Results 11 to 20 of about 15,583 (213)

Insufficient Expression of the Autophagic Protein ATG16L1 Results in Accelerated Carcinogenesis Related to an Aberrant B Cell Response. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background Autophagy‐related proteins (ATGs) regulate a great variety of cellular responses beyond autophagy. In cancer, the role of ATG proteins is central, as evidenced in spontaneous cancer emerging in animals lacking ATG proteins. Aim To determine whether ATG16L1 may be participating in tumorigenesis in colonic and oral mucosa and its ...
Mendiola D, Ortiz B, Nieto O, González MI, Vannan D, Eksteen B, Martínez A, Mateos D, Mendoza-Rodríguez MG, Rodríguez-Sosa M, Terrazas LI, Reyes JL.   +11 more
europepmc   +2 more sources

Mesenchymal Stem Cells Cancel Azoxymethane-Induced Tumor Initiation [PDF]

Stem Cells, 2014
Abstract The role of mesenchymal stem cells (MSCs) in tumorigenesis remains controversial. Therefore, our goal was to determine whether exogenous MSCs possess intrinsic antineoplastic or proneoplastic properties in azoxymethane (AOM)-induced carcinogenesis.
Masanao, Nasuno, Yoshiaki, Arimura, Kanna, Nagaishi, Hiroyuki, Isshiki, Kei, Onodera, Suguru, Nakagaki, Shuhei, Watanabe, Masashi, Idogawa, Kentaro, Yamashita, Yasuyoshi, Naishiro, Yasushi, Adachi, Hiromu, Suzuki, Mineko, Fujimiya, Kohzoh, Imai, Yasuhisa, Shinomura   +14 more
openaire   +2 more sources

Characterization of hepatic pathology during azoxymethane-induced acute liver failure. [PDF]

World J Gastroenterol
BACKGROUND Acute liver failure (ALF) is a loss of liver function due to a severe hepatic insult. Studies utilizing the azoxymethane (AOM) mouse model of ALF, which also generates hepatic encephalopathy, have primarily focused on development of neurological deficits.
Bhattarai SM, Jhawer A, Frampton G, Troyanovskaya E, DeMorrow S, McMillin M.   +5 more
europepmc   +3 more sources

Colon carcinogenesis in wild type and immune compromised mice after treatment with azoxymethane, and azoxymethane with dextran sodium sulfate [PDF]

Molecular Carcinogenesis, 2015
The association between inflammation and the risk of colorectal cancer (CRC) is well documented in animal models and in humans, but the mechanistic role of inflammation in CRC is less well understood. To address this question, the induction of colon tumors was evaluated in (i) wild type (WT) and athymic BALB/c mice treated with the colon carcinogen ...
Whetstone, Ryan D., Wittel, Uwe A., Michels, Nicole M., Gulizia, James M., Gold, Barry   +4 more
openaire   +3 more sources

Chemoprevention of aberrant crypt foci in the colon of rats by dietary onion [PDF]

, 2007
Onion intake might reduce the risk of colorectal cancer, according to epidemiology. However, Femia showed in 2003 that diets with a 20% onion intake increase carcinogenesis in rats. We speculated this dose was too high.
Corpet, Denis E., Ladam, Aélis, Taché, Sylviane   +2 more
core   +4 more sources

Dehydroalanine and Lysinoalanine in Thermolyzed Casein do not Promote Colon Cancer in the Rat [PDF]

, 2008
Thermolysis of proteins produces xenobiotic amino-acids such as the potentially toxic lysinoalanine, and the alkylating agent, dehydro¬alanine, which have been considered possible health hazards.
AIN, Bachmeier, Bartone, Bird, Cattaneo, Cheftel, Corpet, Corpet, Corpet, Corpet, Corpet, Corpet, Corpet, De Groot, Deng, Denis E. Corpet, D’Agostina, Finley, Friedman, Gerb er, Kleyn, Kumar, Lutz, Maga, Masri, Michael C. Archer, Parnaud, Pintauro, Sternberg, Struthers, Sugimura, Sylviane Taché, Vlassara, Vo, W. Robert Bruce, Wenzel, Zhang   +36 more
core   +3 more sources

American ginseng attenuates azoxymethane/dextran sodium sulfate-induced colon carcinogenesis in mice

Journal of Ginseng Research, 2015
Background: Colorectal cancer is a leading cause of cancer-related death, and inflammatory bowel disease is a risk factor for this malignancy. We previously reported colon cancer chemoprevention potential using American ginseng (AG) in a xenograft mice ...
Chunhao Yu, Xiao-Dong Wen, Zhiyu Zhang, Chun-Feng Zhang, Xiao-Hui Wu, Adiba Martin, Wei Du, Tong-Chuan He, Chong-Zhi Wang, Chun-Su Yuan   +9 more
doaj   +1 more source

Pinostrobin attenuates azoxymethane-induced colorectal cytotoxicity in rats through augmentation of apoptotic Bax/Bcl-2 proteins and antioxidants

SAGE Open Medicine, 2023
Objectives: Pinostrobin (5-hydroxy-7-methoxyflavanone; PN) is a natural active ingredient with numerous biological activities extensively utilized in tumour chemotherapy.
Bassam Ali Abed Wahab, Nur Ain Salehen, Mahmood Ameen Abdulla, Ahmed A.j. Jabbar, Ibrahim Abdel Aziz Ibrahim, Ghassan Almaimani, Mustafa AbdulMonam Zainel, Ghazi A Bamagous, Riyad A Almaimani, Hussain A Almasmoum, Mazen M Ghaith, Wesam F Farrash, Yahya A Almutawif   +12 more
doaj   +1 more source

Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved [PDF]

, 2011
Red meat and processed meat intake is associated with a risk of colorectal cancer, a major cause of death in affluent countries. Epidemiological and experimental evidence supports the hypothesis that heme iron present in meat promotes colorectal cancer ...
Bingham, Chen, Clinton, Cross, Cummings, de Vogel, Denis E. Corpet, Douglass, Fabrice H.F. Pierre, Grant, Leuratti, Marnett, Mirvish, Nadia M. Bastide, Nauss, Nutter, Parnaud, Pierre, Pierre, Sandhu, Sawa, Schwartz, Sesink, Shuker, Sinha   +24 more
core   +4 more sources

Induction of Colonic Aberrant Crypts in Mice by Feeding Apparent N-Nitroso Compounds Derived From Hot Dogs [PDF]

, 2012
Nitrite-preserved meats (e.g., hot dogs) may help cause colon cancer because they contain N-nitroso compounds. We tested whether purified hot-dog-derived total apparent N-nitroso compounds (ANC) could induce colonic aberrant crypts, which are putative ...
Caderni G, Denis E. Corpet, James L. Wisecarver, James M. Gulizia, Lin Zhou, McLellan E A, McLellan E A, McLellan E A, Michael E. Davis, Michal P. Lisowyj, Mirvish S S, Nathalie Naud, Newmark H L, Sidney S. Mirvish, Valerie K. Shostrom, Ward J M   +15 more
core   +5 more sources