Results 81 to 90 of about 56,531 (323)

Shedding Light on Synthetic Autocatalysis: From Conventional Closed‐Shell Chemistries to Overlooked Open‐Shell Occurrences

Chemistry – A European Journal, EarlyView.
Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley   +1 more source

Repurposing of terconazole as an anti Trypanosoma cruzi agent [PDF]

, 2019
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. Currently there are no effective treatments for the chronic phase of the disease, when most patients are diagnosed, therefore the development of ...
Martínez Sayé, Melisa Soledad, Miranda, Mariana Reneé, Pereira, Claudio Alejandro, Reigada, Chantal, Valera Vera, Edward Augusto   +4 more
core   +1 more source

Role of isavuconazole in the treatment of invasive fungal infections

Therapeutics and Clinical Risk Management, 2016
Dustin T Wilson,1,2 V Paul Dimondi,1,3 Steven W Johnson,1,4 Travis M Jones,1 Richard H Drew1,5 1Department of Pharmacy Practice, Campbell University College of Pharmacy & Health Sciences, Buies Creek, NC, USA; 2Department of Pharmacy, Duke ...
Wilson DT, Dimondi VP, Johnson SW, Jones TM, Drew RH   +4 more
doaj  

Unexpected effects of azole transporter inhibitors on antifungal susceptibility in Candida glabrata and other pathogenic Candida species. [PDF]

PLoS ONE, 2017
The pathogenic fungus Candida glabrata is often resistant to azole antifungal agents. Drug efflux through azole transporters, such as Cdr1 and Cdr2, is a key mechanism of azole resistance and these genes are under the control of the transcription factor ...
Yohsuke Nagayoshi, Taiga Miyazaki, Shintaro Shimamura, Hironobu Nakayama, Asuka Minematsu, Shunsuke Yamauchi, Takahiro Takazono, Shigeki Nakamura, Katsunori Yanagihara, Shigeru Kohno, Hiroshi Mukae, Koichi Izumikawa   +11 more
doaj   +1 more source

Supramolecular 3D Polymers Created via Chalcogen Bonding Using Benzotellurazoles as Planar Recognition Units

Chemistry – A European Journal, EarlyView.
Starting with small planar benzotellurazoles, it is possible to create 3D supramolecular architectures. These exhibit a high degree of cross‐linking, which is caused by various chalcogen bonding (ChB) motifs. Introducing electron‐withdrawing substituents onto the benzotellurazole makes the ChB motifs more apparent and results in more complex ...
Jan Schulte, Saber Mehrparvar, Paul Kamminga, Christoph Wölper, Gebhard Haberhauer   +4 more
wiley   +1 more source

Cycloaddition and Annulation Reactions with Donor‐Acceptor Cyclobutanes

Helvetica Chimica Acta, EarlyView.
Reviewing the rise of donor‐acceptor cyclobutanes in (4 + 2) annulations, from Lewis/Brønsted acid to electrocatalysis, enabling stereoselective access to complex heterocycles and natural products. Abstract Donor‐acceptor (DA) cyclobutanes are emerging as valuable synthetic intermediates due to their ring strain and polarized C─C bonds, which allow for
Emma G. L. Robert, Jerome Waser
wiley   +1 more source

Prevalence of QoI resistance and mtDNA diversity in the Irish Zymoseptoria tritici population [PDF]

, 2019
peer-reviewedThe emergence and spread of Quinone outside Inhibitor (QoI) fungicide resistance in the Irish Zymoseptoria tritici population in the early 2000s had immediate impacts on the efficacy of the entire group of fungicides for the control of ...
Bucar, D.E., Hutton, F., Kildea, Steven, Phelan, S., Rosa, S. de la, Welch, T.E.   +5 more
core   +1 more source

Distribution and Antimicrobial Resistance of Pathogenic Bacteria in Patients With Sternal Osteomyelitis

iLABMED, EarlyView.
This study conducted a retrospective analysis of microbiological culture results and antimicrobial resistance patterns in patients with sternal osteomyelitis at a tertiary medical center. The primary pathogens causing sternal osteomyelitis were gram‐positive bacteria. Infections with multidrug‐resistant organisms were also relatively common among these
Yumin Yang, Manhui Zhang, Yue Pan, Lihua Qi, Zhigang Wang, Xian Xia   +5 more
wiley   +1 more source

4-Amino-substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases

Molecules, 2014
A series of N-aryl-β-alanine derivatives and diazobenzenesulfonamides containing aliphatic rings were designed, synthesized, and their binding to carbonic anhydrases (CA) I, II, VI, VII, XII, and XIII was studied by the fluorescent thermal shift assay ...
Kęstutis Rutkauskas, Asta Zubrienė, Ingrida Tumosienė, Kristina Kantminienė, Marytė Kažemėkaitė, Alexey Smirnov, Justina Kazokaitė, Vaida Morkūnaitė, Edita Čapkauskaitė, Elena Manakova, Saulius Gražulis, Zigmuntas J. Beresnevičius, Daumantas Matulis   +12 more
doaj   +1 more source

Oxidative phosphorylation at the crossroads of cancer: Metabolic orchestration, stromal collusion, and emerging therapeutic horizons

Interdisciplinary Medicine, EarlyView.
Although most cancer cells rely on aerobic glycolysis, Oxidative phosphorylation (OXPHOS) remains essential for their survival, proliferation, and metastasis. With the emergence of OXPHOS‐targeted drugs, its therapeutic potential is becoming increasingly evident.
Keke Chen, Bo Wang, Hongying Shu, Jianxin Lyu, Wei Cui, Hezhi Fang   +5 more
wiley   +1 more source