Results 1 to 10 of about 15,583 (213)
ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice [PDF]
Toxins, 2017 There is a geographic inequality in the incidence of colorectal cancer, lowest in developing countries, and greatest in developed countries.
Peng Li +3 more
doaj +3 more sources
Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer. [PDF]
PLoS ONE, 2013 Ptp4a3 (commonly known as PRL-3) is an enigmatic member of the Ptp4a family of prenylated protein tyrosine phosphatases that are highly expressed in many human cancers.
Mark W Zimmerman +2 more
doaj +7 more sources
Cardamonin Attenuates Experimental Colitis and Associated Colorectal Cancer
Biomolecules, 2021 Cardamonin is a naturally occurring chalcone, majorly from the Zingiberaceae family, which includes a wide range of spices from India. Herein, we investigated the anti-inflammatory property of cardamonin using different in vitro and in vivo systems.
Shirley James +11 more
doaj +1 more source
Current Issues in Molecular Biology, 2022 A polyphenolic component of ginger, 6-gingerol, is widely reported to possess antioxidant, anti-inflammatory and anticancer activities. In the current study, it was aimed to investigate the anticancer effects of 6-gingerol (6-Gin) on azoxymethane (AOM ...
Abdulaziz A. Aloliqi
doaj +1 more source
Metabolites, 2021 Consumption of a high-fat diet (HFD) links obesity to colon cancer in humans. Our data show that a HFD (45% energy fat versus 16% energy fat in an AIN-93 diet (AIN)) promotes azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) formation in a ...
Huawei Zeng +3 more
doaj +1 more source
Dietary phytate lowers K-ras mutational frequency, decreases DNA-adduct and hydroxyl radical formation in azoxymethane-induced colon cancer [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Dietary phytate is known to protect against azoxymethane (AOM)-induced preneoplastic lesions. The present study was designed to determine whether dietary phytate affects mutation frequency in colon epithelial cells challenged with ...
Poorna Venkata Satya Prasad Pallem +2 more
doaj +1 more source
Epigenetics, 2021 Because ADAM17 promotes colonic tumorigenesis, we investigated potential miRNAs regulating ADAM17; and examined effects of diet and tumorigenesis on these miRNAs.
Urszula Dougherty +24 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Irritable bowel disease (IBD), which results in an elevated risk of colitis-associated colorectal cancer (CAC), is characterized by inflammation and barrier disruption of the gut.
Hee-Young Kim +7 more
doaj +1 more source
Mouse models of colorectal cancer. [PDF]
, 2011 Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models.
Koeffler, H Phillip +2 more
core +2 more sources
Manipulation of the Gut Microbiota Reveals Role in Colon Tumorigenesis
mSphere, 2016 There is growing evidence that individuals with colonic adenomas and carcinomas harbor a distinct microbiota. Alterations to the gut microbiota may allow the outgrowth of bacterial populations that induce genomic mutations or exacerbate tumor-promoting ...
Joseph P. Zackular +3 more
doaj +1 more source