Molecular Detection of Azole-Resistant Aspergillus fumigatus in Clinical Samples
Frontiers in Microbiology, 2018 Aspergillus diseases are often caused by Aspergillus fumigatus. Azoles are the mainstay of therapy, but the management of aspergillosis is hampered by the emergence of azole resistance.
Jochem B. Buil +7 more
doaj +1 more source
Exploring hidden dimensions of soil fungal biodiversity: A simple technique to detect soil fungi resistant to antifungal compounds [PDF]
, 2010 Soils are known to be ultimate and complex reservoirs of microbial diversity. The complex dimensions of bacterial and fungal diversity in tropical soils and microbial community dynamics are underexplored.
Nandkumar M. Kamat +1 more
core +2 more sources
4-Amino-substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases
Molecules, 2014 A series of N-aryl-β-alanine derivatives and diazobenzenesulfonamides containing aliphatic rings were designed, synthesized, and their binding to carbonic anhydrases (CA) I, II, VI, VII, XII, and XIII was studied by the fluorescent thermal shift assay ...
Kęstutis Rutkauskas +12 more
doaj +1 more source
Molecules, 2021 Invasive aspergillosis, mainly caused by Aspergillus fumigatus, can lead to severe clinical outcomes in immunocompromised individuals. Antifungal treatment, based on the use of azoles, is crucial to increase survival rates.
Irene Gonzalez-Jimenez +4 more
doaj +1 more source
The zinc cluster proteins Upc2 and Ecm22 promote filamentation in Saccharomyces cerevisiae by sterol biosynthesis-dependent and -independent pathways. [PDF]
, 2015 The transition between a unicellular yeast form to multicellular filaments is crucial for budding yeast foraging and the pathogenesis of many fungal pathogens such as Candida albicans.
Höfken, T, Woods, K
core +1 more source
Frontiers in Microbiology, 2015 Treatment of fungal infections is difficult due to several reasons, such as side effects of drugs, emergence of resistant strains, and limited number of molecular targets for the drug compounds. In fungi, heat shock proteins (HSP) have been implicated in
Tiago R. Jacob +6 more
doaj +1 more source
Synergistic Anti-Candida Activity of Bengazole A in the Presence of Bengamide A †. [PDF]
, 2019 Bengazoles A⁻G from the marine sponge Jaspis sp. exhibit potent in vitro antifungal activity against Candida spp. and other pathogenic fungi. The mechanism of action (MOA) of bengazole A was explored in Candida albicans under both liquid culture and ...
Cheng, Tina +3 more
core
Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium
Antibiotics, 2020 The high clinical mortality and economic burden posed by invasive fungal infections (IFIs), along with significant agricultural crop loss caused by various fungal species, has resulted in the widespread use of antifungal agents.
Amir Arastehfar +8 more
doaj +1 more source
Creation and assessment of a clinical predictive calculator and mortality associated with Candida krusei bloodstream infections [PDF]
, 2018 Background Candida krusei bloodstream infection (CK BSI) is associated with high mortality, but whether this is due to underlying comorbidities in affected patients or the organism itself is unknown.
Hsueh, Kevin +4 more
core +2 more sources
Chemistry – A European Journal, EarlyView.Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley +1 more source