Results 101 to 110 of about 16,733 (229)

Impact of chromosomally encoded resistance mechanisms and transferable β-lactamases on the activity of cefiderocol and innovative β-lactam/β-lactamase inhibitor combinations against Pseudomonas aeruginosa [PDF]

[Abstract] Objectives: We aimed to compare the stability of the newly developed β-lactams (cefiderocol) and β-lactam/β-lactamase inhibitor combinations (ceftazidime/avibactam, ceftolozane/tazobactam, aztreonam/avibactam, cefepime/taniborbactam ...
Alonso-García, Isaac, Arca-Suárez, Jorge, Beceiro, Alejandro, Blanco-Martín, Tania, Bou, Germán, Camacho-Zamora, Pablo, Fraile-Ribot, Pablo Arturo, González-Pinto, Lucía, Guijarro-Sánchez, Paula, Juan, Carlos, Lasarte-Monterrubio, Cristina, Maceiras, Romina, Moya, Bartolomé, Oliver, Antonio, Outeda, Michelle, Vázquez-Ucha, Juan Carlos   +15 more
core   +1 more source

Selection of mutants with resistance or diminished susceptibility to ceftazidime/avibactam from ESBL- and AmpC- producing Enterobacteriaceae [PDF]

, 2018
Introduction: Difficult Gram-negative infections are increasingly treated with new β-lactamase inhibitor combinations, e.g. ceftazidime/avibactam.
Doumith, Michel, Jamrozy, Dorota, Livermore, David M., Mushtaq, Shazad, Nichols, Wright W., Woodford, Neil   +5 more
core   +1 more source

Screening the Antibiotic Activity of Cave Actinobacteria Against Multidrug‐Resistant Strains of Pseudomonas aeruginosa and Methicillin‐Resistant Staphylococcus aureus

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Many antibiotics originate from soil‐inhabiting Actinobacteria, especially from the diverse genus Streptomyces. However, the emergence of antibiotic resistance poses a significant global challenge to treating infectious diseases. Therefore, the search for Actinobacteria, particularly from less‐explored environments, as potential sources of novel ...
Rajani Balkrishna Rao, Katelyn Boase, Cornelia Wuchter, Clem Kuek, Kliti Grice, Marco J. L. Coolen, Guilherme Dilarri   +6 more
wiley   +1 more source

In Vitro Activities of Aztreonam-avibactam and Comparator Agents against Metallo-β-lactamase-producing Enterobacterales Collected in the Middle East and Africa, ATLAS Global Surveillance Program, 2018-2022

International Journal of Infectious Diseases
Background: Aztreonam-avibactam is a β-lactam/β-lactamase inhibitor combination being developed for use against carbapenem-resistant Enterobacterales (CRE), particularly those carrying metallo-β-lactamases (MBLs).
Dr Mark Estabrook, Dr Gregory Stone, Dr Daniel Sahm   +2 more
doaj   +1 more source

A practical laboratory method to determine ceftazidime-avibactam-aztreonam synergy in patients with New Delhi Metallo-beta-lactamase (NDM) producing Enterobacterales infection [PDF]

, 2022
Background: In response to infection with New Delhi Metallo-beta-lactamase (NDM) producing Enterobacterales, combination antimicrobial therapy with ceftazidime/avibactam (CAZ/AVI) plus aztreonam (ATM) has been explored.
Almeida, M, Brzeska-Trafny, I, Davies, F, Donaldson, H, Gilchrist, M, Gonzalo, X, Maxfield, R, Moore, L, Rawson, TM   +8 more
core   +1 more source

Effect of modification of penicillin-binding protein 3 on susceptibility to ceftazidime-avibactam, imipenem-relebactam, meropenem-vaborbactam, aztreonam-avibactam, cefepime-taniborbactam, and cefiderocol of Escherichia coli strains producing broad-spectrum β-lactamases

Antimicrobial Agents and Chemotherapy
The impact of penicillin-binding protein 3 (PBP3) modifications that may be identified in Escherichia coli was evaluated with respect to susceptibility to β-lactam/β-lactamase inhibitor combinations including ceftazidime-avibactam, imipenem-relebactam ...
C. Le Terrier, P. Nordmann, Chloé Buchs, L. Poirel   +3 more
semanticscholar   +1 more source

Abstract Supplement

Pulmonary Medicine, Volume 2026, Issue 1, 2026.
 
Marzia Folegani, Semonti Nandi
wiley   +1 more source

MBLs, Rather Than Efflux Pumps, Led to Carbapenem Resistance in Fosfomycin and Aztreonam/Avibactam Resistant Elizabethkingia anophelis

Infection and Drug Resistance, 2021
To assess the risk factors associated with infections and in-hospital mortality, antimicrobial susceptibility patterns and carbapenem resistance mechanisms in E. anophelis.This retrospective case-control study was conducted to reveal the risk factors associated with Elizabethkingia anophelis (E.
Yanbin Chang, Daiqin Zhang, Siqiang Niu, Qian Chen, Qiuxia Lin, Xiaobing Zhang   +5 more
openaire   +5 more sources

Aztreonam Combinations with Avibactam, Relebactam, and Vaborbactam as Treatment for New Delhi Metallo-β-Lactamase-Producing Enterobacterales Infections—In Vitro Susceptibility Testing

Pharmaceuticals
Antimicrobial resistance is a major global health issue. Metallo-β-lactamases (MBL), in particular, are problematic because they can inactivate all classes of β-lactams except aztreonam.
Małgorzata Brauncajs, Filip Bielec, Marlena Malinowska, Dorota Pastuszak-Lewandoska   +3 more
doaj   +1 more source

The challenge of treating infections caused by metallo-β-lactamase-producing gram-negative bacteria: a narrative review [PDF]

Review[Abstract] Gram-negative multidrug-resistant (MDR) bacteria, including Enterobacterales, Acinetobacter baumannii, and Pseudomonas aeruginosa, pose a significant challenge in clinical practice.
Bou, Germán, Hidalgo-Tenorio, Carmen, Martínez-Martínez, Luis, Oliver, Antonio, Rodríguez‑Aguirregabiria, Montserrat, Salavert, Miguel   +5 more
core   +2 more sources