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Asymmetric 1,3-dipolar cycloadditions of acrylamides [PDF]

open access: yes, 2009
This critical review, which is relevant to researchers in synthetic organic chemistry, focuses on asymmetric 1,3-dipolar cycloadditions with acrylamides.
Kissane, Marie, Maguire, Anita R.
core   +1 more source

Synthesis of Spirocyclic Amines by 1,3-Dipolar Cycloaddition of Azomethine Ylides and Azomethine Imines [PDF]

open access: yesSynthesis, 2020
Simple ketone starting materials with a halide leaving group and an alkene were prepared in one step and heated with glycine or glycine esters to promote a tandem imine formation, cyclization, and dipolar cycloaddition cascade. The chemistry was also feasible with acetylhydrazide.
Choi, A.   +3 more
openaire   +2 more sources

A Diastereoselective Synthesis of Dispiro[oxindole-cyclohexanone]pyrrolidines by 1,3-Dipolar Cycloaddition

open access: yesMolecules, 2017
For the first time, arylmethylidene cyclohexanones that are non-symmetrical due to the presence of peripheral substituents were studied in 1,3-dipolar cycloaddition reactions.
Alexander Anis’kov   +3 more
doaj   +1 more source

Synthesis and Biological Evaluation of S-, O- and Se-Containing Dispirooxindoles

open access: yesMolecules, 2021
A series of novel S-, O- and Se-containing dispirooxindole derivatives has been synthesized using 1,3-dipolar cycloaddition reaction of azomethine ylide generated from isatines and sarcosine at the double C=C bond of 5-indolidene-2-chalcogen-imidazolones
Maksim Kukushkin   +10 more
doaj   +1 more source

Domino 1,3-Dipolar Cycloadditions of N-Alkyl-α-Amino Esters with Paraformaldehyde: A Direct Access to α-Hydroxymethyl α-Amino Acids [PDF]

open access: yes, 2014
N-Alkyl-α-amino esters undergo a domino reaction, based on the iminium cation generation, with paraformaldehyde, followed by a 1,3-dipolar cycloaddition of the stabilized azometh­ine ylide with another equivalent of formaldehyde.
Castelló Moncayo, Luis Miguel   +2 more
core   +2 more sources

Covalent Functionalisation of rGO and Nanodiamonds: Complementary Versatility and Applicability of Azomethine Ylide, Nitrile Oxide and Nitrone [PDF]

open access: yesChemPlusChem, Volume 90, Issue 3, March 2025.
1,3‐DCA of nitrone and nitrile oxide to carbon based nanomaterial has been adapted from rGO to yield more stable, unique and biocompatible NDs. This strategy provides an economical, rapid, and efficient method for the production of pure, hydrophilic carbon nanomaterials, which are suitable for a wide range of applications.
Barge, Alessandro   +9 more
core   +2 more sources

Synthesis and Characterization of New Spirooxindoles Including Triazole and Benzimidazole Pharmacophores via [3+2] Cycloaddition Reaction: An MEDT Study of the Mechanism and Selectivity

open access: yesMolecules, 2023
A new series of spirooxindoles based on benzimidazole, triazole, and isatin moieties were synthesized via a [3+2] cycloaddition reaction protocol in one step. The single X-ray crystal structure of the intermediate triazole-benzimidazole 4 was solved. The
Saeed Alshahrani   +7 more
doaj   +1 more source

Stereoselective synthesis of fused tetrahydroquinazolines through one-pot double [3 + 2] dipolar cycloadditions followed by [5 + 1] annulation

open access: yesBeilstein Journal of Organic Chemistry, 2016
The one-pot [3 + 2] cycloaddition of an azomethine ylide with a maleimide followed by another [3 + 2] cycloaddition of an azide with the second maleimide gives a 1,5-diamino intermediate which is used for a sequential aminomethylation reaction with ...
Xiaofeng Zhang   +6 more
doaj   +1 more source

Coinage Metal Complexes as Chiral Catalysts for 1,3-Dipolar Cycloadditions [PDF]

open access: yes, 2014
In this account, we describe the experience of our research group in the implementation of chiral coinage metal complexes into the efficient enantioselective 1,3-DC of azomethine ylides derived from α-amino acids and azlactones with different ...
Nájera, Carmen, Sansano, Jose M.
core   +2 more sources

Enantiomerically Enriched Aziridine‐2‐carboxylates via Copper‐Catalyzed Reductive Kinetic Resolution of 2H‐Azirines

open access: yesAngewandte Chemie, Volume 137, Issue 26, June 24, 2025.
Kinetic resolution by copper hydride catalyzed reduction of 2H‐azirines secured optically enriched N‐H aziridine‐2‐carboxylates with excellent diastereoselectivity (>20:1) and good enantioselectivity (up to 94% ee). DFT calculations and non‐covalent interaction analysis established the reaction pathway and revealed two key non‐covalent interactions ...
Yinuo Zheng   +3 more
wiley   +2 more sources

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