Results 81 to 90 of about 16,733 (229)

Emergence and Genomic Characterization of a Hypervirulent Klebsiella pneumoniae Isolate From a New Clone in Brazil

Microbiology and Immunology, Volume 70, Issue 5, Page 261-267, May 2026.
ABSTRACT Hypervirulent Klebsiella pneumoniae (hvKp) has emerged globally as a major public health concern, often associated with severe community‐acquired and healthcare‐associated human infections. Despite alerts from PAHO/WHO on convergent hvKp strains with multidrug resistance in Latin America, comprehensive data from Brazil, the region's largest ...
Carlos Henrique Camargo, Ana Beatriz Nascimento Costa, Amanda Yaeko Yamada, Daniel de Sena Miranda, Pedro Smith Pereira Ferraro, Andreia Rodrigues de Souza, Amanda Maria de Jesus Bertani, Karoline Rodrigues Campos, Marlon Benedito Nascimento Santos, Rafaela Mastrangelo Rissetti, Carolina Lechinski de Paula, Patrik Júnior de Lima Paz, Maria Solange Duarte Soares, Christiane Salvador, Giovanna de Pinho Pieri, Jorge Siguemassa Higa, Daniela dos Santos Souza, Márcio Garcia Ribeiro, Claudio Tavares Sacchi, Monique Ribeiro Tiba‐Casas, Geraldine Madalosso, Denise Brandao de Assis   +21 more
wiley   +1 more source

Clinical Outcome Associated With Beta‐Lactam Allergy Labels in Hospitalized Patients in Belgium

Clinical and Translational Allergy, Volume 16, Issue 4, April 2026.
ABSTRACT Background In the United States, beta‐lactam allergy labels (BLAL) are documented in 9%–16% of hospitalized patients and associated with worse clinical outcomes such as increased mortality, length of hospital stay (LOS), intensive care unit (ICU) admission, and use of alternative antibiotics, providing an incentive for broad delabeling ...
Liesbeth Gilissen, Greet Van De Sijpe, Annouschka Laenen, Peter Declercq, Dries Wets, Ileana Ghiordanescu, Anca Mirela Chiriac, Willy E. Peetermans, Paul De Munter, Isabel Spriet, Rik Schrijvers   +10 more
wiley   +1 more source

The Evaluation of Machine Learning Models Using Matrix‐Assisted Laser Desorption/Ionization Time‐of‐Flight Mass Spectrometry (MALDI–TOF–MS) Spectra for the Prediction of Antibiotic Resistance in Klebsiella pneumoniae

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
Machine learning models developed from matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry spectra can rapidly predict antimicrobial resistance in Klebsiella pneumoniae. By transforming routine spectral data into accurate resistance profiles within minutes, this approach could reduce diagnostic delays and support earlier ...
Stephen Mark Edward Fordham
wiley   +1 more source

Activity of Aztreonam-Avibactam against Enterobacterales Resistant to Recently Approved Beta-Lactamase Inhibitor Combinations Collected in Europe, Latin America, and the Asia-Pacific Region (2020-2022).

International Journal of Antimicrobial Agents
Aztreonam-avibactam is under clinical development for treatment of infections caused by carbapenem-resistant Enterobacterales (CRE), especially those resistant to recently approved β-lactamase inhibitor combinations (BLICs).
H. Sader, C. Carvalhaes, J. Kimbrough, R. Mendes, M. Castanheira   +4 more
semanticscholar   +1 more source

Evaluation of a simple method for testing aztreonam and ceftazidime-avibactam synergy in New Delhi metallo-beta-lactamase producing Enterobacterales.

