Results 61 to 70 of about 21,150 (298)

Apc mutation induces resistance of colonic cells to lipoperoxide-triggered apoptosis induced by faecal water from haem-fed rats [PDF]

, 2006
Recent epidemiological studies suggest that high meat intake is associated with promotion of colon cancer linked to haem-iron intake. We previously reported that dietary haem, in the form of either haemoglobin or meat, promotes precancerous lesions in ...
Guéraud, Françoise, Jourdan, Marie-Lise, Petit, Claude, Pierre, Fabrice, Rerole, Anne-Laure, Taché, Sylviane   +5 more
core   +1 more source

Comparative study of 1,2-dimethylhydrazine and azoxymethane on the induction of colorectal cancer in rats

Journal of Coloproctology, 2014
The induced colorectal carcinogenesis in rodents has a long history and currently uses the substances 1,2-dimethylhydrazine and azoxymethane. Objective: The aim of this study was to compare the inductive effect of the substances azoxymethane and 1,2 ...
Mario Jorge Jucá, Bruno Carneiro Bandeira, Davi Silva Carvalho, Antenor Teixeira Leal   +3 more
doaj   +1 more source

Bekatul Beras Hitam Terfermentasi Memperbaiki Kondisi Kolon Mencit yang Diinduksi Senyawa Karsinogen Azoxymethane

Jurnal Teknologi dan Industri Pangan, 2023
Worldwide, colon cancer has become the fourth cause of death in terms of cancer. A high fiber and antioxidants diet help promote a healthy diet and prevent colon cancer. Black rice bran has high content both in fiber and phenolic.
Nouverra Nadya Putri, Slamet Budijanto, Endang Prangdimurti, Bambang Pontjo   +3 more
doaj   +1 more source

Study on the effect and mechanism of Lacticaseibacillus rhamnosus AFY06 on inflammation-associated colorectal cancer induced by AOM/DSS in mice

Frontiers in Microbiology
IntroductionLacticaseibacillus rhamnosus AFY06 (LR-AFY06) is a microorganism isolated from naturally fermented yogurt in Xinjiang, China.MethodsIn this study, we investigated the effects and mechanisms of LR-AFY06 in a mouse model of inflammation ...
Jing Zhang, Piyun Zhang, Sijia Li, Ting Yu, Xiangyu Lai, Yongpeng He   +5 more
doaj   +1 more source

EFEK PEMBERIAN EKSTRAK DAUN CARICA PUBESCENS TERHADAP JUMLAH NEUTROFIL PADA TIKUS SPRAGUE DAWLEY YANG DIINDUKSI AZOXYMETHANE

Jurnal Kedokteran Diponegoro, 2019
Latar Belakang : Inflamasi yang terjadi terus menerus adalah salah satu penyebab terjadinya kanker kolorektal. Ekstrak daun Carica pubescens mengandung flavonoid yang memiliki efek antiinflamasi diyakini mampu menurunkan jumlah sel neutrofil.
Faradilla Nadya Blezeinsky, Ainun Rahmasari Gumay, Hardian Hardian   +2 more
doaj   +1 more source

Uncoupled nitric oxide synthase activity promotes colorectal cancer progression

Frontiers in Oncology, 2023
Increased levels of reactive oxygen/nitrogen species are one hallmark of chronic inflammation contributing to the activation of pro-inflammatory/proliferative pathways. In the cancers analyzed, the tetrahydrobiopterin:dihydrobiopterin ratio is lower than
Asim Alam, Steven C. Smith, Sundaresan Gobalakrishnan, Mina McGinn, Vasily A. Yakovlev, Christopher S. Rabender   +5 more
doaj   +1 more source

Lactoferrin's anti-cancer properties. Safety, selectivity, and wide range of action [PDF]

, 2020
Despite recent advances in cancer therapy, current treatments, including radiotherapy, chemotherapy, and immunotherapy, although beneficial, present attendant side effects and long-term sequelae, usually more or less affecting quality of life of the ...
Bonaccorsi di Patti, M. C., Cutone, A., Ianiro, G., Lepanto, M. S., Musci, G., Rosa, L., Valenti, P.   +6 more
core   +1 more source

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, EarlyView.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source

Comparison of 2 different mouse models of colorectal cancer and their application

陆军军医大学学报
Objective To establish and compare the characteristics of mouse models of colorectal cancer (CRC) induced by inflammation and gene mutation. Methods Inflammation-induced colorectal cancer mouse model was established using azoxymethane (AOM) combined with
FENG Jianhua, LIU Xiangjun, HUANG Yujun
doaj   +1 more source

Inulin‐Based Oral Chemotherapy Modulates Gut Microbiota and Immune Microenvironment through Inhibition of Neutrophil Extracellular Trap Formation for Improving Cancer Therapy

Advanced Science, EarlyView.
Schematic representation of ZIF‐8@OXA@inulin for cancer immunotherapy. Synthesis of ZIF‐8@OXA@inulin. Augmentation of pyroptosis, regulation of gut microbiota, and inhibition of NETs formation by ZIF‐8@OXA@inulin‐mediated comprehensive strategy for antitumor immune response. ABSTRACT Despite the potential of chemoimmunotherapy against colorectal cancer
Zhenhao Li, Jiaqiang Jiang, Yuping Zhou, Xinyuan Mao, Haotian Wen, Zhian Chen, Yutong Wang, Cong Huang, Yanfeng Hu   +8 more
wiley   +1 more source