Results 61 to 70 of about 72,034 (334)

Phenotypic Array for Identification and Screening of Antifungals against Aspergillus Isolates from Respiratory Infections in KwaZulu Natal, South Africa

Journal of Fungi, 2023
The rapid emergence of invasive fungal infections correlates with the increasing population of immunocompromised individuals, with many cases leading to death.
Sarla Naicker, Viresh Mohanlall, Sandile Ngubane, John Mellem, Nokuthula Peace Mchunu   +4 more
doaj   +1 more source

ABC transporters and azole susceptibility in laboratory strains of the wheat pathogen Mycosphearella graminicola [PDF]

Laboratory strains of Mycosphaerella graminicola with decreased susceptibilities to the azole antifungal agent cyproconazole showed a multidrug resistance phenotype by exhibiting cross-resistance to an unrelated chemical, cycloheximide or rhodamine 6G ...
Nistelrooy, J.G.M., Van, Stergiopoulos, I., Waard, M.A., De, Zwiers, L.H.   +3 more
core   +2 more sources

Synthesis and oxidation of some azole-containing thioethers

Beilstein Journal of Organic Chemistry, 2011
Pyrazole and benzotriazole-containing thioethers, namely 1,5-bis(3,5-dimethylpyrazol-1-yl)-3-thiapentane, 1,8-bis(3,5-dimethylpyrazol-1-yl)-3,6-dithiaoctane and 1,3-bis(1,2,3-benzotriazol-1-yl)-2-thiapropane were prepared and fully characterized ...
Andrei S. Potapov, Nina P. Chernova, Vladimir D. Ogorodnikov, Tatiana V. Petrenko, Andrei I. Khlebnikov   +4 more
doaj   +1 more source

CYP51 Mutations in the Fusarium solani Species Complex: First Clue to Understand the Low Susceptibility to Azoles of the Genus Fusarium

Journal of Fungi, 2022
Members of Fusarium solani species complex (FSSC) are cosmopolitan filamentous fungi responsible for invasive fungal infections in immunocompromised patients.
Pierre Vermeulen, Arnaud Gruez, Anne-Lyse Babin, Jean-Pol Frippiat, Marie Machouart, Anne Debourgogne   +5 more
doaj   +1 more source

An aptamer-biosensor for azole class antifungal drugs [PDF]

, 2017
This report describes the development of an aptamer for sensing azole antifungal drugs for therapeutic drug monitoring. Modified Synthetic Evolution of Ligands through Exponential Enrichment (SELEX) was used to discover a DNA aptamer recognizing azole class antifungal drugs.
arxiv   +1 more source

Environmental Hotspots for Azole Resistance Selection of Aspergillus fumigatus, the Netherlands

Emerging Infectious Diseases, 2019
Azole resistance is a major concern for treatment of infections with Aspergillus fumigatus. Environmental resistance selection is a main route for Aspergillus spp. to acquire azole resistance.
Sijmen E. Schoustra, A. Debets, A. Rijs, Jianhua Zhang, E. Snelders, P. Leendertse, W. Melchers, A. Rietveld, B. Zwaan, P. Verweij   +9 more
semanticscholar   +1 more source

Screening of the central nervous system in children with invasive pulmonary aspergillosis [PDF]

, 2014
Peer reviewedPublisher ...
Broenen, Emmi, Brüggemann, Roger, Kamphuis-van Ulzen, Karin, Mavinkurve-Groothuis, Annelies, Verweij, Paul, Warris, Adilia   +5 more
core   +2 more sources

Synthesis of Novel Thiazole Derivatives Bearing β-Amino Acid and Aromatic Moieties as Promising Scaffolds for the Development of New Antibacterial and Antifungal Candidates Targeting Multidrug-Resistant Pathogens

Molecules, 2021
Rapidly growing antimicrobial resistance among clinically important bacterial and fungal pathogens accounts for high morbidity and mortality worldwide.
Dovilė Malūkaitė, Birutė Grybaitė, Rita Vaickelionienė, Giedrius Vaickelionis, Birutė Sapijanskaitė-Banevič, Povilas Kavaliauskas, Vytautas Mickevičius   +6 more
doaj   +1 more source

Transcriptome assembly and profiling of Candida auris reveals novel insights into biofilm-mediated resistance [PDF]

, 2018
Candida auris has emerged as a significant global nosocomial pathogen. This is primarily due to its antifungal resistance profile but also its capacity to form adherent biofilm communities on a range of clinically important substrates.
Ben-Ami, Berkow, Berkow, Bizerra, Bongomin, Borman, Borman, Calvo, Chatterjee, Chowdhary, Defosse, Denning, Dominguez, Fisher, Fonseca, Fox, Fu, Grahl, Haas, Hager, Hashemi, Hunter, Jeffery-Smith, Kean, Kean, Kean, Kean, Kempf, Kordalewska, Kordalewska, Larkin, Liu, Liu, Lockhart, Lohse, Martínez, Mukherjee, Naglik, Naglik, Nailis, Nobile, Perfect, Pierce, Rajendran, Rajendran, Rajendran, Ramage, Ramage, Ramage, Rodrigues, Ruiz-Gaitán, Schelenz, Sherry, Sherry, Silva, Soldini, Taff, Taff, Tumbarello, Tunney, Winter, Zarnowski, Zhao, Zhao   +63 more
core   +3 more sources

Pharmacokinetic drug interactions of azoles [PDF]

Current Fungal Infection Reports, 2008
Drug-drug interactions are a major concern with triazoles. Azoles are potent metabolic inhibitors and interactions commonly occur via metabolizing enzymes (ie, cytochrome P450 isoenzyme superfamily) or drug transporters (ie, P-glycoprotein). However, the clinical relevance of these interactions may vary upon the azole involved and upon the “target ...
Bruggemann, R.J.M., Alffenaar, J.W.C., Blijlevens, N.M.A., Billaud, E.M., Kosterink, J.G.W., Verweij, P.E., Burger, D.M.   +6 more
openaire   +4 more sources