunocompromised patients.
Pierre Vermeulen, Arnaud Gruez, Anne-Lyse Babin, Jean-Pol Frippiat, Marie Machouart, Anne Debourgogne   +5 more
doaj   +1 more source

Fungal Resistance to Echinocandins and the MDR Phenomenon in Candida glabrata

Journal of Fungi, 2018
Candida glabrata has thoroughly adapted to successfully colonize human mucosal membranes and survive in vivo pressures. prior to and during antifungal treatment. Out of all the medically relevant Candida species, C.
Kelley R. Healey, David S. Perlin
doaj   +1 more source

An Erg11 lanosterol 14-α-demethylase-Arv1 complex is required for Candida albicans virulence.

PLoS ONE, 2020
Azole resistant fungal infections remain a health problem for the immune compromised. Current therapies are limited due to rises in new resistance mechanisms.
Michelle L Villasmil, Antonio Daniel Barbosa, Jessie Lee Cunningham, Symeon Siniossoglou, Joseph T Nickels   +4 more
doaj   +1 more source

Absent in vitro interaction between chloroquine and antifungals against Aspergillus fumigatus [PDF]

, 2017
This work was supported by Medical Mycology Section, Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Seyedmousavi, Seyedmojtaba, van der Lee, Henrich, Verweij, Paul, Warris, Adilia   +3 more
core   +1 more source

The Crystal and Molecular Structure of (2Z)-2-[3-(4-Methoxybenzoyl)-4,4-dimethyl-1,2-oxazolidin-2-ylidene]-1-(4-methoxyphenyl)ethanone

Crystals, 2011
The crystal and molecular structure of the title compound, viz., (2Z)-2-[3-(4-methoxybenzoyl)-4,4-dimethyl-1,2,-oxazolidin-2-ylidene]-1-(4-methoxyphenyl)ethanone (4), is reported.
Robert A. Gossage, Alan J. Lough, Douglas G. Vaughan, Anna Petrov, Roderick C. Jones   +4 more
doaj   +1 more source

Biochemical Identification of a Nuclear Coactivator Protein Required for AtrR-Dependent Gene Regulation in Aspergillus fumigatus

mSphere, 2022
Azole drugs represent the primary means of treating infections associated with the filamentous fungal pathogen Aspergillus fumigatus. A central player in azole resistance is the Zn2Cys6 zinc cluster-containing transcription factor AtrR.
Sanjoy Paul, Shivani Ror, W. Hayes McDonald, W. Scott Moye-Rowley   +3 more
doaj   +1 more source

Covalent Protein Inhibitors via Tyrosine and Tryptophan Conjugation with Cyclic Imine Mannich Electrophiles

Angewandte Chemie, EarlyView.
Targeted covalent inhibitors (TCI) containing cyclic imine warheads react with tyrosine and tryptophan residues via the Mannich reaction. These cyclic imine warheads show comparable reaction kinetics to cysteine‐reactive electrophiles commonly used in TCIs.
Sijie Wang, Lei Wang, Marco Hadisurya, Siavash Shahbazi Nia, W. Andy Tao, Emily C. Dykhuizen, Casey J. Krusemark   +6 more
wiley   +2 more sources

Screening of the central nervous system in children with invasive pulmonary aspergillosis [PDF]

, 2014
Peer reviewedPublisher ...
Broenen, Emmi, Brüggemann, Roger, Kamphuis-van Ulzen, Karin, Mavinkurve-Groothuis, Annelies, Verweij, Paul, Warris, Adilia   +5 more
core   +2 more sources