Does B7-1 expression confer antigen-presenting cell capacity to tumors in vivo? [PDF]
The Journal of experimental medicine, 1996 Tumors engineered to express the costimulatory molecule B7-1 can elicit CD8+ cytotoxic T lymphocyte (CTL)-dependent antitumor responses in immunocompetent mice.
Alex Y.C. Huang +3 more
semanticscholar +3 more sources
B7-1 Engagement of Cytotoxic T Lymphocyte Antigen 4 Inhibits T Cell Activation in the Absence of CD28 [PDF]
The Journal of Experimental Medicine, 1998 Ligation of cytotoxic T lymphocyte antigen 4 (CTLA4) appears to inhibit T cell responses. Four mechanisms have been proposed to explain the inhibitory activity of CTLA4: competition for B7-1 and B7-2 binding by CD28; sequestration of signaling molecules ...
F. Fallarino, P. Fields, T. Gajewski
semanticscholar +3 more sources
Coexpression of B7-1 and antigen blocks tolerance induction to antigen presented by resting B cells.
The Journal of Immunology, 1996 To investigate a role for B cells as tolerogenic APCs in peripheral lymphoid organs, we have developed a system in which B cells from mice transgenic for the membrane-bound form of human mu-chain are transferred into nontransgenic recipients.
Victoria Nicole Yuschenkoff +3 more
semanticscholar +4 more sources
B7-1 or B7-2 Is Required to Produce the Lymphoproliferative Phenotype in Mice Lacking Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) [PDF]
The Journal of Experimental Medicine, 1999 The costimulatory molecules B7-1 and B7-2 regulate T lymphocyte activation by delivering activating signals through CD28 and inhibitory signals through cytotoxic T lymphocyte–associated antigen 4 (CTLA-4). The importance of CTLA-4–mediated inhibition was
D. Mandelbrot, A. McAdam, A. Sharpe
semanticscholar +3 more sources
Tissue immunogenicity: the role of MHC antigen and the lymphocyte costimulator B7-1.
The Journal of Immunology, 1996 Pancreatic islet transplantation represents a potential treatment for insulin-dependent diabetes mellitus. One approach to circumvent the requirement for recipient immune suppression is to reduce or eliminate the immunogenicity of the donor graft prior ...
M. Coulombe +5 more
semanticscholar +3 more sources
The Journal of Immunology, 1998 Cutaneous painting with reactive haptens induces contact sensitivity (CS) responses that are in vivo examples of T cell immunity. In contrast, high dose i.v. administration of the hapten can induce tolerance.
H. Ushio +5 more
semanticscholar +3 more sources
Exaggerated and persistent cutaneous delayed-type hypersensitivity in transgenic mice whose epidermal keratinocytes constitutively express B7-1 antigen. [PDF]
Journal of Clinical Investigation, 1994 Since mouse keratinocytes are tolerogenic antigen presenting cells for T cell activation, the expression of second signal molecules such as B7-1 was targeted to epidermal keratinocytes (KC) in vivo in transgenic mice. The expression vector used to create transgenic mice consisted of a keratin 14 promoter fused 5' to the full length open reading frame ...
A. Nasir +4 more
semanticscholar +3 more sources
Construction and characterization of a triple-recombinant vaccinia virus encoding B7-1, interleukin 12, and a model tumor antigen. [PDF]
JNCI Journal of the National Cancer Institute, 1998 Construction of recombinant viruses that can serve as vaccines for the treatment of experimental murine tumors has recently been achieved. The cooperative effects of immune system modulators, including cytokines such as interleukin 12 (IL-12) and costimulatory molecules such as B7-1, may be necessary for activation of cytotoxic T lymphocytes.
Miles W. Carroll +5 more
semanticscholar +3 more sources
B7-1/B7-2 Costimulation Regulates Plaque Antigen–Specific T-Cell Responses and Atherogenesis in Low-Density Lipoprotein Receptor–Deficient Mice [PDF]
Circulation, 2004 Background— Several lines of evidence indicate that T-cell responses influence the progression of atherosclerotic disease. Interferon-γ (IFN-γ)–producing T cells specific for lesional antigens, including oxidized LDLs and heat shock protein 60 (HSP60), may promote lesion development as well as plaque
C. Buono +5 more
semanticscholar +3 more sources
Costimulatory protein B7-1 enhances the cytotoxic T cell response and antibody response to hepatitis B surface antigen. [PDF]
Proceedings of the National Academy of Sciences, 1996 There is a need for more effective therapy for chronic virus infections. A principle natural mechanism for elimination of virus-infected host cells is activation of viral antigen-specific cytotoxic T lymphocytes (CTL). In an effort to develop methods of inducing virus-specific CTL responses that might be utilized in therapy of virus infections, we have
Xiaodun He +4 more
semanticscholar +3 more sources