Results 1 to 10 of about 151,659 (99)
B cells and cancer: To B or not to B?
Journal of Experimental Medicine, 2020 Whereas T cells have been considered the major immune cells of the tumor microenvironment able to induce tumor regression and control cancer clinical outcome, a burst of recent publications pointed to the fact that B cells may also play a prominent role.
Wolf Herman Fridman +6 more
openaire +5 more sources
Inhibition of T cell/B cell interaction by B-CLL cells [PDF]
Leukemia, 1999 The course of disease in patients suffering from chronic lymphocytic leukemia (CLL) is determined by a profound dysregulation of the immune system. The resulting immune suppression is the main cause of death in those patients. In the present study we addressed the question of whether leukemic B cells (B-CLL) are able to suppress regular T cell/B cell ...
Mehringer C +6 more
openaire +2 more sources
Human IgM+CD27+ B Cells: Memory B Cells or “Memory” B Cells? [PDF]
The Journal of Immunology, 2007 Abstract Memory B cells are generated in germinal centers (GC) and contribute to serological immunity by rapidly differentiating into plasma cells. Human memory B cells can be identified by the expression of CD27. These cells exhibit more rapid responses than naive (CD27−) B cells following stimulation in vitro, consistent with the ...
Stuart G. Tangye, Kim L. Good
openaire +3 more sources
Whatever will B cell be? [PDF]
Nature Reviews Immunology, 2015 Individual naive B cells show heterogeneity in their response to antigen-mediated activation.
openaire +2 more sources
Stromal Cells Attract B‐Cell Progenitors to Promote B‐Cell–B‐Cell Contact and Maturation [PDF]
Scandinavian Journal of Immunology, 2005 AbstractThe in vitro differentiation of B‐lineage progenitors into Ig‐secreting mature B cells has classically required a co‐culture system containing lipopolysaccharide (LPS) and stromal cells. We have previously showed that B‐lineage progenitors cultured in round‐bottomed wells can mature and secrete immunoglobulin M (IgM) on par with cultures ...
Craig D. Milne +2 more
openaire +3 more sources
Experimental Cell Research, 2017 The ability of cells to sense and adapt to changes in oxygen is mediated by hypoxia-inducible factor (HIF). Immune cells function in physiologically complex and varying environments whereby oxygen, pH, nutrients, metabolites and cytokines are continuously fluctuating.
Burrows, N, Maxwell, PH
openaire +4 more sources
Arthritis Research & Therapy, 2009 B-cell development is tightly regulated, including the induction of B-cell memory and antibody-secreting plasmablasts and plasma cells. In the last decade, we have expanded our understanding of effector functions of B cells as well as their roles in human autoimmune diseases. The current review addresses the role of certain stages of B-cell development
Thomas Dörner +2 more
openaire +3 more sources
Unique B cell responses in B cell-dependent and B cell-independent EAE
Autoimmunity, 2011 Previous studies characterized B cell-dependent and B cell-independent models of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice. To further characterize the B cell response generated in these two models, the serum antibody response and the B cell surface immunoglobulin (Ig) repertoire were analyzed following immunization of wild-type ...
Kamaldeen A. Muili +3 more
openaire +2 more sources
T cell–B cell collaboration [PDF]
Nature Reviews Immunology, 2017 Jonathan Sprent describes a 1968 study by Graham Mitchell and Jacques Miller that showed the requirement for T cell–B cell collaboration for antibody production.
openaire +3 more sources
T-cells and B-cells in osteoporosis [PDF]
Current Opinion in Endocrinology, Diabetes & Obesity, 2014 Bone disease is a leading cause of fractures and continues to be a source of significant morbidity and mortality worldwide. As the underlying mechanisms of osteoporosis are elucidated, immune dysfunction continues to emerge as a key precipitating factor in multiple bone disease contexts. This review examines recent findings in the osteoimmunology field
openaire +3 more sources