Translation inhibition by rocaglates activates a species-specific cell death program in the emerging fungal pathogen Candida auris [PDF]
, 2020 Fungal infections are a major contributor to infectious disease-related deaths worldwide. Recently, global emergence of the fungal pathogen Candida auris has caused considerable concern because most C.
Brown, Lauren E. +6 more
core +1 more source
Pesticide Contamination in the Hair of Children From Colonia San Juan, a Rural Community in Paraguay
Drug Testing and Analysis, EarlyView.Hair analysis in children from a rural community in Paraguay reveals exposure to organophosphates, pyrethroids, neonicotinoids, fungicides, herbicides, and endocrine disruptors, highlighting the urgent need for stricter environmental protections and preventive health measures. ABSTRACT Chronic exposure to pesticides can cause carcinogenic, reproductive,
Stela Benitez Leite +5 more
wiley +1 more source
ABC transporters and azole susceptibility in laboratory strains of the wheat pathogen Mycosphearella graminicola [PDF]
Laboratory strains of Mycosphaerella graminicola with decreased susceptibilities to the azole antifungal agent cyproconazole showed a multidrug resistance phenotype by exhibiting cross-resistance to an unrelated chemical, cycloheximide or rhodamine 6G ...
Nistelrooy, J.G.M., Van +3 more
core +2 more sources
Fungal biofilm resistance [PDF]
, 2012 Fungal biofilm infections have become increasingly recognised as a significant clinical problem. One of the major reasons behind this is the impact that these have upon treatment, as antifungal therapy often fails and surgical intervention is required ...
Rajendran, Ranjith +3 more
core +4 more sources
Study of Different Chiral Columns for the Enantiomeric Separation of Azoles Using Supercritical Fluid Chromatography [PDF]
, 2022 Laura Toribio +5 more
openalex +1 more source
ChemistryOpen, EarlyView.It has been found that quinic acid, an organic acid found in various plants, exhibits a high level of corrosion inhibition activity in preventing HCl‐induced corrosion and maintains its stability up to 144 h. Environmentally friendly quinic acid has a high potential for use as corrosion inhibitors in mild steel.
Serap Toprak Döşlü, Leyla ERCAN
wiley +1 more source
Photoinduced Copper‐Catalyzed Cross‐Coupling of Acylsilanes with Heteroarenes via Bimetallic Relay
Advanced ScienceThe transition metal‐catalyzed direct coupling reactions involving electron‐rich Fischer carbene species are largely underdeveloped and remain a big challenge.
Long Zheng +3 more
doaj +1 more source
ChemistryOpen, EarlyView.New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha +6 more
wiley +1 more source
The Hsp90 co-chaperones Sti1, Aha1, and P23 regulate adaptive responses to antifungal azoles
Frontiers in Microbiology, 2016 Heat Shock Protein 90 (Hsp90) is essential for tumor progression in humans and drug resistance in fungi. However, the roles of its many co-chaperones in antifungal resistance are unknown. In this study, by susceptibility test of Neurospora crassa mutants
Xiaokui Gu +5 more
doaj +1 more source
Mitochondrial Complex I Is a Global Regulator of Secondary Metabolism, Virulence and Azole Sensitivity in Fungi. [PDF]
PLoS ONE, 2016 Recent estimates of the global burden of fungal disease suggest that that their incidence has been drastically underestimated and that mortality may rival that of malaria or tuberculosis.
Mike Bromley +11 more
doaj +1 more source