Results 61 to 70 of about 15,583 (213)

EFEK PEMBERIAN EKSTRAK DAUN Carica pubescens TERHADAP JUMLAH LEUKOSIT PADA TIKUS Sprague Dawley YANG DIINDUKSI AZOXYMETHANE : STUDI DI LABORATORIUM PENELITIAN DAN PENGUJIAN TERPADU 4 UNIVERSITAS GADJAH MADA

Jurnal Kedokteran Diponegoro, 2019
Latar belakang: Inflamasi adalah salah satu faktor penyebab terjadinya kanker kolorektal. Flavonoid adalah suatu senyawa yang terkandung dalam daun Carica pubescens diyakini memiliki efek antiinflamasi.
Eka Meyliana Sugeng, Ainun Rahmasari Gumay, Saekhol Bakri   +2 more
doaj   +1 more source

Correlation Between THSD7A Expression and Tumor Characteristics of Azoxymethane-Induced Colon Cancer Model in Rats

The Turkish Journal of Gastroenterology, 2021
Background: Thrombospondin type 1 domain-containing 7A (THSD7A) has emerged as a new potential molecular tool for multiple tumors since that THSD7A was detected to be expressed in various malignant tumor types including colorectal cancer (CRC).
Oktay Halit Aktepe, Taha Koray Sahin, Gurkan Guner, Deniz Can Guven, Haci Hasan Yeter, Olcay Kurtulan, Ibrahim Hanifi Ozercan, Omer Dizdar, Suayib Yalcin   +8 more
doaj   +1 more source

Reduction of colonic inflammation in HLA-B27 transgenic rats by feeding Marie Ménard apples, rich in polyphenols [PDF]

, 2009
Inflammatory bowel diseases (IBD) are immunomediated ailments affecting millions of individuals. Although diet is regarded as an important factor influencing IBD, there are no accepted dietary recommendations presently available.
Baron, A., Bigagli, E., Caderni, G., Castagnini, C., Dolara, P., Eijssen, L., Evelo, C., Femia, A.P., Gaj, S., Giovannelli, L., Lodovici, M., Luceri, C., Martin, R., Messerini, L., Pitozzi, V., Renard, C.M., Salvadori, M., Toti, S., Zoetendal, E.G.   +18 more
core   +3 more sources

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

Genetic and microbial determinants of azoxymethane-induced colorectal tumor susceptibility in Collaborative Cross mice and their implication in human cancer

Gut Microbes
The insights into interactions between host genetics and gut microbiome (GM) in colorectal tumor susceptibility (CTS) remains lacking. We used Collaborative Cross mouse population model to identify genetic and microbial determinants of Azoxymethane ...
Dan Li, Chenhan Zhong, Mengyuan Yang, Li He, Hang Chang, Ning Zhu, Susan E Celniker, David W Threadgill, Antoine M Snijders, Jian-Hua Mao, Ying Yuan   +10 more
doaj   +1 more source

Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice Estudo da ação antineoplásica da Tabebuia avellanedae (Ipê-Roxo) na carcinogênese induzida pelo azoximetano em camundongos

Acta Cirúrgica Brasileira, 2011
PURPOSE: To study the antitumor action of Tabebuia avellanedae in experimentally induced colon carcinogenesis by azoxymethane in mice. METHODS: Fifty (n=50) mice were divided into five groups: in group I azoxymethane (AOM) was administered, in Group II -
Roberta Alves Higa, Ricardo Dutra Aydos, Iandara Schettert Silva, Rondon Tosta Ramalho, Albert Schiaveto de Souza   +4 more
doaj   +1 more source

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, Volume 13, Issue 9, 13 February 2026.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source

Gut microbiota mediated the toxicity of high concentration of dietary nitrite in C57BL/6 mice

Ecotoxicology and Environmental Safety, 2022
Growing evidence indicates that exposure to high levels of nitrite for a prolonged time has adverse health effects. Although gut microbiota is responsible for the transformation of nitrite in the gut, the evidence concerning whether gut microbiota ...
Jing Xu, Mingzhu Wang, Qiuping Liu, Xiaoying Lin, Kefeng Pu, Zhixing He   +5 more
doaj   +1 more source

The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia. [PDF]

, 2018
Guanylate cyclase C (GUCY2C) is a transmembrane receptor expressed on the luminal aspect of the intestinal epithelium. Its ligands include bacterial heat-stable enterotoxins responsible for traveler\u27s diarrhea, the endogenous peptide hormones ...
Rappaport, Jeffrey A., Waldman, Scott A.
core   +2 more sources

Bifidobacterium animalis ssp. lactis BX-245-fermented milk alleviates tumor burden in mice with colorectal cancer

Journal of Dairy Science
: Colorectal cancer (CRC) arises from the accumulation of abnormal mutations in colorectal cells during prolonged inflammation. This study aimed to investigate the potential of probiotic fermented milk containing the probiotic strain, Bifidobacterium ...
Chengcong Yang, Musu Zha, Lu Li, Jiaqi Qiao, Lai-Yu Kwok, Dandan Wang, Yongfu Chen   +6 more
doaj   +1 more source