Results 111 to 120 of about 16,733 (229)

In vitro activities of the essential antimicrobial agents including aztreonam/avibactam, eravacycline, colistin, and other comparators against carbapenem-resistant bacteria with different carbapenemase genes: a multicenter study in China, 2021.

International Journal of Antimicrobial Agents
OBJECTIVE Carbapenem-resistant bacteria (CRB), including carbapenem-resistant Acinetobacter baumannii (CRAB), carbapenem-resistant Pseudomonas aeruginosa (CRPA), and carbapenem-resistant Enterobacterales (CRE), pose a considerable threat to public health
Yun Wu, Jiawei Chen, Ge Zhang, Jin Li, Tong Wang, Kang Wei, Jingjia Zhang, H. Sun, Yali Liu, Y. Xu   +9 more
semanticscholar   +1 more source

Detection of blaNDM‐1 and blaIMP‐1 Metallo‐β‐Lactamases in Meropenem‐Resistant Clinical Escherichia coli Isolates Using Modified Carbapenem Inactivation Method (mCIM) and PCR Techniques

Journal of Clinical Laboratory Analysis, Volume 39, Issue 21, November 2025.
This study examines the prevalence of blaNDM‐1 and blaIMP‐1 metallo‐β‐lactamase genes in meropenem‐resistant Escherichia coli isolates using mCIM and PCR. The results indicate a higher prevalence of blaNDM‐1 and suggest the presence of alternative resistance mechanisms in some strains, emphasizing the need for further research on antimicrobial ...
Mehdi Roshdi Maleki
wiley   +1 more source

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Ceftazidime-avibactam/aztreonam combination synergy against carbapenem-resistant Gram-negative isolates: In vitro study

Current Medicine Research and Practice
Background: The ceftazidime-avibactam combination is able to inhibit ESBLs, AmpCs and Class A carbapenemases and has been recommended for the treatment of complicated UTIs and ventilator-associated bacterial pneumonia.
Reena Rajan, A V Raghavendra Rao, Mathavi Suresh Kumar   +2 more
doaj   +1 more source

Amidine Syntheses from Classic to Contemporary for Medicinal Lead Compounds and Natural Products

European Journal of Organic Chemistry, Volume 28, Issue 40, October 29, 2025.
A revolution is underway in the synthesis of amidines with new methods unlocking complex, highly substituted amidines or closely related derivatives such as N‐sulfonyl amidines. This review surveys recent advances in amidines and related compounds, including methods to install them and bioactive molecules prominently featuring the amidine functionality.
Wyatt R. Swift‐Ramirez, Gregory A. Weiss   +1 more
wiley   +1 more source

Enhancement and Comparison of (Ceftazidime-)Avibactam Plus Aztreonam Susceptibility Tests for Stenotrophomonas maltophilia in Clinical Diagnostics [PDF]

Stenotrophomonas maltophilia is naturally resistant to many antimicrobials. We evaluated the in vitro activity and reproducibility of two different super-position methods of aztreonam in combination with ceftazidime-avibactam for S.
Bathoorn, Erik, Hughes, Laura A., Huis in ’t Veld, Robert A.G., Kampinga, Greetje A., Vlaspolder, Gro L.   +4 more
core   +1 more source

Interaction of Avibactam with Class B Metallo-β-Lactamases. [PDF]

, 2016
β-Lactamases are the most important mechanisms of resistance to the β-lactam antibacterials. There are two mechanistic classes of β-lactamases: the serine β-lactamases (SBLs) and the zinc-dependent metallo-β-lactamases (MBLs).
Abboud, Martine I, Brem, Jurgen, Claridge, Timothy DW, Damblon, C, Frère, JM, Gilbert, B, Mercuri, P, Rydzik, Anna M, Schofield, Christopher, Smargiasso, N   +9 more
core   +2 more sources

Phenotypic, Targeted Genotypic, and Antimicrobial Susceptibility Profiling of Extended‐Spectrum β‐Lactamase Production and Exclusive blaOXA−48 Gene Detection in Escherichia coli and Klebsiella pneumoniae Isolates From a South Lebanese Hospital

Journal of Clinical Laboratory Analysis, Volume 39, Issue 20, October 2025.
This study investigates the prevalence of multidrug‐resistant Escherichia coli and Klebsiella pneumoniae in South Lebanon's Saida region, focusing on ESBL and carbapenemase production. Results showed a high prevalence of ESBL producers (89.5%) and a lower rate of carbapenemase producers (10.5%), with blaCTX‐M being the most common ESBL gene.
Aya Kahil, Elie Salem Sokhn
wiley   +1 more source

Bioprospecting Heavy‐Metal Rhizospheres for Novel Therapeutics Against High‐Priority Multi‐Drug‐Resistant Pseudomonas aeruginosa and Acinetobacter baumannii: A Case of Toxic to Treatment

Environmental Microbiology Reports, Volume 17, Issue 5, October 2025.
Heavy metal stress induced the secretion of metabolites not secreted by non‐stressed microbiota. Heavy metal‐stressed microbiota secrete metabolites that inhibit XDR pathogens effectively. UPLC LC–MS tentatively identified novel metabolites, Tolyposamine and Gentiatibetine.
Kylah B. Millard, John O. Unuofin, Luke Invernizzi, Michael O. Daramola, Samuel A. Iwarere   +4 more
wiley   +1 more source

Treatment of multidrug-resistant Gram-negative skin and soft tissue infections [PDF]

, 2020
Purpose of reviewThe increase in skin and soft tissue infections (SSTI) because of multidrug-resistant (MDR) pathogens is a global concern. Although MDR Gram-negative bacteria (GNB) are often overlooked as a cause of SSTIs, their burden on the morbidity ...
Jabbour, Jean Francois, Kanj, Souha S., Sharara, Sima Lynn   +2 more
core   +1 more source