PLoS ONE
NDM-producing carbapenem-resistant bacterial infections became a challenge for clinicians. Combination therapy of aztreonam and ceftazidime-avibactam is a prudent choice for these infections.
Salman Khan, Arghya Das, Deepali Vashisth, Anwita Mishra, Ashima Jain Vidyarthi, Raghav Gupta, Nazneen Nahar Begam, Babita Kataria, Sushma Bhatnagar   +8 more
doaj   +1 more source

In vitro activity of cefiderocol and other newly approved antimicrobials against multi-drug resistant Gram-negative pathogens recovered in intensive care units in Spain and Portugal [PDF]

, 2023
[Abstract] Objective: The antimicrobial resistance is a significant public health threat, particularly for healthcare-associated infections caused by carbapenem-resistant Gram-negative pathogens which are increasingly reported worldwide.
Bou, Germán, Calvo-Montes, Jorge, Cantón, Rafael, Cruz, Hugo, Fernández-López, María del Carmen, García-Castillo, María, Gijón, Desiree, Gimeno, Concepción, Mulet, Xavier, Oliver, Antonio, Pitart, Cristina, Ramos, Helena, Ruiz-Garbajosa, Patricia, Siller, María, Torno, Nuria, Vila, Jordi   +15 more
core   +1 more source

Bloodstream Infection Caused by Carbapenemase‐Producing Enterobacterales in a Tertiary Hospital of Colombia: A 6 Year Retrospective Study

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Background The global spread of carbapenemase‐producing Enterobacterales (CPE) has emerged as a significant public health challenge. However, epidemiological studies on CPE infections in Latin America remain scarce. This study aims to characterize bloodstream infections (BSIs) caused by CPE at a tertiary hospital over a 6‐year period and analyze the ...
Juan David Cáceres-González, Jorge Álvarez, Lorena Matta-Cortés, Ernesto Martínez-Buitrago, Johann A. Ospina-Galindez, Claudia C. Paredes-Amaya, Bishnu P. Marasini   +6 more
wiley   +1 more source

In Vitro Activity of Aztreonam-avibactam and Comparator Agents Against Carbapenemase-producing Enterobacterales Collected in Turkey and the Middle East as Part of the ATLAS Surveillance Program: 2018-2022

Journal of Global Antimicrobial Resistance
BACKGROUND: Aztreonam-avibactam is approved in the European Union for treatment of hospital/ventilator acquired bacterial pneumonia, complicated intraabdominal infection, complicated urinary tract infection and infections where treatment options are ...
Mark Estabrook, Meredith Hackel, Gregory Stone, Katherine Perez, Daniel Sahm   +4 more
doaj   +1 more source

P-105. Aztreonam-Avibactam Compared with Adjunctive Colistin Combined with Meropenem for the Treatment of Serious Gram-Negative Bacterial Infections: Subgroup Analysis of the Phase 3 REVISIT Study

Open Forum Infectious Diseases
Background In the phase 3 REVISIT trial, efficacy of aztreonam-avibactam ± metronidazole (ATM-AVI ± MTZ) was similar to meropenem ± colistin (MER ± COL) in patients with complicated intra-abdominal infection (cIAI) or hospital-acquired/ventilator ...
H. Leister-Tebbe, Jinyi Yuan, Y. Carmeli, J. Cisneros, Georgios L Daikos, Mical Paul, Yongjie Zhao, Jinfu Xu, Ying Ma, Wenjuan Xu, Michele Wible, Joanne Leaney, Minggui Wang   +12 more
semanticscholar   +1 more source

2893 A. Efficacy and Safety of Aztreonam-Avibactam for the Treatment of Serious Infections Due to Gram-Negative Bacteria, Including Metallo-β-Lactamase-Producing Pathogens: Phase 3 REVISIT Study

Open Forum Infectious Diseases, 2023
Background Multidrug resistant (MDR) Gram-negative bacteria, including metallo-β-lactamase (MBL) producers, pose significant treatment challenges.
Y. Carmeli, J. Cisneros, Mical Paul, Georgios L Daikos, Minggui Wang, J. T. Cisneros, George Singer, Ivan Titov, Illia Gumenchuk, Yongjie Zhao, R. J. Jiménez Rodríguez, Lu Liang, Gang Chen, Oleksandr Pyptiuk, Firdevs Aksoy, Halley Rogers, M. Wible, Francis F Arhin, Alison Luckey, Joanne Leaney, Rienk Pypstra, Joseph W Chow   +21 more
semanticscholar   +1 more source