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Annual Review of Cell and Developmental Biology, 2020 Innate and adaptive immune responses decline with age, leading to greater susceptibility to infectious diseases and reduced responses to vaccines. Diseases are more severe in old than in young individuals and have a greater impact on health outcomes such as morbidity, disability, and mortality.
Bonnie B. Blomberg +4 more
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Antibody Response following Exposure to SARS-CoV-2: Is It a Reliable Marker of Immunity? [PDF]
Journal of Clinical and Diagnostic Research, 2022 Introduction: Infection and vaccination with the viral vector vaccine Covishield are both expected to produce immunity in the body against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2).
Mona Dhakal +2 more
doaj +1 more source
Science immunology, 2021 Novel mRNA vaccines for SARS-CoV-2 have been authorized for emergency use. Despite their efficacy in clinical trials, data on mRNA vaccine-induced immune responses are mostly limited to serological analyses.
R. Goel +30 more
semanticscholar +1 more source
Diffuse Large B-Cell Lymphoma.
New England Journal of Medicine, 2021 Large B-cell lymphomas, with an estimated 150,000 new cases annually worldwide, represent almost 30% of all cases of non-Hodgkin’s lymphoma. Patients typically present with progressive lymphadenopathy, extranodal disease, or both and require therapy ...
L. Sehn, G. Salles
semanticscholar +1 more source
B cells and cancer: To B or not to B?
Journal of Experimental Medicine, 2020 Whereas T cells have been considered the major immune cells of the tumor microenvironment able to induce tumor regression and control cancer clinical outcome, a burst of recent publications pointed to the fact that B cells may also play a prominent role.
Wolf Herman Fridman +6 more
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Inhibition of T cell/B cell interaction by B-CLL cells [PDF]
Leukemia, 1999 The course of disease in patients suffering from chronic lymphocytic leukemia (CLL) is determined by a profound dysregulation of the immune system. The resulting immune suppression is the main cause of death in those patients. In the present study we addressed the question of whether leukemic B cells (B-CLL) are able to suppress regular T cell/B cell ...
Mehringer C +6 more
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Gynecology and Minimally Invasive Therapy, 2020 Ovarian diffuse large B-cell lymphoma (DLBCL) is rare. DLBCL is a complex type of lymphoma. The ovarian DLBCL usually harbor a favorable prognosis. We report a case of ovarian DLBCL that presented as an ovarian mass with lower abdominal pain and was ...
Pei- Chen Li +3 more
doaj +1 more source
Human IgM+CD27+ B Cells: Memory B Cells or “Memory” B Cells? [PDF]
The Journal of Immunology, 2007 Abstract Memory B cells are generated in germinal centers (GC) and contribute to serological immunity by rapidly differentiating into plasma cells. Human memory B cells can be identified by the expression of CD27. These cells exhibit more rapid responses than naive (CD27−) B cells following stimulation in vitro, consistent with the ...
Stuart G. Tangye, Kim L. Good
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B cell targeted therapy for immunoglobulin G4-related disease
Immunological Medicine, 2021 Glucocorticoids are the first-line drug for the remission induction therapy of immunoglobulin (Ig) G4-related disease. Achieving drug-free remission using glucocorticoids alone is difficult, however, and many patients require maintenance therapy with ...
Motohisa Yamamoto
doaj +1 more source
An isolated burkitt's iymphoma of the chest wall: First case reported in a malagasy child [PDF]
Journal of Cardio-Thoracic Medicine, 2020 Primary Burkitt lymphomas of the chest wall are relatively rare in occurrence. The authors describe a first case report in Malagasy child. It presents as an isolated soft-tissue mass on the chest wall with a sudden installation of paraplegia in an 8-year-
Narindra Njarasoa Mihaja Razafimanjato +4 more
doaj +1 more source