Results 31 to 40 of about 21,980 (135)

Immunological backbone of uveal melanoma: is there a rationale for immunotherapy? [PDF]

, 2019
No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors.
Alessandra Cassano, Apte, Bill, Blom, Brigida Anna Maiorano, De Vries, Durie, Emilio Bria, Ericsson, Ernesto Rossi, Giampaolo Tortora, Gianluigi Petrone, Giovanni Schinzari, Guido Rindi, Ilaria Grazia Zizzari, Lagouros, Makitie, Maria Antonietta Blasi, Maria Grazia Sammarco, Marianna Nuti, Monica Maria Pagliara, Shaw, Sohn, Vincenzo Fiorentino, Whelchel   +24 more
core   +1 more source

Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance

Blood, 2010
Abstract Oral tolerance is a key feature of intestinal immunity, generating systemic tolerance to fed antigens. However, the molecular mechanism mediating oral tolerance remains unclear. In this study, we examined the role of the B7 family members of costimulatory molecules in the establishment of oral tolerance.
Fukaya, Tomohiro, Takagi, Hideaki, Sato, Yumiko, Sato, Kaori, Eizumi, Kawori, Taya, Honami, Shin, Tahiro, Chen, Lieping, Dong, Chen, Azuma, Miyuki, Yagita, Hideo, Malissen, Bernard, Sato, Katsuaki   +12 more
openaire   +3 more sources

Recurrent glioma clinical trial, CheckMate-143: the game is not over yet [PDF]

, 2017
Glioblastoma (GBM) is the most common, and aggressive, primary brain tumor in adults. With a median patient survival of less than two years, GBM represents one of the biggest therapeutic challenges of the modern era.
Dey, Mahua, Filley, Anna C., Henriquez, Mario   +2 more
core   +2 more sources

CHARACTERISTICS OF SIGNALING PATHWAYS MEDIATING A CYTOTOXIC EFFECT OF DENDRITIC CELLS UPON ACTIVATED Т LYMPHOCYTES AND NK CELLS

Медицинская иммунология, 2014
. Cytotoxic/pro-apoptogenic effects of IFNα-induced dendritic cells (IFN-DCs) directed against Т-lymphocytes and NK cells were investigated in healthy donors.
T. V. Tyrinova, O. Yu. Leplina, M. A. Tikhonova, L. V. Sakhno, A. A. Ostanin, E. R. Chernykh   +5 more
doaj   +1 more source

Development of a Novel Extracellular Vesicle‐Based Biomarker Approach for Pediatric High‐Grade Glioma [PDF]

J Extracell Biol
ABSTRACT Pediatric high‐grade gliomas (pHGGs) account for 20% of childhood brain tumours and are associated with poor survival. Currently, pHGG detection relies on MRI, a costly and time‐consuming procedure. Extracellular vesicles (EVs) carry molecular markers indicative of their cellular origin and can be isolated from various biofluids, offering an ...
Fernandez Garcia A, Iyer P, Ashi P, Tella I, Sangaraboina V, Bhagat D, Janarthanam C, Bargues‐Carot A, Kanthasamy A, Spoerer T, Golan M, Stice S, Funato K.   +12 more
europepmc   +2 more sources

Synergistic effects of IL-4 and TNFα on the induction of B7-H1 in renal cell carcinoma cells inhibiting allogeneic T cell proliferation [PDF]

, 2014
BACKGROUND: The importance of B7-H molecules for the T cell/tumor communication and its impact on renal cell carcinoma (RCC) progression and prognosis has been recently described.
Barbara Seliger, Bianca Schulze, Dagmar Quandt, Simon Jasinski-Bergner, Ulrike Müller   +4 more
core   +2 more sources

Hantavirus-driven PD-L1/PD-L2 upregulation: An imperfect viral immune evasion mechanism [PDF]

, 2018
Viruses often subvert antiviral immune responses by taking advantage of inhibitory immune signaling. We investigated if hantaviruses use this strategy.
Abdelaziz, Mohammed O., Hofmann, Jörg, Raftery, Martin J., Schönrich, Günther   +3 more
core   +2 more sources

Specific zinc finger‐induced methylation of PD‐L1 promoter inhibits its expression

FEBS Open Bio, 2019
DNA methylation of promoter regions is often associated with epigenetic silencing of gene expression, and DNA methyltransferase (DNMTs) has been used to suppress gene expression.
Xue Li, Zhenni Wang, Jiansheng Huang, Huazao Luo, Sibo Zhu, Han Yi, Liuhai Zheng, Bo Hu, Lili Yu, Lingzhi Li, Jun Xie, Naishuo Zhu   +11 more
doaj   +1 more source

CpGs Induce Differentiation of Atlantic Salmon Mononuclear Phagocytes Into Cells With Dendritic Morphology and a Proinflammatory Transcriptional Profile but an Exhausted Allostimulatory Activity

Frontiers in Immunology, 2019
Due to their ability to present foreign antigens and prime naïve T cells, macrophages, and dendritic cells (DCs) are referred to as professional antigen-presenting cells (APCs).
Dimitar B. Iliev, Dimitar B. Iliev, Leidy Lagos, Hanna L. Thim, Sven M. Jørgensen, Aleksei Krasnov, Jorunn B. Jørgensen   +6 more
doaj   +1 more source

The PD-1/PD-L1 Axis and Virus Infections: A Delicate Balance [PDF]

, 2019
Programmed cell death protein (PD-1) and its ligands play a fundamental role in the evasion of tumor cells from antitumor immunity. Less well appreciated is the fact that the PD-1/PD-L1 axis also regulates antiviral immune responses and is therefore ...
Raftery, Martin J., Schönrich, Günther
core   +1 more source