Results 61 to 70 of about 56,531 (323)

Translation inhibition by rocaglates activates a species-specific cell death program in the emerging fungal pathogen Candida auris [PDF]

, 2020
Fungal infections are a major contributor to infectious disease-related deaths worldwide. Recently, global emergence of the fungal pathogen Candida auris has caused considerable concern because most C.
Brown, Lauren E., Cowen, Leah E., Henkel, Thomas, Iyer, Kali R., Porco, Jr., John A., Robbins, Nicole, Whitesell, Luke   +6 more
core   +1 more source

Scalable Lignin Monomer Production Via Machine Learning‐Guided Reductive Catalytic Fractionation of Lignocellulose

Advanced Science, EarlyView.
This study pioneers an integrated machine learning framework combining large‐scale data modeling, experimental validation, and impact analysis to optimize reductive catalytic fractionation for scalable, sustainable lignin monomer production. Abstract Efficient valorization of lignocellulosic biomass into high‐value lignin monomers is a cornerstone of ...
Meysam Madadi, Ehsan Kargaran, Seyed Sajad Hashemi, Chihe Sun, Joeri F.M. Denayer, Keikhosro Karimi, Fubao Sun, Vijai Kumar Gupta   +7 more
wiley   +1 more source

Exploring hidden dimensions of soil fungal biodiversity: A simple technique to detect soil fungi resistant to antifungal compounds [PDF]

, 2010
Soils are known to be ultimate and complex reservoirs of microbial diversity. The complex dimensions of bacterial and fungal diversity in tropical soils and microbial community dynamics are underexplored.
Nandkumar M. Kamat, Sonashia Velho-Pereira   +1 more
core   +2 more sources

Electrochemical Approach to Organonitrogen Compounds via C–N Coupling

Advanced Science, EarlyView.
This review summarizes recent advances in electrocatalytic C–N coupling for organonitrogen electrosynthesis. It discusses innovative strategies for catalyst design and the electrosynthesis of diverse organonitrogen compounds, including urea, oximes, amino acids, amides, and amines. Additionally, it outlines future opportunities for sustainable C–N bond
Haifei Liu, Wenbo Wei, Qi‐Long Zhu
wiley   +1 more source

Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. [PDF]

, 2019
BACKGROUND: Invasive fungal diseases (IFDs) remain important causes of morbidity and mortality. The consensus definitions of the Infectious Diseases Group of the European Organization for Research and Treatment of Cancer and the Mycoses Study Group have ...
Akan, H, Alexander, BD, Andes, D, Azoulay, E, Baddley, JW, Bassetti, M, Bialek, R, Bradsher, RW, Bretagne, S, Calandra, T, Caliendo, AM, Castagnola, E, Chen, SC, Clancy, CJ, Cruciani, M, Cuenca-Estrella, M, Decker, CF, Desai, SR, Donnelly, JP, Fisher, B, Groll, AH, Harrison, T, Heussel, CP, Jensen, HE, Kauffman, CA, Kibbler, CC, Kontoyiannis, DP, Kullberg, B-J, Lagrou, K, Lamoth, F, Lehrnbecher, T, Lockhart, SR, Loeffler, J, Lortholary, O, Maertens, J, Marchetti, O, Marr, KA, Masur, H, Meis, JF, Morrisey, CO, Nucci, M, Ostrosky-Zeichner, L, Pagano, L, Pappas, PG, Patterson, TF, Perfect, JR, Prokop, CS, Racil, Z, Roilides, E, Ruhnke, M, Shoham, S, Slavin, MA, Sorrell, TC, Steinbach, WJ, Stevens, DA, Thompson, GR, Vazquez, JA, Verweij, PE, Viscoli, C, Walsh, TJ, Warris, A, Wheat, LJ, White, PL, Wingard, JR, Zaoutis, TE   +64 more
core   +5 more sources

Photoinduced Copper‐Catalyzed Cross‐Coupling of Acylsilanes with Heteroarenes via Bimetallic Relay

Advanced Science
The transition metal‐catalyzed direct coupling reactions involving electron‐rich Fischer carbene species are largely underdeveloped and remain a big challenge.
Long Zheng, Ying‐Chao Li, Yichen Wu, Peng Wang   +3 more
doaj   +1 more source

Synergistic Anti-Candida Activity of Bengazole A in the Presence of Bengamide A †. [PDF]

, 2019
Bengazoles A⁻G from the marine sponge Jaspis sp. exhibit potent in vitro antifungal activity against Candida spp. and other pathogenic fungi. The mechanism of action (MOA) of bengazole A was explored in Candida albicans under both liquid culture and ...
Cheng, Tina, Jamison, Matthew T, Molinski, Tadeusz F, Wang, Xiao   +3 more
core  

History of the development of azole derivatives [PDF]

Clinical Microbiology and Infection, 2004
Until the 1940s, relatively few agents were available for the treatment of systemic fungal infections. The development of the polyene antifungals represented a major advance in medical mycology. Although amphotericin B quickly became the mainstay of therapy for serious infections, its use was associated with infusion-related side-effects and dose ...
openaire   +3 more sources

Heat shock protein 90 (Hsp90) as a molecular target for the development of novel drugs against the dermatophyte Trichophyton rubrum

Frontiers in Microbiology, 2015
Treatment of fungal infections is difficult due to several reasons, such as side effects of drugs, emergence of resistant strains, and limited number of molecular targets for the drug compounds. In fungi, heat shock proteins (HSP) have been implicated in
Tiago R. Jacob, Nalu T. A. ePeres, Maíra P. Martins, Elza A. S. Lang, Pablo R. Sanches, Antonio eRossi, Nilce Maria eMartinez-Rossi   +6 more
doaj   +1 more source

Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium

Antibiotics, 2020
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs), along with significant agricultural crop loss caused by various fungal species, has resulted in the widespread use of antifungal agents.
Amir Arastehfar, Toni Gabaldón, Rocio Garcia-Rubio, Jeffrey D. Jenks, Martin Hoenigl, Helmut J. F. Salzer, Macit Ilkit, Cornelia Lass-Flörl, David S. Perlin   +8 more
doaj   +1 more source