Results 31 to 40 of about 22,003 (134)
Blood, 2010 Abstract Oral tolerance is a key feature of intestinal immunity, generating systemic tolerance to fed antigens. However, the molecular mechanism mediating oral tolerance remains unclear. In this study, we examined the role of the B7 family members of costimulatory molecules in the establishment of oral tolerance.
Fukaya, Tomohiro +12 more
openaire +3 more sources
, 2011 Much of our knowledge regarding cancer immunotherapy has been derived from sarcoma models. However, translation of preclinical findings to bedside success has been limited in this disease, though several intriguing clinical studies hint at the potential ...
Gouw, Launce G +3 more
core +2 more sources
Synergistic effects of IL-4 and TNFα on the induction of B7-H1 in renal cell carcinoma cells inhibiting allogeneic T cell proliferation [PDF]
, 2014 BACKGROUND: The importance of B7-H molecules for the T cell/tumor communication and its impact on renal cell carcinoma (RCC) progression and prognosis has been recently described.
Barbara Seliger +4 more
core +2 more sources
Медицинская иммунология, 2014 . Cytotoxic/pro-apoptogenic effects of IFNα-induced dendritic cells (IFN-DCs) directed against Т-lymphocytes and NK cells were investigated in healthy donors.
T. V. Tyrinova +5 more
doaj +1 more source
Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire. [PDF]
, 2016 Staphylococcus aureus is both an important pathogen and a human commensal. To explore this ambivalent relationship between host and microbe, we analysed the memory humoral response against IsdB, a protein involved in iron acquisition, in four healthy ...
Abdiche, Yasmina +17 more
core +2 more sources
The PD-1/PD-L1 Axis and Virus Infections: A Delicate Balance [PDF]
, 2019 Programmed cell death protein (PD-1) and its ligands play a fundamental role in the evasion of tumor cells from antitumor immunity. Less well appreciated is the fact that the PD-1/PD-L1 axis also regulates antiviral immune responses and is therefore ...
Raftery, Martin J., Schönrich, Günther
core +1 more source
Specific zinc finger‐induced methylation of PD‐L1 promoter inhibits its expression
FEBS Open Bio, 2019 DNA methylation of promoter regions is often associated with epigenetic silencing of gene expression, and DNA methyltransferase (DNMTs) has been used to suppress gene expression.
Xue Li +11 more
doaj +1 more source
Frontiers in Immunology, 2019 Due to their ability to present foreign antigens and prime naïve T cells, macrophages, and dendritic cells (DCs) are referred to as professional antigen-presenting cells (APCs).
Dimitar B. Iliev +6 more
doaj +1 more source
Hantavirus-driven PD-L1/PD-L2 upregulation: An imperfect viral immune evasion mechanism [PDF]
, 2018 Viruses often subvert antiviral immune responses by taking advantage of inhibitory immune signaling. We investigated if hantaviruses use this strategy.
Abdelaziz, Mohammed O. +3 more
core +2 more sources
Immunological backbone of uveal melanoma: is there a rationale for immunotherapy? [PDF]
, 2019 No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors.
Alessandra Cassano +24 more
core +1 more source