Results 61 to 70 of about 30,808 (260)

General Approach toward Aspidospermatan-Type Alkaloids Using One-Pot Vilsmeier-Haack Cyclization and Azomethine Ylide Cycloaddition.

Journal of Organic Chemistry, 2017
The development of a new one-pot reaction sequence afforded the tricyclic core of several aspidospermatan-type alkaloids from a linear, densely functionalized substrate.
Clémence Hauduc, G. Bélanger
semanticscholar   +1 more source

Synthesis of fused tricyclic amines unsubstituted at the ring-junction positions by a cascade condensation, cyclization, cycloaddition then decarbonylation strategy

Beilstein Journal of Organic Chemistry, 2012
Heating aldehydes that contain a protected hydroxymethyl group, a tethered alkyl chloride and a tethered alkenyl group at the α-position of the aldehyde with an amine sets up a cascade (tandem) reaction sequence involving condensation to an intermediate ...
Iain Coldham, Adam J. M. Burrell, Hélène D. S. Guerrand, Luke Watson, Nathaniel G. Martin, Niall Oram   +5 more
doaj   +1 more source

A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction

Molecules, 2013
An efficient synthesis of novel dispirooxindoles has been achieved through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5 ...
Liang Ouyang, Rongsheng Tong, Jianyou Shi, Zhixiang Yuan, Guang Ouyang, Jun He   +5 more
doaj   +1 more source

Studies toward Total Synthesis of (±)-Caldaphnidine C via One-Pot Sequential Intramolecular Vilsmeier-Haack and Azomethine Ylide 1,3-Dipolar Cycloaddition.

Journal of Organic Chemistry, 2016
An application of a one-pot sequential Vilsmeier-Haack cyclization and intramolecular azomethine ylide 1,3-dipolar cycloaddition toward the total synthesis of (±)-caldaphnidine C is presented.
Jonathan Boudreault, F. Lévesque, G. Bélanger   +2 more
semanticscholar   +1 more source

[3 + 2] Cycloaddition with photogenerated azomethine ylides in β-cyclodextrin [PDF]

Beilstein Journal of Organic Chemistry, 2020
Stability constants for the inclusion complexes of cyclohexylphthalimide 2 and adamantylphthalimide 3 with β-cyclodextrin (β-CD) were determined by 1H NMR titration, K = 190 ± 50 M−1, and K = 2600 ± 600 M−1, respectively. Photochemical reactivity of the inclusion complexes 2@β-CD and 3@β-CD was investigated, and we found out that β-CD does not affect ...
Margareta Sohora, Leo Mandić, Nikola Basarić   +2 more
openaire   +5 more sources

Enantiomerically Enriched Aziridine‐2‐carboxylates via Copper‐Catalyzed Reductive Kinetic Resolution of 2H‐Azirines

Angewandte Chemie, Volume 137, Issue 26, June 24, 2025.
Kinetic resolution by copper hydride catalyzed reduction of 2H‐azirines secured optically enriched N‐H aziridine‐2‐carboxylates with excellent diastereoselectivity (>20:1) and good enantioselectivity (up to 94% ee). DFT calculations and non‐covalent interaction analysis established the reaction pathway and revealed two key non‐covalent interactions ...
Yinuo Zheng, Elvis Wang Hei Ng, Antonio Rizzo, Pauline Chiu   +3 more
wiley   +2 more sources

Multicomponent synthesis, biological evaluation and molecular docking of new spiro-oxindole derivatives

Journal of Taibah University for Science, 2017
A new series of spiro-oxindoles that were identified based upon their ability to inhibit methionine tRNA synthase (PDB ID: 1PFV) and glucosamine-6-phosphate synthase (PDB ID: 1JXA) enzymes in virtual screening was synthesized by a three-component 1,3 ...
M. Sapnakumari, B. Narayana, K.S. Shashidhara, B.K. Sarojini   +3 more
doaj   +1 more source

Domino Multicomponent Approach for the Synthesis of Functionalized Spiro-Indeno[1,2-b]quinoxaline Heterocyclic Hybrids and Their Antimicrobial Activity, Synergistic Effect and Molecular Docking Simulation

Molecules, 2019
An expedient synthesis of hitherto unexplored novel hybrid heterocycles comprising dispiropyrrolidine, N-styrylpiperidone and indeno[1,2-b]quinoxaline units has been developed via domino multicomponent 1,3-dipolar cycloaddition strategy employing a new ...
Abdulrahman I. Almansour, Natarajan Arumugam, Raju Suresh Kumar, Dhaifallah M. Al-thamili, Govindasami Periyasami, Karuppiah Ponmurugan, Naif Abdullah Al-Dhabi, Karthikeyan Perumal, Dhanaraj Premnath   +8 more
doaj   +1 more source

A Molecular Electron Density Theory Study of the [3+2] Cycloaddition Reaction of Pseudo(mono)radical Azomethine Ylides with Phenyl Vinyl Sulphone

Organics, 2022
The [3+2] cycloaddition (32CA) reaction of an azomethine ylide (AY), derived from isatin and L-proline, with phenyl vinyl sulphone has been studied within Molecular Electron Density Theory (MEDT) at the ωB97X-D/6-311G(d,p) level. ELF topological analysis
Mar Ríos-Gutiérrez, Assem Barakat, Luis R. Domingo   +2 more
doaj   +1 more source

Inverse‐Electron‐Demand Diels–Alder Reaction of Tropone with Graphene Supported on Cu(111)

Small, EarlyView.
The inverse‐electron‐demand Diels–Alder reaction between tropone and graphene supported on Cu(111), catalyzed by B(C6F5)3 or BPh3, gave [4 + 2] and [8 + 2] cycloadducts, respectively. Computations reveal that the cycloadditions become favorable on curved graphene with secondary substrate charge transfer effects and reveal the origins of the product ...
Jia Tu, Wentong Zhou, Lawrence M. Wolf, Mingdi Yan   +3 more
wiley   +1 more source