Results 1 to 10 of about 385,065 (234)

Limited density of an antigen presented by RMA-S cells requires B7-1/CD28 signaling to enhance T-cell immunity at the effector phase. [PDF]

PLoS ONE, 2014
The association of B7-1/CD28 between antigen presenting cells (APCs) and T-cells provides a second signal to proliferate and activate T-cell immunity at the induction phase.
Xiao-Lin Li, Marjolein Sluijter, Elien M Doorduijn, Shubha P Kale, Harris McFerrin, Yong-Yu Liu, Yan Li, Madhusoodanan Mottamal, Xin Yao, Fengkun Du, Baihan Gu, Kim Hoang, Yen H Nguyen, Nichelle Taylor, Chelsea R Stephens, Thorbald van Hall, Qian-Jin Zhang   +16 more
doaj   +5 more sources

Fully human anti-B7-H4 antibody induces lysosome-dependent ferroptosis to reverse primary resistance to PD-1 blockade. [PDF]

J Immunother Cancer
Background Although immune checkpoint inhibitors (ICIs) have significantly improved outcomes for patients with certain cancers, their efficacy is largely confined to “hot” tumors characterized by robust infiltration of tumor-specific CD8+ T cells ...
Zhang R, Wang Y, Wu Y, Zheng B, Cao Q, Chen Y, Cao Z, Zhu Y, Zhou L, Zhang Q.   +9 more
europepmc   +2 more sources

The B7-1 cytoplasmic tail enhances intracellular transport and mammalian cell surface display of chimeric proteins in the absence of a linear ER export motif. [PDF]

PLoS ONE, 2013
Membrane-tethered proteins (mammalian surface display) are increasingly being used for novel therapeutic and biotechnology applications. Maximizing surface expression of chimeric proteins on mammalian cells is important for these applications.
Yi-Chieh Lin, Bing-Mae Chen, Wei-Cheng Lu, Chien-I Su, Zeljko M Prijovich, Wen-Chuan Chung, Pei-Yu Wu, Kai-Chuan Chen, I-Chiao Lee, Ting-Yi Juan, Steve R Roffler   +10 more
doaj   +2 more sources

Alternative immune checkpoints in immunoregulatory profile of cancer stem cells

Heliyon, 2023
Tumor-mediated bypass of immune checkpoint inhibitor (ICI) therapy with anti-programmed death-1 (PD-1), anti-programmed death-ligand 1 (PD-L1, also called B7–H1 or CD274) or anti-cytotoxic T lymphocyte associated antigen-4 (CTLA-4) is a challenge of ...
Keywan Mortezaee, Jamal Majidpoor
doaj   +1 more source

Augmented Innate and Adaptive Immune Responses Under Conditions of Diabetes–Filariasis Comorbidity

Frontiers in Immunology, 2021
Metainflammation, as seen in chronic diabetes subjects, impairs immunity and increases the susceptibility to infections. In the present study, the effect of diabetes on immune response against filariasis was studied.
Joy Manohar Sibi, Viswanathan Mohan, Saravanan Munisankar, Subash Babu, Vivekanandhan Aravindhan   +4 more
doaj   +1 more source

The homodimer interfaces of costimulatory receptors B7 and CD28 control their engagement and pro-inflammatory signaling

Journal of Biomedical Science, 2023
Background The inflammatory response is indispensable for protective immunity, yet microbial pathogens often trigger an excessive response, ‘cytokine storm’, harmful to the host. Full T-cell activation requires interaction of costimulatory receptors B7-1(
Andrey Popugailo, Ziv Rotfogel, Michal Levy, Orli Turgeman, Dalia Hillman, Revital Levy, Gila Arad, Tomer Shpilka, Raymond Kaempfer   +8 more
doaj   +1 more source

B7-H3 specific T cells with chimeric antigen receptor and decoy PD-1 receptors eradicate established solid human tumors in mouse models

OncoImmunology, 2020
The application of chimeric antigen receptor (CAR)-T cell therapy in patients with advanced solid tumors remains a significant challenge. Simultaneously targeting antigen and the solid tumor microenvironment are two major factors that greatly impact CAR ...
Baozhu Huang, Liqun Luo, Jun Wang, Bailin He, Rui Feng, Na Xian, Qiong Zhang, Lieping Chen, Gangxiong Huang   +8 more
doaj   +1 more source

Efficacy of B7-H3-Redirected BiTE and CAR-T Immunotherapies Against Extranodal Nasal Natural Killer/T Cell Lymphoma

Translational Oncology, 2020
Extranodal nasal natural killer (NK)/T cell lymphoma (ENKTCL) is a rare but highly aggressive subtype of non-Hodgkin lymphoma (NHL). Nevertheless, despite extensive research, the estimated 5-year overall survival of affected patients remains low ...
Meijun Zheng, Lingyu Yu, Juanjuan Hu, Zongliang Zhang, Haiyang Wang, Dan Lu, Xin Tang, Jianhan Huang, Kunhong Zhong, Zeng Wang, Yisong Li, Gang Guo, Shixi Liu, Aiping Tong, Hui Yang   +14 more
doaj   +1 more source

Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer

Journal of Experimental & Clinical Cancer Research, 2021
The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4)/B7 and programmed death 1 (PD-1)/ programmed cell death-ligand 1 (PD-L1) are two most representative immune checkpoint pathways, which negatively regulate T cell immune function during different ...
Hao Zhang, Ziyu Dai, Wantao Wu, Zeyu Wang, Nan Zhang, Liyang Zhang, Wen-Jing Zeng, Zhixiong Liu, Quan Cheng   +8 more
doaj   +1 more source

High TIL, HLA, and Immune Checkpoint Expression in Conventional High-Grade and Dedifferentiated Chondrosarcoma and Poor Clinical Course of the Disease

Frontiers in Oncology, 2021
PurposeThe aim of this study was to characterize chondrosarcoma tumor infiltration by immune cells and the expression of immunologically relevant molecules.
Sjoerd P. F. T. Nota, Sjoerd P. F. T. Nota, Ahmad Al-Sukaini, Ahmad Al-Sukaini, Shalin S. Patel, Shalin S. Patel, Francesco Sabbatino, G. Petur Nielsen, G. Petur Nielsen, Vikram Deshpande, Vikram Deshpande, Jennifer H. Yearley, Soldano Ferrone, Soldano Ferrone, Xinhui Wang, Joseph H. Schwab, Joseph H. Schwab   +16 more
doaj   +1 more source