Antigen-specific regression of established tumors induced by active immunization with irradiated IL-12- but not B7-1-transfected tumor cells. [PDF]
International Immunology, 1997 Transfection of modestly immunogenic tumors to express B7 family co-stimulator molecules results in their rejection by syngeneic mice, suggesting a possible clinical application in cancer patients. Immunization of naive mice with irradiated B7-1-transfected P1.HTR cells is sufficient to induce specific cytolytic T lymphocytes (CTL) and to protect ...
F. Fallarino +3 more
semanticscholar +3 more sources
Immunology, 1997 During the investigation of the role of protein synthesis in antigen‐presenting cell (APC) function of A20‐HL B lymphoma cells, we found that partial inhibition of protein synthesis enhanced their APC function. The treatment of A20‐HL cells with 0·313–2·5 μm emetine, an irreversible inhibitor of protein synthesis, decreased protein synthesis by 60–70%,
T. Aoi +3 more
semanticscholar +4 more sources
Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice. [PDF]
Proceedings of the National Academy of Sciences, 1994 Tolerance to peripheral antigens is thought to result from the inability of parenchymal tissue to stimulate T cells--an inability that is believed to relate to the lack of expression of the costimulatory signal(s) required for T-cell activation. To test this model, we generated transgenic mice expressing costimulatory molecule B7-1 on the B cells of ...
Sylvia Guerder +3 more
semanticscholar +3 more sources
Lack of B7-1/BB1 and B7-2/B70 expression on thyrocytes of patients with Graves' disease. Delivery of costimulatory signals from bystander professional antigen-presenting cells. [PDF]
Journal of Clinical Endocrinology & Metabolism, 1996 We have previously demonstrated that thyrocytes from patients with Graves' disease induce autologous peripheral blood T cell proliferation in response to soluble antigens, and a synergistic augmentation of T cell response by adding suboptimal numbers of monocytes.
N. Matsuoka +8 more
semanticscholar +4 more sources
Clinical and Experimental Immunology, 2003 SUMMARYTo explore the role of the 10-kDa Mycobacterium tuberculosis-specific secreted antigen (MTSA-10 or CFP-10) in modulation of macrophage function, J774 macrophages were transfected stably with DNA encoding MTSA-10. Compared to normal or mock-transfected controls, MTSA-10-expressing macrophages had markedly lower levels of co-stimulatory molecule ...
Balwan Singh +4 more
semanticscholar +4 more sources
Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28. [PDF]
International Immunology, 1998 Pertussis toxin (PT) is a major virulence factor of Bordetella pertussis which exerts a range of effects on the immune system, including the enhancement of IgE, IgA and IgG production, delayed-type hypersensitivity reactions, and the induction of experimental autoimmune diseases.
M. Ryan +4 more
semanticscholar +6 more sources
Keratinocyte expression of B7-1 in transgenic mice amplifies the primary immune response to cutaneous antigens. [PDF]
Proceedings of the National Academy of Sciences, 1994 Resting epidermal keratinocytes do not express B7-1 and other known CD28 counterligands with costimulatory activity. The absence of these costimulators on keratinocytes correlates with their ability to preferentially induce T-cell anergy instead of T-cell activation.
I R, Williams, R J, Ort, T S, Kupper
openaire +2 more sources
Immunity, 1995 Human memory B cells that carry mutated IgV region genes were isolated from tonsils by negative selection of IgD+ naive B cells and CD38+ germinal center B cells and plasma cells. They were mainly found within the intraepithelial areas, but not in the B cell follicles of human tonsils.
Yong-Jun Liu +5 more
semanticscholar +4 more sources
Induction of Antigen-Specific Tumor Immunity by Genetic and Cellular Vaccines against MAGE: Enhanced Tumor Protection by Coexpression of Granulocyte-Macrophage Colony-Stimulating Factor and B7-1 [PDF]
Molecular Medicine, 1996 A number of tumors express antigens that are recognized by specific cytotoxic T cells. The normal host immune responses, however, are not usually sufficient to cause tumor rejection. Using appropriate immunization strategies, tumor-specific antigens may serve as targets against which tumor-destructive immune responses can be generated.
H. Büeler, R. Mulligan
semanticscholar +3 more sources
T Cell Mediated Antibody lnvariance in an Immune Response Against A Bacterial Carbohydrate Antigen Requires CD28/B7–1 Costimulation [PDF]
Journal of Immunology Research, 2001 The humoral immune response against α(1 → 3) dextran (Dex) in BALB/c mice is characterized by the formation of predominantly IgM antibodies bearing the J558 idiotype. IgG antibodies do not appear in euthymic mice. In athymic animals however, the response proceeds to a vigorous IgG production.
Rademaekers, André +2 more
openaire +2 more sources