Results 11 to 20 of about 21,150 (298)

Pinostrobin attenuates azoxymethane-induced colorectal cytotoxicity in rats through augmentation of apoptotic Bax/Bcl-2 proteins and antioxidants

SAGE Open Medicine, 2023
Objectives: Pinostrobin (5-hydroxy-7-methoxyflavanone; PN) is a natural active ingredient with numerous biological activities extensively utilized in tumour chemotherapy.
Bassam Ali Abed Wahab, Nur Ain Salehen, Mahmood Ameen Abdulla, Ahmed A.j. Jabbar, Ibrahim Abdel Aziz Ibrahim, Ghassan Almaimani, Mustafa AbdulMonam Zainel, Ghazi A Bamagous, Riyad A Almaimani, Hussain A Almasmoum, Mazen M Ghaith, Wesam F Farrash, Yahya A Almutawif   +12 more
doaj   +2 more sources

Mesenchymal Stem Cells Cancel Azoxymethane-Induced Tumor Initiation [PDF]

Stem Cells, 2014
Abstract The role of mesenchymal stem cells (MSCs) in tumorigenesis remains controversial. Therefore, our goal was to determine whether exogenous MSCs possess intrinsic antineoplastic or proneoplastic properties in azoxymethane (AOM)-induced carcinogenesis.
Masanao, Nasuno, Yoshiaki, Arimura, Kanna, Nagaishi, Hiroyuki, Isshiki, Kei, Onodera, Suguru, Nakagaki, Shuhei, Watanabe, Masashi, Idogawa, Kentaro, Yamashita, Yasuyoshi, Naishiro, Yasushi, Adachi, Hiromu, Suzuki, Mineko, Fujimiya, Kohzoh, Imai, Yasuhisa, Shinomura   +14 more
openaire   +3 more sources

Parabacteroides distasonis attenuates toll‐like receptor 4 signaling and Akt activation and blocks colon tumor formation in high‐fat diet‐fed azoxymethane‐treated mice [PDF]

International Journal of Cancer, 2018
Gut dysbiosis may play an etiological role in colorectal tumorigenesis. We previously observed that the abundance of Parabacteroides distasonis (Pd) in stool was inversely associated with intestinal tumor burden and IL‐1β concentrations in mice. Here, we
Gar Yee Koh, Anne Kane, Kyongbum Lee, Qiaobing Xu, Xian Wu, Jatin Roper, Joel B. Mason, Jimmy W. Crott   +7 more
openalex   +2 more sources

Chemopreventive evaluation of a Schiff base derived copper (II) complex against azoxymethane-induced colorectal cancer in rats.

PLoS ONE, 2014
BackgroundBased on the potential of Schiff base compounds to act as sources for the development of cancer chemotherapeutic agents, this in vivo study was performed to investigate the inhibitory properties of the synthetic Schiff base compound Cu(BrHAP)2 ...
Maryam Hajrezaie, Pouya Hassandarvish, Soheil Zorofchian Moghadamtousi, Nura Suleiman Gwaram, Shahram Golbabapour, Abdrabuh Najihussien, Amel Abdullah Almagrami, Maryam Zahedifard, Elham Rouhollahi, Hamed Karimian, Somaye Fani, Behnam Kamalidehghan, Nazia Abdul Majid, Hapipah Mohd Ali, Mahmood Ameen Abdulla   +14 more
doaj   +2 more sources

Murine models of colorectal cancer: the azoxymethane (AOM)/dextran sulfate sodium (DSS) model of colitis-associated cancer

PeerJ, 2023
Background Colorectal cancer (CRC) is the third most common cancer. It is a heterogeneous disease, including both hereditary and sporadic types of tumors.
D. Dzhalilova, N. Zolotova, Nikolai Fokichev, O. Makarova   +3 more
semanticscholar   +1 more source

Upregulation of polycistronic microRNA-143 and microRNA-145 in colonocytes suppresses colitis and inflammation-associated colon cancer

Epigenetics, 2021
Because ADAM17 promotes colonic tumorigenesis, we investigated potential miRNAs regulating ADAM17; and examined effects of diet and tumorigenesis on these miRNAs.
Urszula Dougherty, Reba Mustafi, Hongyan Zhu, Xiaorong Zhu, Dilip Deb, Stephen C. Meredith, Fatma Ayaloglu-Butun, Michelle Fletcher, Arantxa Sanchez, Joel Pekow, Zifeng Deng, Nader Amini, Vani J Konda, Vijaya L. Rao, Atsushi Sakuraba, Akushika Kwesi, Sonia S Kupfer, Alessandro Fichera, Loren Joseph, John Hart, Fang He, Tong-Chuan He, Diana West-Szymanski, Yan Chun Li, Marc Bissonnette   +24 more
doaj   +1 more source

Azoxymethane Alters the Plasma Metabolome to a Greater Extent in Mice Fed a High-Fat Diet Compared to an AIN-93 Diet

Metabolites, 2021
Consumption of a high-fat diet (HFD) links obesity to colon cancer in humans. Our data show that a HFD (45% energy fat versus 16% energy fat in an AIN-93 diet (AIN)) promotes azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) formation in a ...
Huawei Zeng, Shahid Umar, Zhenhua Liu, Michael R. Bukowski   +3 more
doaj   +1 more source

Direct Comparison of the Thioacetamide and Azoxymethane Models of Type A Hepatic Encephalopathy in Mice

Gene Expression, 2018
Acute liver failure is a devastating consequence of hepatotoxic liver injury that can lead to the development of hepatic encephalopathy. There is no consensus on the best model to represent these syndromes in mice, and therefore the aim of this study was
Stephanie Grant, Matthew McMillin, Gabriel Frampton, Anca D. Petrescu, Elaina Williams, Victoria Jaeger, Jessica Kain, Sharon DeMorrow   +7 more
openalex   +3 more sources

Rumex japonicus Houtt. Extract Suppresses Colitis-Associated Colorectal Cancer by Regulating Inflammation and Tight-Junction Integrity in Mice

Frontiers in Pharmacology, 2022
Irritable bowel disease (IBD), which results in an elevated risk of colitis-associated colorectal cancer (CAC), is characterized by inflammation and barrier disruption of the gut.
Hee-Young Kim, Ji Eun Seo, Hanul Lee, Chang-Hwan Bae, Ki-Tae Ha, Ki-Tae Ha, Seungtae Kim, Seungtae Kim   +7 more
doaj   +1 more source

Parabacteroides distasonis attenuates tumorigenesis, modulates inflammatory markers, and promotes intestinal barrier integrity in azoxymethane-treated A/J mice.

Carcinogenesis, 2020
Imbalance of the gut microbial community promotes inflammation and colorectal cancer (CRC). Previously, we demonstrated that freeze-dried Parabacteroides distasonis (Pd) suppressed obesity-driven colorectal tumorigenesis in mice. Here, we investigated if
G. Y. Koh, A. Kane, Xian Wu, J. Crott
semanticscholar   +1 more source