Results 91 to 100 of about 9,189 (185)

Aztreonam/avibactam activity against clinical isolates of Enterobacterales collected in Europe, Asia and Latin America in 2019

Journal of Antimicrobial Chemotherapy, 2020
Abstract Background Aztreonam is a monobactam stable to hydrolysis by metallo-β-lactamases (MBLs) and avibactam is a non-β-lactam β-lactamase inhibitor that effectively inhibits serine carbapenemases (CPs). Aztreonam/avibactam is under clinical development for treatment of serious infections caused by
Helio S, Sader, Cecilia G, Carvalhaes, S J Ryan, Arends, Mariana, Castanheira, Rodrigo E, Mendes   +4 more
openaire   +2 more sources

Molecular Characterization of Carbapenem-Nonsusceptible Enterobacterial Isolates Collected during a Prospective Interregional Survey in France and Susceptibility to the Novel Ceftazidime-Avibactam and Aztreonam-Avibactam Combinations

, 2016
International audienceAn interregional surveillance program was conducted in the northwestern part of France to determine the prevalence of carbapenem-nonsusceptible Enterobacteriaceae (CNSE) isolates and their susceptibility to ceftazidime-avibactam and
Plassart, Claire, Dupont, Herve, Mammeri, Hedi, Gaillot, Olivier, Cattoir, Vincent, Lecuru, Marion, Derdouri, Sarah, Emond, Jean-Philippe, Goetgheluck, Anne-Sophie, Gaillard, Nicolas, Courtilles, Marion Girard, De, Lemaire, Baptiste   +11 more
core   +1 more source

A Review of β‐Lactamase Inhibitors in Clinical Use and Development: Mechanisms, Spectrum, and Therapeutic Applications

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
β‐Lactam antibiotics have long served as a cornerstone for treating bacterial infections. However, their widespread and often indiscriminate use has fueled the emergence of multidrug‐resistant Gram‐negative pathogens, primarily through the production and dissemination of β‐lactamase enzymes.
Mohammad Javad Roustaye Gourabi, Anita Nikoo, Bita Khanbabaei, Masoud Kargar, Amirhossein Fayyazi, Seyyed Mohammad Javad Mousavi, Amirhossein Aghdaee, Ali Hashemi, Javad Yasbolaghi Sharahi, Swaran J. S. Flora   +9 more
wiley   +1 more source

Intravenous Compatibility of Ceftazidime-Avibactam and Aztreonam Using Simulated and Actual Y-site Administration.

, 2020
PURPOSE: The objective of this communication was to determine the intravenous compatibility of ceftazidime/avibactam and aztreonam using simulated and actual Y-site administration.
O'Donnell, J Nicholas, Lodise, Thomas P, Xu, Allan   +2 more
core   +1 more source

In vitro activity of ceftazidime, ceftaroline and aztreonam alone and in combination with avibactam against European Gram-negative and Gram-positive clinical isolates [PDF]

, 2015
Recent clinical isolates of key Gram-negative and Gram-positive bacteria were collected in 2012 from hospitalised patients in medical centres in four European countries (France, Germany, Italy and Spain) and were tested using standard broth microdilution
Harald Seifert, Nichols, Wright W., Rossolini, Gian Maria, María-Isabel Morosini, Danuta Stefanik, Nichols, Wright W, Rafael Cantón, Cantón, Rafael, Morosini, María-Isabel, Gian Maria Rossolini, Giani, Tommaso, Seifert, Harald, Patrice Nordmann, Tommaso Giani, Testa, Raymond, Morosini, María Isabel, Raymond Testa, Nordmann, Patrice, Stefanik, Danuta, Wright W. Nichols   +19 more
core   +1 more source

Screening the Antibiotic Activity of Cave Actinobacteria Against Multidrug‐Resistant Strains of Pseudomonas aeruginosa and Methicillin‐Resistant Staphylococcus aureus

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Many antibiotics originate from soil‐inhabiting Actinobacteria, especially from the diverse genus Streptomyces. However, the emergence of antibiotic resistance poses a significant global challenge to treating infectious diseases. Therefore, the search for Actinobacteria, particularly from less‐explored environments, as potential sources of novel ...
Rajani Balkrishna Rao, Katelyn Boase, Cornelia Wuchter, Clem Kuek, Kliti Grice, Marco J. L. Coolen, Guilherme Dilarri   +6 more
wiley   +1 more source

Abstract Supplement

Pulmonary Medicine, Volume 2026, Issue 1, 2026.
 
Marzia Folegani, Semonti Nandi
wiley   +1 more source

Genomic and Pathogenic Characterization of an Extensively Drug‐Resistant Avian Pathogenic Escherichia coli Strain

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Extensively drug‐resistant (XDR) avian pathogenic Escherichia coli (APEC) poses a global threat to poultry and public health. In this study, we isolated an APEC strain, SDLYRA415, from broilers in Shandong, China, during an outbreak with ~20% mortality.
Weishi Ni, Lijuan Chen, Hao Chen, Kejing Wang, Lumin Yu, Xinglin Zhang, Peikun Wang, Ganwu Li   +7 more
wiley   +1 more source

Longitudinal Analysis of the In Vitro Activity of Aztreonam-Avibactam and Comparator Agents Against Enterobacterales Collected in the Middle East/Africa Region for the ATLAS Surveillance Program, 2018-2022

International Journal of Infectious Diseases
Introduction: Enterobacterales commonly produce β-lactamases that can render members of the β-lactam class of antibacterial agents ineffective. Avibactam is a β-lactamase inhibitor active against class A, class C, and certain class D serine β-lactamases ...
Dr Mark Wise, Dr Gregory Stone, Dr Daniel Sahm   +2 more
doaj   +1 more source

Detection of blaNDM‐1 and blaIMP‐1 Metallo‐β‐Lactamases in Meropenem‐Resistant Clinical Escherichia coli Isolates Using Modified Carbapenem Inactivation Method (mCIM) and PCR Techniques

Journal of Clinical Laboratory Analysis, Volume 39, Issue 21, November 2025.
This study examines the prevalence of blaNDM‐1 and blaIMP‐1 metallo‐β‐lactamase genes in meropenem‐resistant Escherichia coli isolates using mCIM and PCR. The results indicate a higher prevalence of blaNDM‐1 and suggest the presence of alternative resistance mechanisms in some strains, emphasizing the need for further research on antimicrobial ...
Mehdi Roshdi Maleki
wiley   +1 more source