Results 41 to 50 of about 56,531 (323)

Synthesis of Novel Thiazole Derivatives Bearing β-Amino Acid and Aromatic Moieties as Promising Scaffolds for the Development of New Antibacterial and Antifungal Candidates Targeting Multidrug-Resistant Pathogens

Molecules, 2021
Rapidly growing antimicrobial resistance among clinically important bacterial and fungal pathogens accounts for high morbidity and mortality worldwide.
Dovilė Malūkaitė, Birutė Grybaitė, Rita Vaickelionienė, Giedrius Vaickelionis, Birutė Sapijanskaitė-Banevič, Povilas Kavaliauskas, Vytautas Mickevičius   +6 more
doaj   +1 more source

Antifungal prophylaxis with azole derivatives [PDF]

Clinical Microbiology and Infection, 2004
In recent years, several reports have underlined the increasing role of fungal infections as a cause of morbidity and mortality in hospitalised patients. For this reason, and also in light of the high mortality rate associated with these infections, chemoprophylaxis has been advocated by several authors.
CASTAGNOLA E, MACHETTI M, BUCCI B, VISCOLI, CLAUDIO   +3 more
openaire   +4 more sources

Cupin‐Type Dimethylsulfoniopropionate Lyase from Pelagibacter ubique (DddKPu) Catalyzes Aza‐Michael Addition of Primary and Secondary Amines to Acrylic Acid

Angewandte Chemie, EarlyView.
A dimethylsulfoniopropionate lyase (DddK) was identified as an efficient aza‐Michaelase for the addition of amines to acrylate. Screening 74 amines with wild‐type DddK and its W26G variant yielded N‐substituted and N,N‐disubstituted β‐amino acids in 30%–93% isolated yield.
Diletta Arceri, Angela Mourelle, Teodor Parella, Jordi Bujons, Carlos J. Moreno, Pere Clapés   +5 more
wiley   +2 more sources

CYP51 Mutations in the Fusarium solani Species Complex: First Clue to Understand the Low Susceptibility to Azoles of the Genus Fusarium

Journal of Fungi, 2022
Members of Fusarium solani species complex (FSSC) are cosmopolitan filamentous fungi responsible for invasive fungal infections in immunocompromised patients.
Pierre Vermeulen, Arnaud Gruez, Anne-Lyse Babin, Jean-Pol Frippiat, Marie Machouart, Anne Debourgogne   +5 more
doaj   +1 more source

Electrochemical ⍺‐C─H Functionalization of Nitramines for Accessing Bifunctional Energetic Heterocycles

Angewandte Chemie, EarlyView.
An electrochemical α‐C─H functionalization of nitramines enables the synthesis of molecules containing bifunctional energetic heterocycles with promising properties. A telescoped, HNO3‐free sequence involving nitration and azolation steps offers a safer, modular, and scalable platform for the synthesis of energetic compounds.
Wan‐Chen Cindy Lee, Luiz F. T. Novaes, Rojan Ali, Thomas Wirth, Song Lin   +4 more
wiley   +2 more sources

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Synthesis and oxidation of some azole-containing thioethers

Beilstein Journal of Organic Chemistry, 2011
Pyrazole and benzotriazole-containing thioethers, namely 1,5-bis(3,5-dimethylpyrazol-1-yl)-3-thiapentane, 1,8-bis(3,5-dimethylpyrazol-1-yl)-3,6-dithiaoctane and 1,3-bis(1,2,3-benzotriazol-1-yl)-2-thiapropane were prepared and fully characterized ...
Andrei S. Potapov, Nina P. Chernova, Vladimir D. Ogorodnikov, Tatiana V. Petrenko, Andrei I. Khlebnikov   +4 more
doaj   +1 more source

Phenotypic Array for Identification and Screening of Antifungals against Aspergillus Isolates from Respiratory Infections in KwaZulu Natal, South Africa

Journal of Fungi, 2023
The rapid emergence of invasive fungal infections correlates with the increasing population of immunocompromised individuals, with many cases leading to death.
Sarla Naicker, Viresh Mohanlall, Sandile Ngubane, John Mellem, Nokuthula Peace Mchunu   +4 more
doaj   +1 more source

Adhesive Properties and Sensitivity to Antifungal Drugs of Candida Albicans, Which Are Released From Patients of Gastroenterological Profile with Candidiasis of the Mucosa of the Upper Part of the Digestive Tract [PDF]

, 2016
Candida albicans were released from 146 loci from 89 patients in order to perform the investigation. The fourth stage of contamination by Candida albicans in the scrape from the tongue and candidiasis of the esophagus or /and the stomach during ...
Kushnirenko, I. (Inessa)
core   +2 more sources

A Novel Environmental Azole Resistance Mutation in Aspergillus fumigatus and a Possible Role of Sexual Reproduction in Its Emergence

mBio, 2017
This study investigated the dynamics of Aspergillus fumigatus azole-resistant phenotypes in two compost heaps with contrasting azole exposures: azole free and azole exposed.
Jianhua Zhang, Eveline Snelders, Bas J. Zwaan, Sijmen E. Schoustra, Jacques F. Meis, Karin van Dijk, Ferry Hagen, Martha T. van der Beek, Greetje A. Kampinga, Jan Zoll, Willem J. G. Melchers, Paul E. Verweij, Alfons J. M. Debets   +12 more
doaj   +1 more source