Results 71 to 80 of about 21,980 (135)

MARCO+ Tumor‐Associated Macrophages Impede CD8+ T Cell Immunity to Facilitate Immunotherapy Resistance in Renal Cell Carcinoma

Advanced Science, Volume 12, Issue 47, December 18, 2025.
MARCO+ TAMs dominate restrained cytotoxicity of CD8+ CTLs and ICB resistance in RCC. Mechanically, MARCO impairs MHC‐I‐mediated neoantigen cross‐presentation via the SOCS1‐JAK1‐STAT1‐NLRC5 signaling cascade in TAMs. Targeted MARCO treatment boosts macrophage antigen cross‐presentation and empowers CD8+ T cells, thereby potentiating ICB efficacy ...
Jiayuan Chen, Jiazhi Mo, Jinchang Wei, Mengnan Qu, Jie Dai, Yan Kong, Huayan Xu, Juan Li, Xieqiao Yan, Chuanliang Cui, Lu Si, Zhihong Chi, Jun Guo, Xiaowen Wu, Xinan Sheng   +14 more
wiley   +1 more source

The Role of the PD-1 Immunoreceptor in Pregnancy [PDF]

, 2008
During pregnancy, the maternal immune system must be carefully modulated as the fetus is immunologically foreign to her leukocytes. We propose that the CD28 family immune receptor, PD-1, functions during pregnancy to control maternal immune reactions. PD-
Taglauer, Elizabeth Susan
core  

lHuman cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis [PDF]

, 2005
Effector-memory T cells expressing Fas (Apo-1/CD95) are switched to an apoptotic program by cross-linking with Fas-ligand (FasL). Consequently, tumors that express FasL can induce apoptosis of infiltrating Fas-positive T lymphocytes and subdue any ...
Biagi, E, Brenner, MK, Dotti, G, Pule, M, Rooney, CM, Savoldo, B, Straathof, KC, Vigouroux, S, Yvon, E   +8 more
core  

Checkpoint inhibitors: What gastroenterologists need to know. [PDF]

, 2018
Checkpoint inhibitors are increasingly being used in clinical practice. They can cause various gastrointestinal, hepatic and pancreatic side effects. As these side effects can be serious, appropriate management is essential.
Ahmed, Monjur
core   +1 more source

Einfluss von Herztransplantation und Stammzelltransplantation auf den Interleukin-2 Spiegel im Mausmodell [PDF]

, 2011
Die Transplantation solider Organe hat einen festen Platz in der heutigen Medizin. Trotz der bereits erstaunlichen Ergebnisse nach Organtransplantationen bleibt der Wermutstropfen der lebenslangen, nebenwirkungsreichen immunsuppressiven Therapie.
Knuth, Juergen
core  

The presence of programmed death 1 (PD-1)-positive tumor-infiltrating lymphocytes is associated with poor prognosis in human breast cancer [PDF]

, 2018
Programmed death 1 (PD-1) is a co-inhibitory receptor in the CD28/CTL-4 family, and functions as a negative regulator of the immune system. Tumor-infiltrating lymphocytes (TIL) in many epithelial cancers express PD-1, suggesting that antitumor immunity ...
Gao, F., Gillanders, W., Muenst, S., Obermann, E., Oertli, D., Soysal, S.   +5 more
core  

Therapeutic Vaccination against Cancers - A Conceptual Overview with Updates on the Immunological Approach [PDF]

, 2015
Cancer immunotherapy has now finally made its way and entered a new era, after decades of intensive searching of a cure for the incurable. Current attentions are particularly drawn by the very promising outcomes from a series of experimental and clinical
Huang, FP
core  

Poster Session 3

Pregnancy, Volume 2, Issue S1, January 2026.
wiley   +1 more source

Single mutation tunes IRF4 function and mediates B cell character to ameliorate murine lupus. [PDF]

iScience
Xiao ZX, Liang R, Hu X, Huang C, Nie J, Xie C, Wang J, Fang Q, Fan X, Olsen N, Zhou L, Li B, Zheng SG.   +12 more
europepmc   +1 more source

Development and characterization of a novel B7-H3 rabbit monoclonal antibody for glioma diagnosis. [PDF]

Front Pharmacol
Li Y, Wang Z, Wen Q, Chiu M, Jia X, Li Y, Shang X.   +6 more
europepmc   +1 more source