Results 151 to 160 of about 29,974 (187)

Azole-Resistant Invasive Aspergillosis: Relationship to Agriculture

Current Fungal Infection Reports, 2012
Azole resistance in Aspergillus fumigatus has been increasingly reported particularly over the last decade. Two routes of acquisition are described: selection of resistance during long term azole therapy in the clinical setting, and primary acquisition of resistant isolates from the environment due to the considerable use of azole fungicides in ...
Stensvold, Christen Rune, Jørgensen, Lise Nistrup, Arendrup, Maiken Cavling   +2 more
openaire   +1 more source

Azole resistance mechanisms in pathogenic M. furfur.

Antimicrobial agents and chemotherapy, 2021
Malassezia are emerging fungal pathogens causing opportunistic skin and severe systemic infection. Nosocomial outbreaks are associated with azole resistance and understanding of the underlying mechanisms are limited to knowledge from other fungal species. Herein, we identified distinct antifungal susceptibility patterns in 26 Malassezia furfur isolates
Leong, Cheryl, Kit, Joel Chan Wai, Lee, Shi Mun, Lam, Yuen In, Goh, Joleen P Z, Ianiri, Giuseppe, Dawson, Thomas L   +6 more
openaire   +2 more sources

Fungal Drug Resistance: Azoles

2009
Azole antifungal agents are widely used in the clinical arena to treat a variety of fungal infections. The azoles inhibit fungal lanosterol demethylase, a key fungal enzyme in the ergosterol biosynthetic pathway, leading to an altered membrane physiology and, most frequently, a fungistatic effect.
Jose L. Lopez-Ribot, Thomas F. Patterson
openaire   +1 more source

Azole Resistance in Dermatophytes

Journal of the American Podiatric Medical Association, 2016
Azole antifungal agents (eg, fluconazole and itraconazole) have been widely used to treat superficial fungal infections caused by dermatophytes and, unlike the allylamines (such as terbinafine and naftifine), have been associated with resistance development.
openaire   +1 more source

Molecular basis of resistance to azole antifungals

Trends in Molecular Medicine, 2002
The increased incidence of invasive mycoses and the emerging problem of antifungal drug resistance has prompted investigations of the underlying molecular mechanisms, particularly for the azole compounds central to current therapy. The target site for the azoles is the ERG11 gene product, the cytochrome P450 lanosterol 14alpha-demethylase, which is ...
LUPETTI, ANTONELLA, DANESI, ROMANO, CAMPA, MARIO, M. Del Tacca, S. Kelly   +4 more
openaire   +2 more sources

An azole-resistant isolate of Malassezia pachydermatis

Veterinary Microbiology, 2011
Canine Malassezia dermatitis (MD) is frequently treated with systemic ketoconazole (KTZ) and itaconazole (ITZ). However, the antifungal susceptibility of clinical isolates of M. pachydermatis from dogs and cats to the azoles has not been well investigated.
Misako, Nijima, Rui, Kano, Masahiko, Nagata, Atsuhiko, Hasegawa, Hiroshi, Kamata   +4 more
openaire   +2 more sources

Molecular Detection of Resistance to Azole Components

2016
Fungal infections have increased significantly in the last few years, and their outcomes are in part complicated by the emergence of antifungal drug-resistant pathogens. Together with Candida species, the mould Aspergillus fumigatus is one of the most prevalent organisms to cause invasive fungal disease. The molecular detection of (tri)azole resistance
Posteraro, Brunella, Vella, Antonietta, De Carolis, Elena, Sanguinetti, Maurizio   +3 more
openaire   +2 more sources

Azole resistant Aspergillus fumigatus: An emerging problem

Médecine et Maladies Infectieuses, 2013
Azole resistance has appeared recently in Aspergillus fumigatus and increased dangerously in the last decade. The main resistance mechanism is a point mutation of CYP51A, the gene encoding 14α-sterol demethylase, the target enzyme of azole antifungal drugs. This mutation can induce resistance to itraconazole alone or multi-azole resistance.
L, Lelièvre, M, Groh, C, Angebault, A-C, Maherault, E, Didier, M-E, Bougnoux   +5 more
openaire   +2 more sources

Antifungal drug resistance to azoles and polyenes

The Lancet Infectious Diseases, 2002
There is an increased awareness of the morbidity and mortality associated with fungal infections caused by resistant fungi in various groups of patients. Epidemiological studies have identified risk factors associated with antifungal drug resistance.
Mar, Masiá Canuto, Félix, Gutiérrez Rodero   +1 more
openaire   +2 more sources

Azole resistance in Aspergillus fumigatus

Current Opinion in Infectious Diseases, 2013
Reports from the end of the 2000s forced the medical community to take azole resistance in Aspergillus fumigatus into account. Not only patients with chronic aspergillus disease, who develop resistance during long-term azole treatment, but also azole-naive patients are at risk, owing to the presence of resistant strains in the environment.
Vermeulen, E., Lagrou, K., Verweij, P.E.
openaire   +3 more sources