Results 41 to 50 of about 21,150 (298)

Effect of Tarantula cubensis alcoholic extract and Nerium oleander distillate on cell proliferation markers in colon carcinogenesis

Revista Científica, 2022
Colorectal Cancer (CRC) is defined as colon and rectum cancer and is among the major causes of mortality in developed Countries. Tarantula cubensis alcoholic extract (TCAE) and Nerium oleander distillate (NOD) are reported to have anticancer and ...
Ozgur Ozdemir, Gokhan Akcakavak, Mehmet Tuzcu   +2 more
doaj   +1 more source

New Marker of Colon Cancer Risk Associated with Heme Intake: 1,4-Dihydroxynonane Mercapturic Acid [PDF]

, 2006
Background: Red meat consumption is associated with an increased risk of colon cancer. Animal studies show that heme, found in red meat, promotes preneoplastic lesions in the colon, probably due to the oxidative properties of this compound.
Bingham, Sheila A., Corpet, Denis E., Cross, Amanda J., Gasc, Nicole, Gottardi, Gaëlle, Guéraud, Françoise, Peiro, Géraldine, Pierre, Fabrice, Taché, Sylviane   +8 more
core   +4 more sources

Mouse Models for Application in Colorectal Cancer: Understanding the Pathogenesis and Relevance to the Human Condition

Biomedicines, 2022
Colorectal cancer (CRC) is a malignant disease that is the second most common cancer worldwide. CRC arises from the complex interactions among a variety of genetic and environmental factors. To understand the mechanism of colon tumorigenesis, preclinical
Chuangen Li, Harry Cheuk-Hay Lau, Xiang Zhang, Jun Yu   +3 more
doaj   +1 more source

Effects of 17β-Estradiol on Colonic Permeability and Inflammation in an Azoxymethane/Dextran Sulfate Sodium-Induced Colitis Mouse Model

Gut and Liver, 2018
Background/Aims Intestinal barrier dysfunction is a hallmark of inflammatory bowel diseases (IBDs) such as ulcerative colitis. This dysfunction is caused by increased permeability and the loss of tight junctions in intestinal epithelial cells. The aim of
Chin-Hee Song, Nayoung Kim, S. Sohn, S. Lee, R. Nam, H. Y. Na, D. H. Lee, Y. Surh   +7 more
semanticscholar   +1 more source

Calcium Carbonate Suppresses Haem Toxicity Markers without Calcium Phosphate Side Effect on Colon Carcinogenesis [PDF]

, 2010
Red meat intake is associated with increased risk of colorectal cancer. We have previously shown that haemin, haemoglobin and red meat promote carcinogen-induced preneoplastic lesions, aberrant crypt foci, in the colon of rats.
Belbraouet, Bruce, Bull, Cross, Denis E. Corpet, Diane Bahuaud, Fabrice H. F. Pierre, Karkare, Nathalie Naud, Ossama Allam, Pierre, Sesink, Sinha, Sylviane Taché, Van den Berg   +14 more
core   +5 more sources

Antibiotics suppress colon tumorigenesis through inhibition of aberrant DNA methylation in an azoxymethane and dextran sulfate sodium colitis model

Cancer Science, 2018
Chronic inflammation is involved in the development of colon cancer by inducing mutations and aberrant DNA methylation in colon epithelial cells. Furthermore, there is growing evidence that colonic microbiota modulates the inflammation response in the ...
Naoko Hattori, T. Niwa, T. Ishida, Kyosuke Kobayashi, T. Imai, Akiko Mori, Kana Kimura, Takeshige Mori, Y. Asami, T. Ushijima   +9 more
semanticscholar   +1 more source

Increased Incidence of Colon Tumors in AOM-Treated Apc1638N/+ Mice Reveals Higher Frequency of Tumor Associated Neutrophils in Colon Than Small Intestine

Frontiers in Oncology, 2019
Colorectal cancer (CRC) is one of the most common cancers and a major cause of mortality. Mice with truncating Apc germline mutations have been used as a standard model of CRC, but most of the Apc-mutated lines develop multiple tumors in the proximal ...
Rebecca Metzger, Mahulena Maruskova, Sabrina Krebs, Klaus-Peter Janssen, Anne B. Krug   +4 more
doaj   +1 more source

Deletion of glutathione peroxidase-2 inhibits azoxymethane-induced colon cancer development. [PDF]

PLoS ONE, 2013
The selenoprotein glutathione peroxidase-2 (GPx2) appears to have a dual role in carcinogenesis. While it protected mice from colon cancer in a model of inflammation-triggered carcinogenesis (azoxymethane and dextran sodium sulfate treatment), it ...
Mike F Müller, Simone Florian, Stefanie Pommer, Martin Osterhoff, R Steven Esworthy, Fong-Fong Chu, Regina Brigelius-Flohé, Anna P Kipp   +7 more
doaj   +1 more source

Dietary polyacetylenes, falcarinol and falcarindiol, isolated from carrots prevents the formation of neoplastic lesions in the colon of azoxymethane-induced rats.

Food & Function, 2017
Falcarinol (FaOH) and falcarindiol (FaDOH) are found in many food plants of the Apiaceae family. Carrots are a major dietary source of these polyacetylenes. Feeding azoxymethane (AOM)-induced rats with carrots and purified FaOH have previously been shown
M. Kobaek-Larsen, R. El-Houri, L. Christensen, I. al-Najami, X. Fretté, G. Baatrup   +5 more
semanticscholar   +1 more source

Processed Meat and Colorectal Cancer: A Review of Epidemiologic and Experimental Evidence [PDF]

, 2008
Processed meat intake may be involved in the etiology of colorectal cancer, a major cause of death in affluent countries. The epidemiologic studies published to date conclude that the excess risk in the highest category of processed meat-eaters is ...
Corpet, Denis E., Pierre, Fabrice, Santarelli, Raphaëlle L.   +2 more
core   +4 more sources