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Annual Review of Cell and Developmental Biology, 2020 Innate and adaptive immune responses decline with age, leading to greater susceptibility to infectious diseases and reduced responses to vaccines. Diseases are more severe in old than in young individuals and have a greater impact on health outcomes such as morbidity, disability, and mortality.
Bonnie B. Blomberg +4 more
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Antibody Response following Exposure to SARS-CoV-2: Is It a Reliable Marker of Immunity? [PDF]
Journal of Clinical and Diagnostic Research, 2022 Introduction: Infection and vaccination with the viral vector vaccine Covishield are both expected to produce immunity in the body against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2).
Mona Dhakal +2 more
doaj +1 more source
Axicabtagene Ciloleucel as Second-Line Therapy for Large B-Cell Lymphoma.
New England Journal of Medicine, 2021 BACKGROUND The prognosis of patients with early relapsed or refractory large B-cell lymphoma after the receipt of first-line chemoimmunotherapy is poor.
F. Locke +30 more
semanticscholar +1 more source
Gynecology and Minimally Invasive Therapy, 2020 Ovarian diffuse large B-cell lymphoma (DLBCL) is rare. DLBCL is a complex type of lymphoma. The ovarian DLBCL usually harbor a favorable prognosis. We report a case of ovarian DLBCL that presented as an ovarian mass with lower abdominal pain and was ...
Pei- Chen Li +3 more
doaj +1 more source
Science immunology, 2021 Novel mRNA vaccines for SARS-CoV-2 have been authorized for emergency use. Despite their efficacy in clinical trials, data on mRNA vaccine-induced immune responses are mostly limited to serological analyses.
R. Goel +30 more
semanticscholar +1 more source
B cells and cancer: To B or not to B?
Journal of Experimental Medicine, 2020 Whereas T cells have been considered the major immune cells of the tumor microenvironment able to induce tumor regression and control cancer clinical outcome, a burst of recent publications pointed to the fact that B cells may also play a prominent role.
Wolf Herman Fridman +6 more
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Inhibition of T cell/B cell interaction by B-CLL cells [PDF]
Leukemia, 1999 The course of disease in patients suffering from chronic lymphocytic leukemia (CLL) is determined by a profound dysregulation of the immune system. The resulting immune suppression is the main cause of death in those patients. In the present study we addressed the question of whether leukemic B cells (B-CLL) are able to suppress regular T cell/B cell ...
Mehringer C +6 more
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B Cell Function in the Tumor Microenvironment.
Annual Review of Immunology, 2022 The tumor microenvironment (TME) is a heterogeneous, complex organization composed of tumor, stroma, and endothelial cells that is characterized by cross talk between tumor and innate and adaptive immune cells.
Stephanie M Downs-Canner +3 more
semanticscholar +1 more source
B cell targeted therapy for immunoglobulin G4-related disease
Immunological Medicine, 2021 Glucocorticoids are the first-line drug for the remission induction therapy of immunoglobulin (Ig) G4-related disease. Achieving drug-free remission using glucocorticoids alone is difficult, however, and many patients require maintenance therapy with ...
Motohisa Yamamoto
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Human IgM+CD27+ B Cells: Memory B Cells or “Memory” B Cells? [PDF]
The Journal of Immunology, 2007 Abstract Memory B cells are generated in germinal centers (GC) and contribute to serological immunity by rapidly differentiating into plasma cells. Human memory B cells can be identified by the expression of CD27. These cells exhibit more rapid responses than naive (CD27−) B cells following stimulation in vitro, consistent with the ...
Stuart G. Tangye, Kim L. Good
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