Results 131 to 140 of about 28,303 (242)

Curcumin: A new candidate for melanoma therapy?

, 2016
Melanoma remains among the most lethal cancers and, in spite of great attempts that have been made to increase the life span of patients with metastatic disease, durable and complete remissions are rare.
Banikazemi, Z., Mirzaei, H., Mirzaei, H.R., Mohammadi, M., Naseri, G., Pawelek, J.M., Peyvandi, M., Rezaee, R., Sahebkar, A., Salehi, H.   +9 more
core   +1 more source

The Immune Landscape of Acral Melanoma: From Basic to Clinical

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Acral melanoma (AM) is an aggressive melanoma subtype with poor prognosis and limited response to immune checkpoint inhibitors (ICIs). Despite increasing research efforts, the mechanisms underlying therapeutic resistance remain incompletely understood.
Lihong Jiang, Zhaotian Zhang
wiley   +1 more source

Phenolic Content, Antioxidant Activity, Phytochemical Diversity, and Toxicological Potential of Tetradenia riparia (Hochst.) Codd Leaves

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
ABSTRACT Tetradenia riparia (Hochst.) Codd is a medicinal plant widely used in traditional medicine. However, comprehensive studies integrating its chemical composition, antioxidant capacity, and toxicological safety are still limited. This study aimed to characterize the phenolic content, antioxidant activity, phytochemical diversity, and ...
Caroline dos Santos Giuliani, Carla Andressa Almeida Farias, Patrícia Kolling Marquezan, Karoline Longo de Aguiar, Elize Musachio, Andreara Rodrigues dos Reis, Nathália Cardoso de Afonso Bonotto, Fernanda Barbisan, Milene Teixeira Barcia, Ana Lúcia Souza Silva Mateus, Aline Sobreira Bezerra, José Laerte Nörnberg   +11 more
wiley   +1 more source

Saikosaponin A Inhibits Migration/Invasion and Triggers Cell‐Cycle Arrest and Autophagy‐Induced Cell Death in HCT116 Cells and In Vivo

Food Frontiers, Volume 7, Issue 3, May 2026.
Saikosaponin A from Radix Bupleuri inhibited colorectal cancer HCT116 cells with low toxicity. SSA induced S/G2‐M cell cycle arrest and triggered autophagy via mTOR inhibition. SSA suppressed metastasis by blocking PI3K/AKT signaling pathway. SSA significantly reduced tumor growth without apparent toxicity.
Xiu‐Xiu Zhang, Wang‐Wei Zhang, Run‐Hui Ma, Zhi‐Jing Ni, Kiran Thakur, Mohammad Rizwan Khan, Jian‐Guo Zhang, Zhao‐Jun Wei   +7 more
wiley   +1 more source

Resveratrol for Cancer Radio‐Sensitization: Ready for Prime Time or Future Perspective

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Resveratrol exerts antioxidant and anti‐inflammatory effects by reducing reactive oxygen species and suppressing NF‐κB and JAK/STAT signaling pathways. It modulates metabolic signaling through AMPK‐dependent inhibition of mTOR, influencing cell survival and inflammatory responses.
Maryam Fallah, Ali Soleimani, Ali Nouri, Melika Fallah, Alireza Haghighi, Ahmad Reza Dehpour, Abolfazl Zendehdel, Soraiya Ebrahimpour‐Koujan   +7 more
wiley   +1 more source

Anti-Melanogenic Effects of L-Theanine on B16F10 Cells and Zebrafish

Molecules
L-Theanine, a natural amino acid found in green tea (Camellia sinensis) leaves, is known for its diverse psychotropic effects. This study aimed to evaluate the inhibitory effect of L-theanine on melanin production and uncover its regulatory mechanism. We evaluated the anti-melanogenic activities of L-theanine in vitro and in vivo.
Chih-Li Yu, Haiyue Pang, Zhao Run, Guey-Horng Wang   +3 more
openaire   +3 more sources

Integrated Phytochemical Profiling and Multifunctional Bioactivities of Bellis annua Extracts Obtained by Distinct Extraction Techniques

ChemistryOpen, Volume 15, Issue 5, May 2026.
The present study evaluates the effect of maceration, Soxhlet, and ultrasound‐assisted extraction on the phytochemical composition and biological activities of Bellis annua. LC–ESI–MS/MS analysis revealed chlorogenic acid as the dominant compound, while UAE enhanced flavonoid content and overall antioxidant capacity.
Fatma Ozlem Kargin Solmaz, Cengiz Sarikurkcu, Bektaş Tepe   +2 more
wiley   +1 more source

Hyperdifferentiated murine melanoma cells promote adaptive anti-tumor immunity but activate the immune checkpoint system

OncoImmunology
Accumulating evidence suggests that phenotype switching of cancer cells is essential for therapeutic resistance. However, the immunological characteristics of drug-induced phenotype-switching melanoma cells (PSMCs) are unknown.
Yukie Ando, Yutaka Horiuchi, Sara Hatazawa, Momo Mataki, Akihiro Nakamura, Takashi Murakami   +5 more
doaj   +1 more source

Action of Carnosic Acid Against Melanoma: A Strategy for Selective Radiosensitization with Protection of Non-Tumoral Cells

Current Issues in Molecular Biology
Carnosic acid (CA) is a phenolic diterpene with high antioxidant activity that supports its radioprotective capacity. This study aims to determine whether the radiosensitizing effect of CA established in B16F10 melanoma cells also occurs in other melanin-
Amparo Olivares, Isabel de la Fuente, Daniel Gyingiri Achel, Ana María Mercado, José Antonio Garcia-Gamuz, María del Rosario Tudela, Miguel Alcaraz   +6 more
doaj   +1 more source

Effects of Resveratrol Derivatives on Melanogenesis and Antioxidant Activity in B16F10 Cells

International Journal of Molecular Sciences
Excessive melanogenesis causes abnormal pigmentation and a higher risk of skin disorders (e.g., melanoma). Resveratrol (RSV), a natural polyphenol, exerts antioxidant and anti-aging effects. However, the effects of RSV and its derivatives on melanogenesis remain unclear. This study investigated their effects on melanogenesis and antioxidant activity in
Soyeon Kim, Changho Jhin, Sullim Lee, Ho Sik Rho, Chan Yoon Park   +4 more
openaire   +2 more sources